A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway

Inhibition of inflammatory mediators and cell migration by 1,2,3,4-tetrahydroquinoline derivatives in LPS-stimulated BV2 microglial cells via suppression of NF-κB and JNK pathway

(2020) Bich Phuong Bui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

(2020) Ha Thi Thu Do et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View

(2020) Manuela Labbozzetta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems

(2020) Naoki Abe et al.   Cells

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

(2019) Morena Zusso et al.   Journal of Neuroinflammation

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

(2019) Gunnar R. Leitner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells

(2018) Yingbo He et al.   Journal of Neuroinflammation

Antioxidant and Neuroprotective Effects of N-((3,4-Dihydro-2H-benzo[h]chromen-2-yl)methyl)-4-methoxyaniline in Primary Cultured Rat Cortical Cells: Involvement of ERK-CREB Signaling

(2018) Kyeongjun Lee et al.   MOLECULES

An Overview of in vitro Methods to Study Microglia

(2018) Raissa Timmerman et al.   Frontiers in Cellular Neuroscience

Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)

(2018) Starlee Lively et al.   Frontiers in Cellular Neuroscience

A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α

(2017) Sharifah Alawieyah Syed Mortadza et al.   GLIA

Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NF-κB and JAK–STAT Pathway

(2017) Qasim Alhadidi et al.   MOLECULAR NEUROBIOLOGY

Effect of CCL2 on BV2 microglial cell migration: Involvement of probable signaling pathways

(2016) Shambhunath Bose et al.   CYTOKINE

The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice

(2016) Md. Moniruzzaman et al.   JOURNAL OF ETHNOPHARMACOLOGY

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

(2016) Takuya Iizumi et al.   Journal of Neuroinflammation

HNO suppresses LPS-induced inflammation in BV-2 microglial cells via inhibition of NF-κB and p38 MAPK pathways

(2016) Yebo Zhou et al.   PHARMACOLOGICAL RESEARCH

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Methionine Sulfoxide Reductase A Negatively Controls Microglia-Mediated Neuroinflammation via Inhibiting ROS/MAPKs/NF-κB Signaling Pathways Through a Catalytic Antioxidant Function

(2015) Hua Fan et al.   ANTIOXIDANTS & REDOX SIGNALING

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

(2015) G.Z. Réus et al.   NEUROSCIENCE

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Biochanin A attenuates LPS-induced pro-inflammatory responses and inhibits the activation of the MAPK pathway in BV2 microglial cells

(2014) WANG-YANG WU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways

(2014) Xiaoxiao Wang et al.   NEUROPHARMACOLOGY

Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases

(2014) Mehdi Ghasemi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Microglial migration mediated by ATP-induced ATP release from lysosomes

(2012) Ying Dou et al.   CELL RESEARCH

Neuroprotective effect of raspberry extract by inhibiting peroxynitrite-induced DNA damage and hydroxyl radical formation

(2012) Wei Chen et al.   FOOD RESEARCH INTERNATIONAL

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia

(2012) Ke-Wu Zeng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evaluating the role of Toll-like receptors in diseases of the central nervous system

(2011) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

Astrocytes and Microglia: Responses to Neuropathological Conditions

(2011) Sarika Singh et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

NO mediates microglial response to acute spinal cord injury under ATP control in vivo

(2010) Payam Dibaj et al.   GLIA

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity

(2009) Giorgio Roma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

ATP and NO dually control migration of microglia to nerve lesions

(2008) Yuanli Duan et al.   Developmental Neurobiology

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE