Therapeutic Agents for Oxaliplatin-Induced Peripheral Neuropathy; Experimental and Clinical Evidence

Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist

(2020) Andrea Bedini et al.   Frontiers in Pharmacology

Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy

(2020) Ana M. Micov et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro

(2020) Nao Shigematsu et al.   Scientific Reports

Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-Induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies

(2020) Anna Furgała - Wojas et al.   CURRENT DRUG METABOLISM

Thrombomodulin alfa prevents oxaliplatin-induced neuropathic symptoms through activation of thrombin-activatable fibrinolysis inhibitor and protein C without affecting anti-tumor activity

(2020) Tatsuro Minami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice

(2020) Kevin M. Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update

(2020) Charles L. Loprinzi et al.   JOURNAL OF CLINICAL ONCOLOGY

Protective effect of cerium oxide nanoparticles on cisplatin and oxaliplatin primary toxicities in male albino rats

(2020) Amira Mohamed Abdelhamid et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity

(2020) Laura Micheli et al.   Neurotherapeutics

Oral administration of Cystine and Theanine ameliorates oxaliplatin-induced chronic peripheral neuropathy in rodents

(2020) Takehiro Kawashiri et al.   Scientific Reports

Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity

(2020) Annalisa Canta et al.   Antioxidants

Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats

(2020) Hamit Celik et al.   NEUROTOXICOLOGY

Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

(2019) Olivier Cerles et al.   Acta Neuropathologica Communications

Neuroprotective Effects of an Aqueous Extract of Forsythia viridissima and Its Major Constituents on Oxaliplatin-Induced Peripheral Neuropathy

(2019) Jin-Mu Yi et al.   MOLECULES

Anti‐allodynic and anti‐inflammatory effects of 17α‐hydroxyprogesterone caproate in oxaliplatin‐induced peripheral neuropathy

(2019) Constanza A. Miguel et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Interventional and preventive effects of aripiprazole and ceftriaxone used alone or in combination on oxaliplatin-induced tactile and cold allodynia in mice

(2019) Kinga Sałat et al.   BIOMEDICINE & PHARMACOTHERAPY

Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents

(2019) Anna Miyagi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain

(2019) Huanbai Wang et al.   Marine Drugs

Minocycline for Symptom Reduction During Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Phase II Randomized Clinical Trial

(2019) Xin Shelley Wang et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

(2019) Takehiro Kawashiri et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Involvement of Endothelin Receptors in Peripheral Sensory Neuropathy Induced by Oxaliplatin in Mice

(2019) Renata Bessa Pontes et al.   NEUROTOXICITY RESEARCH

Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats

(2019) Seunghwan Choi et al.   Toxins

p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice

(2019) Yang Yang et al.   Biomed Research International

Metformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice

(2019) Anamaria Falcão Pereira et al.   NEUROSCIENCE LETTERS

Ameliorative effects of aqueous extract of Forsythiae suspensa fruits on oxaliplatin-induced neurotoxicity in vitro and in vivo

(2019) Jin-Mu Yi et al.   BMC Complementary and Alternative Medicine

Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants

(2019) Maho Tsubota et al.   Journal of Neuroinflammation

Oxaliplatin-induced neuropathy occurs through impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors

(2019) Alberto Potenzieri et al.   PAIN

Improvement of peripheral vascular impairment by a phosphodiesterase type 5 inhibitor tadalafil prevents oxaliplatin-induced peripheral neuropathy in mice

(2019) Takashi Ogihara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Topiramate prevents oxaliplatin-related axonal hyperexcitability and oxaliplatin induced peripheral neurotoxicity.

(2019) Paola Alberti et al.   NEUROPHARMACOLOGY

Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice

(2018) Satoshi Toyama et al.   ACS Chemical Neuroscience

Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy

(2018) Lorenzo Di Cesare Mannelli et al.   BIOMEDICINE & PHARMACOTHERAPY

Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice

(2018) Anna Rapacz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function

(2018) Yang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacopuncture With Scolopendra subspinipes Suppresses Mechanical Allodynia in Oxaliplatin-Induced Neuropathic Mice and Potentiates Clonidine-induced Anti-allodynia Without Hypotension or Motor Impairment

