Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

Novartis trial validates inflammasome as chronic disease driver

(2017) Cormac Sheridan   NATURE BIOTECHNOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Borinic acid catalysed peptide synthesis

(2015) Tharwat Mohy El Dine et al.   CHEMICAL COMMUNICATIONS

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

(2015) Ji-chun Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Inhibiting the Inflammasome: A Chemical Perspective

(2015) Alex G. Baldwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

(2013) Susannah D. Brydges et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Sterile inflammatory responses mediated by the NLRP3 inflammasome

(2010) Suzanne L. Cassel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Therapeutic potential of boron-containing compounds

(2009) Stephen J Baker et al.   Future Medicinal Chemistry

Kinetics of Bromine−Magnesium Exchange Reactions in Substituted Bromobenzenes

(2009) Lei Shi et al.   JOURNAL OF ORGANIC CHEMISTRY

Relative Rates of Bromine–Magnesium Exchange Reactions in Substituted Bromobenzene Derivatives

(2007) Lei Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION