The antidepressant-like effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB signaling pathway and neurogenesis in the hippocampus

Research progress on classical traditional Chinese medicine formula Lily Bulb and Rehmannia Decoction in the treatment of depression

(2019) Xiansu Chi et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways

(2019) Xie et al.   Biomolecules

Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus

(2019) Ning Jiang et al.   BRAIN RESEARCH BULLETIN

Mechanisms of Panax ginseng action as an antidepressant

(2019) Yang Jin et al.   CELL PROLIFERATION

Ginsenoside Rg3 promotes Fc gamma receptor-mediated phagocytosis of bacteria by macrophages via an extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent mechanism

(2019) Chun Xin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats

(2018) Xinyang Qi et al.   ACS Chemical Neuroscience

The antidepressant-like effects of Chaihu Shugan San: Dependent on the hippocampal BDNF-TrkB-ERK/Akt signaling activation in perimenopausal depression-like rats

(2018) Xue-Qin Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

The protective effect of 20( S )-protopanaxadiol (PPD) against chronic sleep deprivation (CSD)-induced memory impairments in mice

(2018) Cong Lu et al.   BRAIN RESEARCH BULLETIN

Proteomic Analysis of the Antidepressant Effects of Shen–Zhi–Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism

(2018) Chao Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress-induced depressive mice

(2018) Ning Jiang et al.   PHYTOTHERAPY RESEARCH

DOES PHYSICAL EXERCISE INCREASE BRAIN-DERIVED NEUROTROPHIC FACTOR IN MAJOR DEPRESSIVE DISORDER? A META-ANALYSIS

(2018) Yusuke Kurebayashi et al.   Psychiatria Danubina

Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression

(2018) Yu Ri Kim et al.   Biomed Research International

Radix Scutellariae Attenuates CUMS-Induced Depressive-Like Behavior by Promoting Neurogenesis via cAMP/PKA Pathway

(2018) Ruyi Zhang et al.   NEUROCHEMICAL RESEARCH

Depression

(2018) Gin S Malhi et al.   LANCET

Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors

(2018) Chang-An Geng et al.   JOURNAL OF ETHNOPHARMACOLOGY

The effects of sEH inhibitor on depression-like behavior and neurogenesis in male mice

(2017) Qiong Wu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex

(2016) Song liu et al.   BEHAVIOURAL BRAIN RESEARCH

Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

(2016) Naoko Abe-Higuchi et al.   BIOLOGICAL PSYCHIATRY

Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron

(2016) Yue Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidepressant-like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina Baroni in chronic unpredictable mild stress rats and its related mechanism

(2016) Pan Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation

(2016) Zhe Shi et al.   MOLECULAR NEUROBIOLOGY

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

(2016) Z. Liu et al.   NEUROSCIENCE

The Effects of Calorie Restriction in Depression and Potential Mechanisms

(2015) Yifan Zhang et al.   Current Neuropharmacology

Macranthol promotes hippocampal neuronal proliferation in mice via BDNF–TrkB–PI3K/Akt signaling pathway

(2015) Liu Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The antidepressant-like pharmacological profile of Yuanzhi-1, a novel serotonin, norepinephrine and dopamine reuptake inhibitor

(2015) Zeng-liang Jin et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway

(2015) Bo Jiang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13

(2015) Yang Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway

(2015) Francis L. Pazini et al.   MOLECULAR NEUROBIOLOGY

Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice

(2015) W. Wang et al.   NEUROSCIENCE

Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25–35 peptides in vitro and in vivo

(2015) Ya-min Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression

(2015) Wen-Xue Liu et al.   PSYCHOPHARMACOLOGY

Fluoxetine: a case history of its discovery and preclinical development

(2014) Laura Perez-Caballero et al.   Expert Opinion on Drug Discovery

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats

(2014) Amine Bahi et al.   PSYCHONEUROENDOCRINOLOGY

Antidepressant-like effects and memory enhancement of a herbal formula in mice exposed to chronic mild stress

(2013) Xiu-Ping Sun et al.   Neuroscience Bulletin

Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

(2012) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running

(2011) Yin Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose fromPolygala tenuifoliaWilld

(2011) Yuan Hu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus

(2011) Yosuke Yamawaki et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Monoaminergic Neurotransmission: The History of the Discovery of Antidepressants from 1950s Until Today

(2009) Francisco Lopez-Munoz et al.   CURRENT PHARMACEUTICAL DESIGN

Brain‐derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood‐derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt‐dependent signaling pathways

(2008) Jung Yeon Lim et al.   JOURNAL OF NEUROSCIENCE RESEARCH