(2018) Seo-Yeon Yoon et al.   JOURNAL OF PAIN

Ergothioneine ameliorates oxaliplatin-induced peripheral neuropathy in rats

(2018) Kentaro Nishida et al.   LIFE SCIENCES

Rosmarinic Acid Mitigates Mitochondrial Dysfunction and Spinal Glial Activation in Oxaliplatin-induced Peripheral Neuropathy

(2018) Aparna Areti et al.   MOLECULAR NEUROBIOLOGY

Involvement of pro-inflammation signal pathway in inhibitory effects of rapamycin on oxaliplatin-induced neuropathic pain

(2018) Zongsheng Duan et al.   Molecular Pain

Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation

(2018) Lorenzo Di Cesare Mannelli et al.   NEUROPHARMACOLOGY

Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy

(2018) F. Resta et al.   NEUROPHARMACOLOGY

Ghrelin agonist HM01 attenuates chemotherapy-induced neurotoxicity in rodent models

(2018) Alessia Chiorazzi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin

(2018) Laura Poupon et al.   NEUROPHARMACOLOGY

Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2 S release in vivo

(2018) Elena Lucarini et al.   PHYTOTHERAPY RESEARCH

Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence

(2018) Laura Micheli et al.   Scientific Reports

Tat-HA-NR2B9c attenuate oxaliplatin-induced neuropathic pain

(2018) Hai-Hui Zhou et al.   EXPERIMENTAL NEUROLOGY

New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats

(2018) Shota Yamamoto et al.   INTERNATIONAL JOURNAL OF CANCER

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

(2018) Leonardo Dini et al.   Frontiers in Pharmacology

Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats

(2017) T. Chaumette et al.   EUROPEAN JOURNAL OF PAIN

Duloxetine Protects against Oxaliplatin-Induced Neuropathic Pain and Spinal Neuron Hyperexcitability in Rodents

(2017) Woojin Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of ninjin’yoeito and ginseng extracts on oxaliplatin-induced neuropathies in mice

(2017) Toshiaki Suzuki et al.   Journal of Natural Medicines

Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy

(2017) Aparna Areti et al.   JOURNAL OF PINEAL RESEARCH

The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain

(2017) Satoshi Toyama et al.   NEUROPEPTIDES

Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT 1A receptor selective agonist, NLX-112 in mouse models of pain

(2017) Kinga Sałat et al.   NEUROPHARMACOLOGY

Effects of natural and synthetic isothiocyanate-based H 2 S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels

(2017) Lorenzo Di Cesare Mannelli et al.   NEUROPHARMACOLOGY

Pregabalin for the Prevention of Oxaliplatin‐Induced Painful Neuropathy: A Randomized, Double‐Blind Trial

(2017) Daniel Ciampi de Andrade et al.   ONCOLOGIST

Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy

(2017) Aparna Areti et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats

(2017) Barbara Tenci et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Herbal Medicine AC591 Prevents Oxaliplatin-Induced Peripheral Neuropathy in Animal Model and Cancer Patients

(2017) Xiaolan Cheng et al.   Frontiers in Pharmacology

Intermittent oxaliplatin (oxali) administration and time-to-treatment-failure (TTF) in metastatic colorectal cancer (mCRC): Final results of the phase III CONcePT trial

(2017) A. Grothey et al.   JOURNAL OF CLINICAL ONCOLOGY

Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

(2017) Lorenzo Di Cesare Mannelli et al.   Scientific Reports

Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug

(2017) Shota Yamamoto et al.   Scientific Reports

Aqueous extract of Lithospermi radix attenuates oxaliplatin-induced neurotoxicity in both in vitro and in vivo models

(2016) Eun-Sang Cho et al.   BMC Complementary and Alternative Medicine

Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice

(2016) Rachel M McQuade et al.   BRITISH JOURNAL OF PHARMACOLOGY

An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy using a combination therapy with goshajinkigan and bushi

(2016) Keita Mizuno et al.   CANCER BIOLOGY & THERAPY

Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain

(2016) Bo Deng et al.   Evidence-based Complementary and Alternative Medicine

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy

(2016) Lorenzo Di Cesare Mannelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension

(2016) Ji-Hee Yeo et al.   INTERNATIONAL JOURNAL OF CANCER

Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain

(2016) Toshiaki Suzuki et al.   JOURNAL OF ETHNOPHARMACOLOGY

Repetitive Acupuncture Point Treatment with Diluted Bee Venom Relieves Mechanical Allodynia and Restores Intraepidermal Nerve Fiber Loss in Oxaliplatin-Induced Neuropathic Mice

(2016) Ji-Hee Yeo et al.   JOURNAL OF PAIN

5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice

(2016) Tsugunobu Andoh et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroprotective effects of melatonin as evidenced by abrogation of oxaliplatin induced behavioral alterations, mitochondrial dysfunction and neurotoxicity in rat brain

(2016) Mohammad Waseem et al.   MITOCHONDRION

Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic Response

(2016) Olivier Cerles et al.   MOLECULAR CANCER THERAPEUTICS

The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats

(2016) Changmin Kim et al.   MOLECULES

Calcium and Magnesium Infusions for the Prevention of Oxaliplatin-Induced Peripheral Neurotoxicity: A Systematic Review

(2016) Berit Jordan et al.   ONCOLOGY

Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis

(2016) Huaping Huang et al.   Wspolczesna Onkologia-Contemporary Oncology

Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice

(2016) Dongxing Li et al.   Toxins

Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice

(2016) Woojin Kim et al.   Toxins

The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats

(2016) Georgia Gris et al.   Scientific Reports

Preventive effect of Goshajinkigan on peripheral neurotoxicity of FOLFOX therapy (GENIUS trial): a placebo-controlled, double-blind, randomized phase III study

(2015) Eiji Oki et al.   International Journal of Clinical Oncology

Protective effects of phosphatidylcholine on oxaliplatin-induced neuropathy in rats

(2015) Sung Tae Kim et al.   LIFE SCIENCES

Possible involvement of the sigma-1 receptor chaperone in chemotherapeutic-induced neuropathic pain

(2015) Mori Tomohisa et al.   SYNAPSE

Analgesic Effects of Bee Venom Derived Phospholipase A2 in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain

(2015) Dongxing Li et al.   Toxins

Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity

(2015) Lorenzo Di Cesare Mannelli et al.   PLoS One

Exenatide Facilitates Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats

(2015) Shunsuke Fujita et al.   PLoS One

Assessment of thermal sensitivity in rats using the thermal place preference test

(2014) David Balayssac et al.   BEHAVIOURAL PHARMACOLOGY

Comparison of the Effects of Single Doses of Elcatonin and Pregabalin on Oxaliplatin-Induced Cold and Mechanical Allodynia in Rats

(2014) Manahito Aoki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Serotonergic modulation in neuropathy induced by oxaliplatin: Effect on the 5HT2C receptor

(2014) Daniela Baptista-de-Souza et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glial role in oxaliplatin-induced neuropathic pain

(2014) Lorenzo Di Cesare Mannelli et al.   EXPERIMENTAL NEUROLOGY

PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects

(2014) Masanobu Tsubaki et al.   INTERNATIONAL JOURNAL OF CANCER

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

(2014) Meng Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

(2014) Masahiro Ohsawa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Contribution of Gi/o Protein to Opioid Antinociception in an Oxaliplatin-Induced Neuropathy Rat Model

(2014) Tomoe Kanbara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat

(2014) Keita Mizuno et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neurotropin® relieves oxaliplatin-induced neuropathy via Gi protein-coupled receptors in the monoaminergic descending pain inhibitory system

(2014) Ken Masuguchi et al.   LIFE SCIENCES

Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice

(2014) Tania E. Schwingel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin

(2014) J. R. Deuis et al.   NEURO-ONCOLOGY

Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain

(2014) Ruggero G. Fariello et al.   NEUROPHARMACOLOGY

Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat

(2014) C.R. Robinson et al.   NEUROSCIENCE

Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve

(2014) Kuniaki Tsutsumi et al.   NEUROSCIENCE RESEARCH

Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARγ Agonism as Preventive Pharmacological Approach

(2014) Matteo Zanardelli et al.   PLoS One

Characterization of Acute and Chronic Neuropathies Induced by Oxaliplatin in Mice and Differential Effects of a Novel Mitochondria-targeted Antioxidant on the Neuropathies

(2013) Satoshi Toyama et al.   ANESTHESIOLOGY

Gosha-jinki-gan reduced oxaliplatin-induced hypersensitivity to cold sensation and its effect would be related to suppression of the expression of TRPM8 and TRPA1 in rats

