Rational design of adjuvants for subunit vaccines: The format of cationic adjuvants affects the induction of antigen-specific antibody responses

Immunological and Toxicological Considerations for the Design of Liposomes

(2020) Collin T. Inglut et al.   Nanomaterials

Translating the fabrication of protein-loaded poly(lactic-co-glycolic acid) nanoparticles from bench to scale-independent production using microfluidics

(2020) Carla B. Roces et al.   Drug Delivery and Translational Research

Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants

(2020) Yunys Pérez-Betancourt et al.   Vaccines

Design of a novel vaccine nanotechnology-based delivery system comprising CpGODN-protein conjugate anchored to liposomes

(2020) Despo Chatzikleanthous et al.   JOURNAL OF CONTROLLED RELEASE

Cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses

(2019) Adelijiang Wusiman et al.   International Journal of Nanomedicine

Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration

(2019) Signe Tandrup Schmidt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization

(2019) Ning Wang et al.   JOURNAL OF CONTROLLED RELEASE

The Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology

(2019) Vega Masignani et al.   Frontiers in Immunology

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies

(2019) Carla B. Roces et al.   MOLECULAR PHARMACEUTICS

A novel microfluidic-based approach to formulate size-tuneable large unilamellar cationic liposomes: Formulation, cellular uptake and biodistribution investigations

(2019) Gustavo Lou et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Comparative pharmacokinetic and biodistribution study of two distinct squalene-containing oil-in-water emulsion adjuvants in H5N1 influenza vaccines

(2019) Million A. Tegenge et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Effects of core size and PEG coating layer of iron oxide nanoparticles on the distribution and metabolism in mice

(2018) Weiming Xue et al.   International Journal of Nanomedicine

Influence of PEG coating on the biodistribution and tumor accumulation of pH-sensitive liposomes

(2018) Shirleide Santos Nunes et al.   Drug Delivery and Translational Research

AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization

(2018) Surender Khurana et al.   npj Vaccines

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

(2018) Parisa Foroozandeh et al.   Nanoscale Research Letters

NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies

(2018) Alessia Liguori et al.   mBio

Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines

(2017) Luis O. De Serrano et al.   JOURNAL OF NANOBIOTECHNOLOGY

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Solid lipid nanoparticles for encapsulation of hydrophilic drugs by an organic solvent free double emulsion technique

(2016) Luana Becker Peres et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

(2016) Arnaud M. Didierlaurent et al.   Expert Review of Vaccines

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

(2016) Signe Tandrup Schmidt et al.   Pharmaceutics

Vaccine Adjuvant MF59 Promotes Retention of Unprocessed Antigen in Lymph Node Macrophage Compartments and Follicular Dendritic Cells

(2015) Rocco Cantisani et al.   JOURNAL OF IMMUNOLOGY

Optimizing cationic and neutral lipids for efficient gene delivery at high serum content

(2014) Chia-Ling Chan et al.   JOURNAL OF GENE MEDICINE

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

(2014) W. M. Bogers et al.   JOURNAL OF INFECTIOUS DISEASES

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody

(2014) Enrico Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(lactic-co-glycolic) Acid-Controlled-Release Systems: Experimental and Modeling Insights

(2013) Daniel J. Hines et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants

(2013) Mohammed Jubair Hussain et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

(2013) M. Vono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emulsion based vaccine adjuvants

(2013) Derek T O'Hagan et al.   Human Vaccines & Immunotherapeutics

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

(2012) Dennis Christensen et al.   JOURNAL OF CONTROLLED RELEASE

Synchronization of Dendritic Cell Activation and Antigen Exposure Is Required for the Induction of Th1/Th17 Responses

(2012) A. T. Kamath et al.   JOURNAL OF IMMUNOLOGY

Effect of the Poly(ethylene glycol) (PEG) Density on the Access and Uptake of Particles by Antigen-Presenting Cells (APCs) after Subcutaneous Administration

(2012) Xi Zhan et al.   MOLECULAR PHARMACEUTICS

Protein Antigen Adsorption to the DDA/TDB Liposomal Adjuvant: Effect on Protein Structure, Stability, and Liposome Physicochemical Characteristics

(2012) Mette Hamborg et al.   PHARMACEUTICAL RESEARCH

Small Cationic DDA:TDB Liposomes as Protein Vaccine Adjuvants Obviate the Need for TLR Agonists in Inducing Cellular and Humoral Responses

(2012) Anita Milicic et al.   PLoS One

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Cationic liposomes as vaccine adjuvants

(2011) Dennis Christensen et al.   Expert Review of Vaccines

The long-term potential of biodegradable poly(lactideco-glycolide) microparticles as the next-generation vaccine adjuvant

(2011) Siddhartha Jain et al.   Expert Review of Vaccines

The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production

(2011) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated cationic liposomes robustly augment vaccine-induced immune responses: Role of lymphatic trafficking and biodistribution

(2011) Yan Zhuang et al.   JOURNAL OF CONTROLLED RELEASE

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo

(2010) Pernille Nordly et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists

(2010) Matthew Black et al.   Expert Review of Vaccines

Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect

(2010) Jana Pardeike et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

(2010) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses

(2010) Malou Henriksen-Lacey et al.   MOLECULAR PHARMACEUTICS

Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies

(2010) Malou Henriksen-Lacey et al.   Pharmaceutics

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

(2009) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

How to achieve sustained and complete protein release from PLGA-based microparticles?

(2007) A. Giteau et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS