Multiple functions of p21 in cancer radiotherapy

BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest

(2020) Zhi-min Zeng et al.   LIFE SCIENCES

Building radiation-resistant model in triple-negative breast cancer to screen radioresistance-related molecular markers

(2020) Zhi-Rui Zhou et al.   Annals of Translational Medicine

Modulating the dose-rate differently affects the responsiveness of human epithelial prostate- and mesenchymal rhabdomyosarcoma-cancer cell line to radiation

(2020) Francesco Petragnano et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Astragaloside IV ameliorates radiation‐induced senescence via antioxidative mechanism

(2020) Xin Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

LncRNA TTN‐AS1/miR‐134‐5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK‐3β/β‐catenin pathway

(2020) Zhenkui Zuo et al.   CELL BIOLOGY INTERNATIONAL

Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21

(2020) Cheng Wu et al.   Molecular Therapy-Oncolytics

125I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts

(2020) Qing Jin et al.   Radiation Oncology

Effects of miR-373 Inhibition on Glioblastoma Growth by Reducing Limk1 In Vitro

(2020) Tao Peng et al.   Journal of Immunology Research

CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics

(2019) Debarati Ghosh et al.   Cancer Cell International

Radiotherapy toxicity

(2019) Dirk De Ruysscher et al.   Nature Reviews Disease Primers

Auranofin protects intestine against radiation injury by modulating p53/p21 pathway and radio-sensitizes human colon tumor

(2019) Dhrubajyoti Nag et al.   CLINICAL CANCER RESEARCH

Fetal origin confers radio-resistance on liver macrophages via p21cip1/WAF1

(2019) Radika Soysa et al.   JOURNAL OF HEPATOLOGY

P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy

(2019) D.M. Fernández-Aroca et al.   CANCER LETTERS

The RNA-binding protein RBM47 is a novel regulator of cell fate decisions by transcriptionally controlling the p53-p21-axis

(2019) Claudia Radine et al.   CELL DEATH AND DIFFERENTIATION

Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity

(2019) Vinod Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy

(2019) Kreis et al.   Cancers

p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress

(2019) Kanjoormana Manu et al.   Cancers

Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest

(2019) Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human CCR6+ Th17 Lymphocytes Are Highly Sensitive to Radiation-Induced Senescence and Are a Potential Target for Prevention of Radiation-Induced Toxicity

(2019) Hoang Quy Nguyen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

(2019) Clément Crochemore et al.   Nature Communications

Combination of IFITM1 knockdown and radiotherapy inhibits the growth of oral cancer

(2018) Jie Yang et al.   CANCER SCIENCE

Ionizing radiation-induced cellular senescence promotes tissue fibrosis after radiotherapy. A review

(2018) Hoang Quy Nguyen et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Transcriptional Landscape of Radiation-Treated Human Prostate Cancer: Analysis of a Prospective Tissue Cohort

(2018) Simon P. Keam et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radioprotective effect of melatonin on expression of Cdkn1a and Rad50 genes in rat peripheral blood

(2018) Pantea Izadi et al.   Journal of Cancer Research and Therapeutics

Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes

(2018) Ann E. Collier et al.   MOLECULAR BIOLOGY OF THE CELL

MicroRNA-125 modulates radioresistance through targeting p21 in cervical cancer

(2018) Abraham Pedroza‑Torres et al.   ONCOLOGY REPORTS

Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis

(2018) Xianghe Liu et al.   OncoTargets and Therapy

OUP accepted manuscript

(2018)   JOURNAL OF RADIATION RESEARCH

The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

(2018) Maja Milanovic et al.   TRENDS IN CELL BIOLOGY

RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation

(2018) Katarzyna Szołtysek et al.   BMC GENOMICS

The association of changes in RAD51 and survivin expression levels with the proton beam sensitivity of Capan‑1 and Panc‑1 human pancreatic cancer cells

(2018) Min‑Gu Lee et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance

(2017) Kuntal Biswas et al.   MOLECULAR CANCER RESEARCH

Long Noncoding RNA CRNDE/PRC2 Participated in the Radiotherapy Resistance of Human Lung Adenocarcinoma Through Targeting p21 Expression

(2017) Ming Zhang et al.   ONCOLOGY RESEARCH

Synergy between Auraptene, Ionizing Radiation, and Anticancer Drugs in Colon Adenocarcinoma Cells

(2017) Mahdi Moussavi et al.   PHYTOTHERAPY RESEARCH

Influence of autophagy on the efficacy of radiotherapy

(2017) Shing Yau Tam et al.   Radiation Oncology

p21: A Two-Faced Genome Guardian

(2017) Alexandros G. Georgakilas et al.   TRENDS IN MOLECULAR MEDICINE

Zoledronic acid augments the radiosensitivity of cancer cells through perturbing S- and M-phase cyclins and p21CIP1 expression

(2017) Chi Du et al.   Oncology Letters

TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth

(2016) Savvas C. Pavlides et al.   CELL CYCLE

Dual Role of p21 in the Progression of Cancer and Its Treatment

(2016) Amna Parveen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells

(2016) Yiting Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse

(2016) Michael McMahon et al.   MOLECULAR CANCER RESEARCH

Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

(2016) Thomas R. Gawriluk et al.   Nature Communications

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

(2015) Byeong Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer

(2015) Lin Zheng et al.   Journal of Translational Medicine

The Roles of p21Waf1/CIP1and Hus1 in Generation and Transmission of Damage Signals Stimulated by Low-Dose Alpha-Particle Irradiation

(2015) Ye Zhao et al.   RADIATION RESEARCH

Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype

(2015) Hee-Young Jeon et al.   TUMOR BIOLOGY

Infiltrating mast cells increase prostate cancer chemotherapy and radiotherapy resistances via modulation of p38/p53/p21 and ATM signals

(2015) Hongjun Xie et al.   Oncotarget

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer

(2015) Julia A. Yaglom et al.   Oncotarget

Less understood issues: p21Cip1 in mitosis and its therapeutic potential

(2014) N-N Kreis et al.   ONCOGENE

Oxidative Stress Associated with Neuronal Apoptosis in Experimental Models of Epilepsy

(2014) Marisela Méndez-Armenta et al.   Oxidative Medicine and Cellular Longevity

A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation

(2014) Lili Cao et al.   PLoS One

Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer

(2013) Ruiwu Liu et al.   Future Medicinal Chemistry

Aberrant promoter hypermethylation of p21 (WAF1/CIP1) gene and its impact on expression and role of polymorphism in the risk of breast cancer

(2013) Marjan Askari et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells

(2013) S.-Y. Wu et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts

(2013) Sergio Huerta et al.   SURGERY

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

(2012) Chandanamali Punchihewa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p21 promotes error-free replication-coupled DNA double-strand break repair

(2012) Maurizio Mauro et al.   NUCLEIC ACIDS RESEARCH

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

(2012) Dong Yang et al.   PLoS One

TGF-β-Activated Kinase 1 Promotes Cell Cycle Arrest and Cell Survival of X-Ray Irradiated HeLa Cells Dependent on p21 Induction but Independent of NF-κB, p38 MAPK and ERK Phosphorylations

(2012) Yukihiro Furusawa et al.   RADIATION RESEARCH

Radiation Sensitivity of Esophageal Adenocarcinoma: The Contribution of the RNA-Binding Protein RNPC1 and p21-Mediated Cell Cycle Arrest to Radioresistance

(2012) Gijsbert J. Hötte et al.   RADIATION RESEARCH

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

(2012) P. Elumalai et al.   TOXICOLOGY LETTERS

Therapeutic targeting of cancer cell cycle using proteasome inhibitors

(2012) Namrata Rastogi et al.   Cell Division

Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation

(2011) Manabu Koike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

(2011) Nicole Baptiste-Okoh et al.   CELL CYCLE

Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists

(2011) Hong Shen et al.   CURRENT PHARMACEUTICAL DESIGN

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

ATRcontrols the p21WAF1/Cip1protein up-regulation and apoptosis in response to low UV fluences

(2011) Huda H. Al-Khalaf et al.   MOLECULAR CARCINOGENESIS

FAK Deletion Promotes p53-Mediated Induction of p21, DNA-Damage Responses and Radio-Resistance in Advanced Squamous Cancer Cells

(2011) Kathryn Graham et al.   PLoS One

TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21WAF1/Cip1 and PTEN/AKT pathway

(2010) Eun Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers

(2010) See-Hyoung Park et al.   CANCER BIOLOGY & THERAPY

Examination of the expanding pathways for the regulation of p21 expression and activity

(2010) Yong-Sam Jung et al.   CELLULAR SIGNALLING

Restoring p53 tumor suppressor activity as an anticancer therapeutic strategy

(2010) Jesse D Martinez   Future Oncology

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

(2010) Roelof Koster et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Base Excision Repair as a Sensitization Strategy in Radiotherapy

(2010) Conchita Vens et al.   SEMINARS IN RADIATION ONCOLOGY

p21WAF1/CIP1and cancer: A shifting paradigm?

(2009) Andrei L. Gartel   BIOFACTORS

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis

(2009) Eun-Woo Lee et al.   EMBO JOURNAL

Spatiotemporal analysis of DNA repair using charged particle radiation

(2009) F. Tobias et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Involvement of Oct-1 in the regulation of CDKN1A in response to clinically relevant doses of ionizing radiation

(2008) Mitsuru Nenoi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Aberrant CDKN1A transcriptional response associates with abnormal sensitivity to radiation treatment

(2008) C Badie et al.   BRITISH JOURNAL OF CANCER

Senescence: the good the bad and the dysfunctional

(2008) Ermira Pazolli et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

(2008) G. Soria et al.   JOURNAL OF CELL SCIENCE

Antisense Attenuation of p21 Sensitizes Kidney Cancer to Apoptosis in Response to Conventional DNA Damaging Chemotherapy Associated With Enhancement of Phospho-p53

(2008) See-Hyoung Park et al.   JOURNAL OF UROLOGY

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

(2008) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

Ultraviolet light exposure triggers nuclear accumulation of p21WAF1and accelerated senescence in human normal and nucleotide excision repair-deficient fibroblast strains

(2007) Razmik Mirzayans et al.   JOURNAL OF CELLULAR PHYSIOLOGY