(2013) Yoshinori Kato et al.   ANTI-CANCER DRUGS

Salmon Calcitonin Reduces Oxaliplatin-Induced Cold and Mechanical Allodynia in Rats

(2013) Manahito Aoki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients

(2013) Catherine H Han et al.   BMC CANCER

Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, double-blind, placebo-controlled trial of goshajinkigan to prevent oxaliplatin-induced neuropathy

(2013) Toru Kono et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Effect of Bee Venom Acupuncture on Oxaliplatin-Induced Cold Allodynia in Rats

(2013) Bong-Soo Lim et al.   Evidence-based Complementary and Alternative Medicine

Oxaliplatin-induced oxidative stress in nervous system-derived cellular models: Could it correlate with in vivo neuropathy?

(2013) L. Di Cesare Mannelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy

(2013) Ellen M. Lavoie Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium and Magnesium to Prevent Oxaliplatin-Induced Sensory Neurotoxicity (N08CB/Alliance)

(2013) Charles L. Loprinzi et al.   JOURNAL OF CLINICAL ONCOLOGY

The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy

(2013) Maria Isabel Azevedo et al.   Molecular Pain

Repeated Administration of Mirtazapine Attenuates Oxaliplatin-Induced Mechanical Allodynia and Spinal NR2B Up-Regulation in Rats

(2013) Xiaoyu Liu et al.   NEUROCHEMICAL RESEARCH

Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: Effects of selective activation

(2013) Lorenzo Di Cesare Mannelli et al.   NEUROPHARMACOLOGY

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

(2013) Kali Janes et al.   PAIN

Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial

(2013) Ying Guo et al.   SUPPORTIVE CARE IN CANCER

Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats

(2012) Manahito Aoki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of Silibinin

(2012) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF PAIN

Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats

(2012) Hikaru Sada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

L Type Ca2+ Channel Blockers Prevent Oxaliplatin-Induced Cold Hyperalgesia and TRPM8 Overexpression in Rats

(2012) Takehiro Kawashiri et al.   Molecular Pain

Inhibition of Ca2+/Calmodulin-Dependent Protein Kinase II Reverses Oxaliplatin-Induced Mechanical Allodynia in Rats

(2012) Masafumi Shirahama et al.   Molecular Pain

Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype NaV1.6-resurgent and persistent current

(2012) R. Sittl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotherapy-induced peripheral neurotoxicity (CIPN): An update

(2011) Andreas A. Argyriou et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents

(2011) Soichiro Ushio et al.   EUROPEAN JOURNAL OF CANCER

Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy

(2011) Huaien Zheng et al.   EXPERIMENTAL NEUROLOGY

The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen

(2011) Masanori Nishioka et al.   International Journal of Clinical Oncology

Involvement of Spinal NR2B-Containing NMDA Receptors in Oxaliplatin-Induced Mechanical Allodynia in Rats

(2011) Yuki Mihara et al.   Molecular Pain

Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model

(2010) Takehiro Kawashiri et al.   EUROPEAN JOURNAL OF PAIN

Intravenous Calcium and Magnesium for Oxaliplatin-Induced Sensory Neurotoxicity in Adjuvant Colon Cancer: NCCTG N04C7

(2010) Axel Grothey et al.   JOURNAL OF CLINICAL ONCOLOGY

Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats

(2010) Nobuaki Egashira et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Transient Receptor Potential Vanilloid 1 is Essential for Cisplatin-Induced Heat Hyperalgesia in Mice

(2010) Lauren E Ta et al.   Molecular Pain

Mice with Cisplatin and Oxaliplatin-Induced Painful Neuropathy Develop Distinct Early Responses to Thermal Stimuli

(2009) Lauren E Ta et al.   Molecular Pain

Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice

(2009) Punam Gauchan et al.   NEUROSCIENCE LETTERS

Oxaliplatin-induced neuropathy in the rat: Involvement of oxalate in cold hyperalgesia but not mechanical allodynia

(2009) Mariko Sakurai et al.   PAIN

Oxaliplatin Acts on IB4-Positive Nociceptors to Induce an Oxidative Stress-Dependent Acute Painful Peripheral Neuropathy

(2008) Elizabeth K. Joseph et al.   JOURNAL OF PAIN

The effects of oxaliplatin, an anticancer drug, on potassium channels of the peripheral myelinated nerve fibres of the adult rat

(2008) Alexia Kagiava et al.   NEUROTOXICOLOGY