ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization

Diagnosis and Treatment of Parkinson Disease

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ATP13A2 deficiency disrupts lysosomal polyamine export

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ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

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α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis

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The genetics of Parkinson disease

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Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein

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ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function

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α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

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Cell Biology and Pathophysiology of α-Synuclein

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A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death

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Functions of Polyamines in Mammals

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High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease

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 -Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

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Parkinson's disease

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α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)

(2015) Guillaume Daniel et al.   NEUROBIOLOGY OF DISEASE

A lipid switch unlocks Parkinson’s disease-associated ATP13A2

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Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

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Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

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ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

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ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

(2013) Hideaki Matsui et al.   FEBS LETTERS

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

(2013) Taiji Tsunemi et al.   HUMAN MOLECULAR GENETICS

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

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Mapping the Subcellular Distribution of  -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis

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Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis

(2012) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

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Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome

(2012) Anne Grünewald et al.   NEUROBIOLOGY OF AGING

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism

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Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein

(2012) Alexey V. Krasnoslobodtsev et al.   PLoS One

Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9)

(2011) H Eiberg et al.   CLINICAL GENETICS

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Modulation of cellular function by polyamines

(2009) Kazuei Igarashi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

Spermine Binding to Parkinson’s Protein α-Synuclein and Its Disease-Related A30P and A53T Mutants

(2008) Megan Grabenauer et al.   JOURNAL OF PHYSICAL CHEMISTRY B