Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-Δ12,14-prostaglandin J2

Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice

(2017) Alessandra Bitto et al.   INFLAMMATION RESEARCH

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Prostaglandin I2upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice

(2016) Pu Wang et al.   AGING CELL

Prostaglandin I2 Attenuates Prostaglandin E2-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism

(2016) Pu Wang et al.   Scientific Reports

Magnesium ion influx reduces neuroinflammation in Aβ precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1β

(2015) Pu Wang et al.   Cellular & Molecular Immunology

By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

(2015) Xin Yu et al.   FASEB JOURNAL

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

(2013) Yoshiharu Akitake et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line

(2013) Christian W. Keller et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Positive and negative effects of prostaglandins in Alzheimer's disease

(2013) Mohammad Javad Fattahi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Inflammatory prostaglandin E2signaling in a mouse model of Alzheimer disease

(2012) Ju Shi et al.   ANNALS OF NEUROLOGY

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

(2012) Karim Belarbi et al.   Journal of Neuroinflammation

Improvement of cognitive function in Alzheimer’s disease model mice by genetic and pharmacological inhibition of the EP4 receptor

(2011) Tatsuya Hoshino et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Identification of Protein Targets for 15-Deoxy-Δ12,14-Prostaglandin J2 in Neuronal Plasma Membrane

(2011) Yasuhiro Yamamoto et al.   PLoS One

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease

(2010) M. Coma et al.   NEUROBIOLOGY OF DISEASE

Are NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment?

(2010) Imbimbo   Frontiers in Aging Neuroscience

Prostaglandin E2Stimulates the Production of Amyloid-β Peptides through Internalization of the EP4Receptor

(2009) Tatsuya Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

(2008) Ann C. McKee et al.   BRAIN RESEARCH

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

(2008) Lan-Hsin Kuo et al.   MOLECULAR BIOLOGY OF THE CELL