Review
Engineering, Environmental
Fang Liu, Chunyan Liu, Yin Liu, Jiahui Wang, Yibing Wang, Bing Yan
Summary: Exposure to PM2.5 is linked to increased incidence of CNS diseases in humans, shown by multiple epidemiological studies. Animal models confirm that PM2.5 exposure can harm brain tissue and contribute to neurodevelopmental and neurodegenerative diseases. Both animal and human cell models indicate that oxidative stress and inflammation are the main toxic effects of PM2.5 exposure. However, understanding how PM2.5 affects neurotoxicity is challenging due to its complex and variable composition.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Linhua Wei, Weiwei Chen, Linke Huang, Hui Wang, Yuangang Su, Jiamin Liang, Haoyu Lian, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: This study explored the effects and mechanism of Alpinetin (Alp) on inflammatory osteolysis. The results showed that Alp suppressed the differentiation and function of osteoclasts, reduced reactive oxygen species production, and inhibited the expression of inflammatory genes. Moreover, Alp inhibited the phosphorylation of specific pathways and minimized LPS-induced osteolysis in mice.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jieun Kim, Hyun-ju Lee, Seon Kyeong Park, Jin-Hee Park, Ha-Ram Jeong, Soojung Lee, Heeyong Lee, Eunyoung Seol, Hyang-Sook Hoe
Summary: The study demonstrated that donepezil significantly reduces LPS- and A beta-induced neuroinflammatory responses in vitro and in vivo, suggesting it may be a therapeutic agent for neuroinflammation-associated diseases such as Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ilandarage Menu Neelaka Molagoda, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Mi-Hwa Lee, Chang-Hee Kang, Kyoung Tae Lee, Yung Hyun Choi, Seunghun Lee, Gi-Young Kim
Summary: Acertannin (ACTN), a polyphenol with powerful anticancer and antioxidant effects, has been found to have anti-inflammatory effects. ACTN attenuates proinflammatory cytokines and mediators by inhibiting NF-Kappa B activation, reduces ROS production, and disrupts the binding of LPS to the TLR4/MD2 complex. It also inhibits the recruitment of intracellular adaptor proteins and attenuates NF-Kappa B-mediated inflammatory responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Federica Mannino, Giovanni Pallio, Chiara Imbesi, Alessandro Scarfone, Domenico Puzzolo, Antonio Micali, Jose Freni, Francesco Squadrito, Alessandra Bitto, Letteria Minutoli, Natasha Irrera
Summary: The present study evaluated the effects of beta-Caryophyllene (BCP) on Cd-induced neurotoxicity. The results showed that BCP treatment reduced ROS production, increased Nrf2 expression, and protected cells from death. BCP also regulated the apoptosis pathway and reduced the increase of pro-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tingting Li, Lin Yuan, Yijing Zhao, Zige Jiang, Chengcheng Gai, Danqing Xin, Hongfei Ke, Xiaofan Guo, Wenqiang Chen, Dexiang Liu, Zhen Wang, Cyrus S. H. Ho
Summary: Neuroinflammation is important in the development of major depressive disorder, and osteopontin (OPN) plays a key role in neuroinflammation. This study demonstrates the crucial role of OPN in lipopolysaccharide-induced depressive-like behavior.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Oscar Manouchehrian, Marta Ramos, Sara Bachiller, Iben Lundgaard, Tomas Deierborg
Summary: The study aimed to measure the effect of acute inflammation on the glymphatic system by analyzing the distribution of CSF tracers after LPS injections. The results showed a significant decrease in perivascular CSF tracer flow and penetration into the parenchyma following LPS injections, without impacting AQP4 polarization, cytokines, astroglial and BBB markers, cerebral blood flow, or respiration.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Seung-Woo Kim, Sang-A Oh, Song- Seol, Dashdulam Davaanyam, Ja-Kyeong Lee
Summary: The study found that HMGB1 plays a critical role in mediating NOD2-induced autophagy in microglia. Cytoplasmic accumulation of HMGB1 activates a cell-autonomous pro-autophagic pathway, while extracellular secretion of HMGB1 activates a cell-autonomous pro-inflammatory pathway.
Article
Plant Sciences
Defang Ren, Yu Fu, Li Wang, Jianqin Liu, Xia Zhong, Jiyuan Yuan, Chaoli Jiang, Honglian Wang, Zhi Li
Summary: In this study, it was demonstrated that tetrandrine ameliorates Alzheimer's disease by suppressing microglia-mediated inflammation and neurotoxicity.
