Cell-to-Cell Communication by Host-Released Extracellular Vesicles in the Gut: Implications in Health and Disease

An emerging focus on lipids in extracellular vesicles

(2020) Tore Skotland et al.   ADVANCED DRUG DELIVERY REVIEWS

Serum Biomarkers for Inflammatory Bowel Disease

(2020) Peng Chen et al.   Frontiers in Medicine

HucMSC‐exosomes carrying miR‐326 inhibit neddylation to relieve inflammatory bowel disease in mice

(2020) Gaoying Wang et al.   Clinical and Translational Medicine

Extracellular vesicles in inflammatory bowel disease: small particles, big players

(2020) M Valter et al.   Journal of Crohns & Colitis

M2 macrophage-derived exosomal-miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1/YAP/β-catenin signalling axis

(2020) Feihong Deng et al.   Journal of Crohns & Colitis

MSC-derived exosomal miR-34a/c-5p and miR-29b-3p improve intestinal barrier function by targeting the Snail/Claudins signaling pathway

(2020) Yi-Yun Li et al.   LIFE SCIENCES

Olfactory Ecto-Mesenchymal Stem Cell-Derived Exosomes Ameliorate Experimental Colitis via Modulating Th1/Th17 and Treg Cell Responses

(2020) Jie Tian et al.   Frontiers in Immunology

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

(2019) Veronika Butin-Israeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein composition reflects extracellular vesicle heterogeneity

(2019) Tatyana Vagner et al.   PROTEOMICS

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization

(2019) Li Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Postprandial Circulating miRNAs in Response to a Dietary Fat Challenge

(2019) Diana C. Mantilla-Escalante et al.   Nutrients

MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells

(2019) Kyriaki Bakirtzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Circulating Exosomal miR-150-5p and miR-99b-5p as Diagnostic Biomarkers for Colorectal Cancer

(2019) Ya jing Zhao et al.   Frontiers in Oncology

Cancer-Derived Extracellular Vesicle-Associated MicroRNAs in Intercellular Communication: One Cell’s Trash Is Another Cell’s Treasure

(2019) Joseph Mills et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

(2019) Carl Randall Harrell et al.   Cells

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

(2018) Marthe F.S. Lindenbergh et al.   Annual Review of Immunology

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

MicroRNA miR-223 as regulator of innate immunity

(2018) Xiaoyi Yuan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction

(2018) Mitsuaki Kojima et al.   Journal of Trauma and Acute Care Surgery

MicroRNA-21 is upregulated during intestinal barrier dysfunction induced by ischemia reperfusion

(2018) Lin Zhang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biogenesis and function of ESCRT-dependent extracellular vesicles

(2018) Thomas Juan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The biology of extracellular microvesicles

(2018) Alanna E. Sedgwick et al.   TRAFFIC

Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

(2018) Xu Zhang et al.   Nature Communications

Faecal microRNAs: indicators of imbalance at the host-microbe interface?

(2018) G.M. Moloney et al.   Beneficial Microbes

Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction

(2018) Mitsuaki Kojima et al.   Journal of Trauma and Acute Care Surgery

Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment

(2018) Alireza Tahamtan et al.   Frontiers in Immunology

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

MiRNAs and inflammatory bowel disease: An interesting new story

(2018) Soheila Moein et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

EVmiRNA: a database of miRNA profiling in extracellular vesicles

(2018) Teng Liu et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense

(2018) Carmen Aguilar et al.   TRENDS IN MICROBIOLOGY

MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-κB pathway

(2017) Xuemei He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Potential roles of neutrophils in regulating intestinal mucosal inflammation of inflammatory bowel disease

(2017) Guang Xi Zhou et al.   Journal of Digestive Diseases

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

(2017) Viola Neudecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing

(2017) Thomas W. Slater et al.   JOURNAL OF IMMUNOLOGY

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake

(2017) Kinsley C. French et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression

(2017) Zhan-Jun Lu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Characterization of mouse serum exosomal small RNA content: The origins and their roles in modulating inflammatory response

(2017) Xin Zhou et al.   Oncotarget

Microbiota alteration is associated with the development of stress-induced despair behavior

(2017) Ioana A. Marin et al.   Scientific Reports

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

(2017) Fei Mao et al.   Biomed Research International

MicroRNAs-Based Inter-Domain Communication between the Host and Members of the Gut Microbiome

(2017) Maggie R. Williams et al.   Frontiers in Microbiology

Small Luggage for a Long Journey: Transfer of Vesicle-Enclosed Small RNA in Interspecies Communication

(2017) Fabio A. Lefebvre et al.   Frontiers in Microbiology

Exosomes Derived from Dendritic Cells Treated with Schistosoma japonicum Soluble Egg Antigen Attenuate DSS-Induced Colitis

(2017) Lifu Wang et al.   Frontiers in Pharmacology

Intestinal Bacteria Composition and Translocation of Bacteria in Inflammatory Bowel Disease

