Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 124, Issue 4, Pages 514-517Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.13249SC
Keywords
oxaliplatin; acute peripheral neuropathy; analgesic
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Funding
- Ministry of Education, Culture, Sport, Science and Technology of Japan [25670285]
- Salt Science Research Foundation [13C4]
- Grants-in-Aid for Scientific Research [24111527, 26293019, 25670285] Funding Source: KAKEN
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Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.
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