Article
Immunology
Eoin O'Neill, Eadaoin W. Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningham
Summary: Experimental evidence demonstrates that significant depletion of noradrenaline in the hippocampus and frontal cortex does not lead to acutely exaggerated neuroinflammation, nor does it leave the brain susceptible to acute, transient working memory deficits upon low dose LPS challenge.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Lan Wang, Danfeng Zhao, Huan Wang, Lele Wang, Xiaohui Liu, Haiyan Zhang
Summary: FPS-ZM1 was found to inhibit LPS-induced microglial inflammation, with the possible mechanism involving the JAK/STAT signaling pathway. The study demonstrated the anti-inflammatory effects of FPS-ZM1 in both in vivo and in vitro models.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Riccardo De Marco, Itamar Ronen, Francesca Branzoli, Marisa L. Amato, Iris Asllani, Alessandro Colasanti, Neil A. Harrison, Mara Cercignani
Summary: This study demonstrated that DW-MRS may be a powerful tool sensitive to glial cytomorphological changes induced by systemic inflammation. The ADC of the glial metabolite choline was found to significantly increase after LPS administration, with changes in mood ratings.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Pharmacology & Pharmacy
Ana M. Espinosa-Oliva, Pablo Garcia-Miranda, Isabel Maria Alonso-Bellido, Ana E. Carvajal, Melania Gonzalez-Rodriguez, Alejandro Carrillo-Jimenez, Arturo J. Temblador, Manuel Felices-Navarro, Irene Garcia-Dominguez, Maria Angustias Roca-Ceballos, Maria D. Vazquez-Carretero, Juan Garcia-Revilla, Marti Santiago, Maria J. Peral, Jose Luis Venero, Rocio M. de Pablos
Summary: Peripheral inflammation, particularly originating in the colon, is emerging as a significant predisposing factor for Parkinson's disease. Deletion of galectin-3 effectively reduces neuroinflammation in acute peripheral inflammation models, indicating a central regulatory role of galectin-3 in microglial activation induced by peripheral inflammation. Modulation of galectin-3 function could be a promising strategy to minimize undesirable microglia polarization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Nandan Wu, Qian Luo, Yuke Huang, Linxi Wan, Xiangtao Hou, Zihua Jiang, Yan Li, Jin Qiu, Pei Chen, Keming Yu, Jing Zhuang, Ying Yang
Summary: This study demonstrates that lithium chloride (LiCl) exerts anti-inflammatory and neuroprotective effects by inhibiting microglial activation via the PI3K/Akt/NF-KB pathway in LPS-induced retinal injury. LiCl provides a novel and promising option to treat retinal inflammatory diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Clinical Neurology
Lei Shi, Zhu Xia, Jiamei Guo, Lixia Wang, Zhiping Peng, Dachuan Qiu, Yi Zhou, Dongdong Zhou, Li Kuang, Tian Qiu
Summary: This study investigates the effects of Maresin-1 on depression and neuroinflammation, finding that it can partially relieve depressive-like behaviors induced by lipopolysaccharide. It is also discovered that this effect is related to its anti-inflammatory action on microglia.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Medicinal
Austin Horton, Kevin Nash, Ethel Tackie-Yarboi, Alexander Kostrevski, Adam Novak, Aparna Raghavan, Jatin Tulsulkar, Qasim Alhadidi, Nathan Wamer, Bryn Langenderfer, Kalee Royster, Maxwell Ducharme, Katelyn Hagood, Megan Post, Zahoor A. Shah, Isaac T. Schiefer
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Correction
Chemistry, Medicinal
Austin Horton, Kevin Nash, Ethel Tackie-Yarboi, Alexander Kostrevski, Adam Novak, Aparna Raghavan, Jatin Tulsulkar, Qasim Alhadidi, Nathan Warner, Bryn Langenderfer, Kalee Royster, Maxwell Ducharme, Katelyn Hagood, Megan Post, Zahoor A. Shah, Isaac T. Schiefer
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Plant Sciences
Saroopa P. Samaradivakara, Radhika Samarasekera, Shiroma M. Handunnetti, O. V. D. S. Jagathpriya Weerasena, Ayad A. Al-Hamashi, James T. Slama, William R. Taylor, Qasim Alhadid, Zahoor A. Shah, Lalith Perera, L. M. Viranga Tillekeratne