(2017) Spyros Vrakas et al.   PLoS One

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase

(2017) Hanna Ungewiß et al.   Scientific Reports

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

The Host Shapes the Gut Microbiota via Fecal MicroRNA

(2016) Shirong Liu et al.   Cell Host & Microbe

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration

(2016) Veronika Butin-Israeli et al.   FASEB JOURNAL

Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease

(2016) Nóra J. Béres et al.   INFLAMMATORY BOWEL DISEASES

Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages

(2016) Shuji Mitsuhashi et al.   INFLAMMATORY BOWEL DISEASES

Wnt-expressing cells in the intestines: guides for tissue remodeling

(2016) Hiroyuki Miyoshi   JOURNAL OF BIOCHEMISTRY

MicroRNA-132 and microRNA-223 control positive feedback circuit by regulating FOXO3a in inflammatory bowel disease

(2016) Hye-Youn Kim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The role of Gut Microbiota in the development of obesity and Diabetes

(2016) Othman A. Baothman et al.   Lipids in Health and Disease

Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease

(2016) Huiling Wang et al.   MEDICINE

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic profiling of dextran sulfate sodium induced acute ulcerative colitis mice serum exosomes and their immunomodulatory impact on macrophages

(2016) Wing-Yan Wong et al.   PROTEOMICS

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

(2016) Jonathan Landy et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

(2016) Jan Rossaint et al.   Nature Communications

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

(2016) Lingling Jiang et al.   Nature Communications

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

(2016) Subhrajit Saha et al.   Nature Communications

Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice

(2016) Yungang Wang et al.   Oncotarget

MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting

(2016) Ting Tian et al.   Scientific Reports

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

MicroRNA-21 regulates intestinal epithelial tight junction permeability

(2015) Lin Zhang et al.   CELL BIOCHEMISTRY AND FUNCTION

Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease

(2015) B. B. Williams et al.   Disease Models & Mechanisms

MicroRNA 29 Targets Nuclear Factor-κB–Repressing Factor and Claudin 1 to Increase Intestinal Permeability

(2015) QiQi Zhou et al.   GASTROENTEROLOGY

Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

(2015) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Mass-Spectrometry-Based Molecular Characterization of Extracellular Vesicles: Lipidomics and Proteomics

(2015) Simion Kreimer et al.   JOURNAL OF PROTEOME RESEARCH

Wound repair: role of immune–epithelial interactions

(2015) G Leoni et al.   Mucosal Immunology

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic Cells and Macrophages by Targeting C/EBPβ

(2015) Haibo Zhou et al.   Cell Reports

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis

(2015) Jia Yang et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

(2014) Thassila Pitanga et al.   BMC CELL BIOLOGY

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

MiR-874 promotes intestinal barrier dysfunction through targeting AQP3 following intestinal ischemic injury

(2014) Xiaofei Zhi et al.   FEBS LETTERS

miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD

(2014) Wei Wu et al.   GUT

miR-155 deficiency protects mice from experimental colitis by reducing T helper type 1/type 17 responses

(2014) Udai P. Singh et al.   IMMUNOLOGY

Galectin-3 Regulates Desmoglein-2 and Intestinal Epithelial Intercellular Adhesion

(2014) Kun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A1 Regulates Intestinal Mucosal Injury, Inflammation, and Repair

(2014) B. A. Babbin et al.   JOURNAL OF IMMUNOLOGY

Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells

(2014) C. Eken et al.   JOURNAL OF IMMUNOLOGY

Proteomics of extracellular vesicles: Exosomes and ectosomes

(2014) Dong-Sic Choi et al.   MASS SPECTROMETRY REVIEWS

Galectin‐3, a Biomarker Linking Oxidative Stress and Inflammation With the Clinical Outcomes of Patients With Atherothrombosis

(2014) Julio Madrigal‐Matute et al.   Journal of the American Heart Association

Wound healing and the role of fibroblasts

(2014) Bainbridge P.   Journal of Wound Care

TNF-α Modulation of Intestinal Epithelial Tight Junction Barrier Is Regulated by ERK1/2 Activation of Elk-1

(2013) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases

(2013) M. Svrcek et al.   CARCINOGENESIS

MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-κB and improving epithelial barrier function

(2013) Toshie Nata et al.   JOURNAL OF GENE MEDICINE

MicroRNA-21 Knockout Improve the Survival Rate in DSS Induced Fatal Colitis through Protecting against Inflammation and Tissue Injury

(2013) Chenzhang Shi et al.   PLoS One

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense

(2013) Guoku Hu et al.   PLoS Pathogens

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease

(2012) Constance S.V. Petit et al.   GASTROENTEROLOGY

Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages

(2012) Ceylan Eken et al.   IMMUNOBIOLOGY

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

(2012) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF- 1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

(2012) F. T. Borges et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis

(2012) Kathrin Ludwig et al.   VIRCHOWS ARCHIV

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability

(2011) Dongmei Ye et al.   GASTROENTEROLOGY

Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40

(2011) X. Xue et al.   JOURNAL OF IMMUNOLOGY

Intestinal epithelial cell-derived integrin αβ6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response

(2011) Xiao Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of microRNAs associated with ileal and colonic Crohnʼs disease†

(2010) Feng Wu et al.   INFLAMMATORY BOWEL DISEASES

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration

(2010) Julia Esser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

(2010) Michael J. Davies   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome

(2009) Q. Zhou et al.   GUT

A33 antigen-deficient mice have defective colonic mucosal repair

(2009) Prue M. Pereira-Fantini et al.   INFLAMMATORY BOWEL DISEASES

Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)

(2009) Mireya Gonzalez-Begne et al.   JOURNAL OF PROTEOME RESEARCH

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α

(2008) Feng Wu et al.   GASTROENTEROLOGY