Mitochondrial Ca2+ in heart failure: Not enough or too much?

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve

(2019) Tariq R. Altamimi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs

(2019) Dawud Abawi et al.   BMC Cardiovascular Disorders

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart FailureNovelty and Significance

(2018) Swati Dey et al.   CIRCULATION RESEARCH

Mitochondrial Ca 2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy

(2018) An Xie et al.   Journal of the American Heart Association

Cyclophilin D-mediated regulation of the permeability transition pore is altered in mice lacking the mitochondrial calcium uniporter

(2018) Randi J Parks et al.   CARDIOVASCULAR RESEARCH

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

(2018) Melanie Paillard et al.   MOLECULAR CELL

Reactive Oxygen Species from NADPH Oxidase and Mitochondria Participate in the Proliferation of Aortic Smooth Muscle Cells from a Model of Metabolic Syndrome

(2018) Ocarol López-Acosta et al.   Oxidative Medicine and Cellular Longevity

Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

(2018) Shanna Hamilton et al.   Frontiers in Physiology

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

MICU2 Restricts Spatial Crosstalk between InsP 3 R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

(2017) Riley Payne et al.   Cell Reports

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes

(2016) Swati Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death

(2016) D. Brian Foster et al.   JOURNAL OF PROTEOME RESEARCH

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

(2015) Aleksandr E. Vendrov et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca 2+ Wave Generation

(2015) Elisa Bovo et al.   BIOPHYSICAL JOURNAL

CCDC90A (MCUR1) Is a Cytochrome c Oxidase Assembly Factor and Not a Regulator of the Mitochondrial Calcium Uniporter

(2015) Vincent Paupe et al.   Cell Metabolism

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

(2015) Alexander G. Nickel et al.   Cell Metabolism

Dual Effect of Phosphate Transport on Mitochondrial Ca2+Dynamics

(2015) An-Chi Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

(2015) Kira M. Holmström et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

(2015) Tyler P. Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial uniporter controls fight or flight heart rate increases

(2015) Yuejin Wu et al.   Nature Communications

Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca2+

(2015) Markus Waldeck-Weiermair et al.   Scientific Reports

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

(2014) Ting Liu et al.   CIRCULATION RESEARCH

High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII

(2014) Swati S. Jain et al.   DIABETES

Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts

(2013) Nina Kaludercic et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel aspects of ROS signalling in heart failure

(2013) Anne D. Hafstad et al.   BASIC RESEARCH IN CARDIOLOGY

Calcium release microdomains and mitochondria

(2013) Michael Kohlhaas et al.   CARDIOVASCULAR RESEARCH

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death

(2013) Ali A. Sovari et al.   Circulation-Arrhythmia and Electrophysiology

Na+ transport in the normal and failing heart — Remember the balance

(2013) Sanda Despa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+handling in ageing rabbit hearts

(2013) Leroy L. Cooper et al.   JOURNAL OF PHYSIOLOGY-LONDON

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

Dynamics of matrix-free Ca2+in cardiac mitochondria: two components of Ca2+uptake and role of phosphate buffering

(2012) An-Chi Wei et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress

(2011) Dao-Fu Dai et al.   CARDIOVASCULAR RESEARCH

Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress

(2011) Lufang Zhou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Redox-optimized ROS balance: A unifying hypothesis

(2010) M.A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

(2010) Gad A. Silberman et al.   CIRCULATION

Elevated Cytosolic Na + Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

(2010) Michael Kohlhaas et al.   CIRCULATION

Role of mitochondrial dysfunction in cardiac glycoside toxicity

(2010) Ting Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential sensitivity of Ca2+wave and Ca2+spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes

(2010) N. MacQuaide et al.   JOURNAL OF PHYSIOLOGY-LONDON

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Regulation of the Human Cardiac Mitochondrial Ca 2+ Uptake by 2 Different Voltage-Gated Ca 2+ Channels

(2009) Guido Michels et al.   CIRCULATION

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca 2+ Leak in Chronic Heart Failure

(2008) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

(2008) Ting Liu et al.   CIRCULATION RESEARCH