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Biochemistry & Molecular Biology
R. Ranjithkumar, Qasim Alhadidi, Zahoor A. Shah, Muthiah Ramanathan
NEUROCHEMICAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Yusuf S. Althobaiti, Atiah Almalki, Hashem Alsaab, Walaa Alsanie, Ahmed Gaber, Qasim Alhadidi, Ana Maria Gregio Hardy, Abdulrahman Nasr, Omar Alzahrani, Creed M. Stary, Zahoor A. Shah
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Qasim Alhadidi, Lijun Xu, Xiaoyun Sun, Yusuf Althobaiti, Atiah Almalki, Hashem Alsaab, Creed Stary
Article
Multidisciplinary Sciences
Walaa F. Alsanie, Ola A. Bahri, Hamza H. Habeeballah, Majid Alhomrani, Mazen M. Almehmadi, Khalaf Alsharif, Ebaa M. Felemban, Yusuf S. Althobaiti, Atiah H. Almalki, Hashem O. Alsaab, Ahmed Gaber, Mohamed M. Hassan, Ana Maria Gregio Hardy, Qasim Alhadidi
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Ghaith A. Bahader, Kevin M. Nash, Daniyah A. Almarghalani, Qasim Alhadidi, Marcia F. McInerney, Zahoor A. Shah
Summary: The study demonstrates that diabetes mellitus exacerbates the outcomes of hemorrhagic stroke, including increased hematoma volume and deficits in post-stroke locomotor, sensorimotor, and cognitive behavior. This research contributes to a better understanding of the impact of diabetes comorbidity on hemorrhagic stroke outcomes and reveals the important pathological mechanisms underlying diabetes-induced exacerbation of ICH injury.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Saleh Alaqel, Samkeliso Dlamini, Daniyah A. Almarghalani, Arjun Shettigar, Qasim Alhadidi, Sinali H. Kodithuwakku, Creed Stary, L. M. Viranga Tillekeratne, Zahoor A. Shah
Summary: This study designed and synthesized a cofilin small-molecule inhibitor for targeting secondary complications of ICH and found that the compound SZ-3 showed potent anti-neuroinflammation activity.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Qasim M. Alhadidi, Lijun Xu, Xiaoyun Sun, Yusuf S. Althobaiti, Atiah Almalki, Hashem O. Alsaab, Creed M. Stary
Summary: Ischemic stroke is a devastating cerebrovascular disease, and research suggests that miR-182 plays a crucial role in stroke injury and recovery. Inhibition of miR-182 has been found to protect mitochondrial structure, mitigate neuroinflammation, and reduce cell death.
NEUROCHEMICAL RESEARCH
(2022)
Article
Agricultural Engineering
Gavini Dilkhushi Liyanaararchchi, Anton Sameera Perera, Jayanetti Koralalage Ramani Radhika Samarasekera, Kariyawasam Ranaweerage Ranjith Mahanama, Kirihettiliyanage Don Patrick Hemalal, Samkeliso Dlamini, Hettiarachchige Dona Sachindra Melshandi Perera, Qasim Alhadidi, Zahoor A. Shah, L. M. Viranga Tillekeratne
Summary: Two novel compounds were isolated from the stem bark of A. nobilis. They exhibited potential as depigmenting and anti-inflammatory agents, showing significant inhibitory activities against tyrosinase, A5-lipoxygenase, and nitric oxide production.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Pharmacology & Pharmacy
Saad Hussain, Qasim Mahmood Alhadidi
Summary: Cancer is the leading cause of death globally, and metastasis is a major obstacle in cancer treatment. Polyphenols, natural chemical compounds with antioxidant properties, are commonly used in cancer prevention and adjuvant therapies. The tyrosine kinase pathway plays a role in the metastatic cascade, and polyphenols can decrease tyrosine kinase activity to inhibit metastasis.
INDONESIAN JOURNAL OF PHARMACY
(2022)
Article
Health Care Sciences & Services
Atiah H. Almalki, Hashem O. Alsaab, Walaa F. Alsanie, Ahmed Gaber, Turki Alkhalifa, Ahmad Almalki, Omar Alzahrani, Ana Maria Gregio Hardy, Qasim Alhadidi, Zahoor A. Shah, Yusuf S. Althobaiti
Summary: Pregabalin, a drug of abuse, induces conditioned place preference, while N-acetylcysteine can block pregabalin-seeking behaviors. The study results demonstrate the important role of glutamate transporters in pregabalin abuse.
Meeting Abstract
Clinical Neurology
Zahoor Shah, Qasim Alhadidi