Design, synthesis, characterization, enzymatic inhibition evaluations, and docking study of novel quinazolinone derivatives

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

(2020) Adel S. El-Azab et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

An update on drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

(2020) Claudiu T. Supuran   Expert Opinion on Drug Metabolism & Toxicology

Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs

(2020) Nebih Lolak et al.   BIOORGANIC CHEMISTRY

2,4-Dioxochroman moiety linked to 1,2,3-triazole derivatives as novel α-glucosidase inhibitors: Synthesis, in vitro biological evaluation, and docking study

(2020) Marjan Mollazadeh et al.   CURRENT ORGANIC CHEMISTRY

Synthesis and anticancer evaluation of novel 1,4-naphthoquinone derivatives containing a phenylamino-sulfanyl moiety

(2019) Dong Jin Yoo et al.   ChemMedChem

Phytochemical content, antioxidant activity, and enzyme inhibition effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

(2019) Ercan Bursal et al.   JOURNAL OF FOOD BIOCHEMISTRY

Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones

(2019) Umit M. Kocyigit et al.   MONATSHEFTE FUR CHEMIE

The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

(2019) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Anticancer and DNA binding studies of potential amino acids based quinazolinone analogs: Synthesis, SAR and molecular docking

(2019) K.P. Rakesh et al.   BIOORGANIC CHEMISTRY

The significance of N-methylpicolinamides in the development of anticancer therapeutics: Synthesis and structure-activity relationship (SAR) studies

(2019) Balakrishna Moku et al.   BIOORGANIC CHEMISTRY

Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases

(2019) Burak Kuzu et al.   BIOORGANIC CHEMISTRY

Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors

(2019) Fikret Turkan et al.   BIOORGANIC CHEMISTRY

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes

(2019) Kaan Kucukoglu et al.   BIOORGANIC CHEMISTRY

Anti‐diabetic properties of dietary phenolic compounds: Inhibition effects on α‐Amylase, Aldose Reductase and α‐Glycosidase

(2019) Yeliz Demir et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Sage (Salvia pilifera): determination of its polyphenol contents, anticholinergic, antidiabetic and antioxidant activities

(2019) İlhami Gülçin et al.   Journal of Food Measurement and Characterization

Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors

(2019) Adel S. El-Azab et al.   BIOORGANIC CHEMISTRY

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

(2019) Wan-Yin Fang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amino acids conjugated quinazolinone-Schiff’s bases as potential antimicrobial agents: Synthesis, SAR and molecular docking studies

(2019) K.P. Rakesh et al.   BIOORGANIC CHEMISTRY

Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials

(2019) Parham Taslimi et al.   BIOORGANIC CHEMISTRY

Benzoylquinazolinone derivatives as new potential antidiabetic agents: α‐Glucosidase inhibition, kinetic, and docking studies

(2019) Maryam Mohammadi‐Khanaposhtani et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Synthesis and biological evaluation of phloroglucinol derivatives possessing α-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity

(2018) Serdar Burmaoglu et al.   ARCHIV DER PHARMAZIE

Multi-targetable chalcone analogs to treat deadly Alzheimer’s disease: Current view and upcoming advice

(2018) Xu Zhang et al.   BIOORGANIC CHEMISTRY

New 6-amino-pyrido[2,3- d ]pyrimidine-2,4-diones as novel agents to treat type 2 diabetes: A simple and efficient synthesis, α -glucosidase inhibition, molecular modeling and kinetic study

(2018) Mehdi Adib et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sulfonamide inhibitors: a patent review 2013-present

(2018) İlhami Gulçin et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes inhibitors: The novel N ,N ′-bis-cyanomethylamine and alkoxymethylamine derivatives

(2018) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Antioxidant and anticholinergic properties of olivetol

(2018) Parham Taslimi et al.   JOURNAL OF FOOD BIOCHEMISTRY

2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, α-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties

(2018) Fatoş Erdemir et al.   JOURNAL OF MOLECULAR STRUCTURE

Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery

(2018) Chuang Zhao et al.   RSC Advances

The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats

(2018) Fikret Türkan et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Novel Benzylic Substituted Imidazolinium, Tetrahydropyrimidinium and Tetrahydrodiazepinium Salts: Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors

(2018) Beyhan Yiğit et al.   ChemistrySelect

Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia

(2018) Parham Taslimi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid

(2018) Mansura Huseynova et al.   POLYHEDRON

Screening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extract

(2018) N. Eruygur et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

(2018) Yeliz Demir et al.   ARCHIV DER PHARMAZIE

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

(2018) Chuang Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach

(2018) Cuneyt Caglayan et al.   JOURNAL OF FOOD BIOCHEMISTRY

Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors

(2018) Salih Ökten et al.   JOURNAL OF MOLECULAR STRUCTURE

Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition

(2018) Beyhan Yiğit et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity

(2018) Dilan Ozmen Ozgun et al.   BIOORGANIC CHEMISTRY

Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes

(2018) Mansura Huseynova et al.   BIOORGANIC CHEMISTRY

Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study

(2018) Mina Saeedi et al.   BIOORGANIC CHEMISTRY

Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on α-glycosidase and α-amylase enzymes

(2017) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Synephrine and phenylephrine act as α-amylase, α-glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors

(2017) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study

(2017) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

(2017) Shagufta Shagufta et al.   MedChemComm

Design, synthesis and cytotoxic evaluation of novel imidazolone fused quinazolinone derivatives

(2017) Deepak Kumar et al.   Arabian Journal of Chemistry

Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds

(2016) Bünyamin Özgeriş et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quinazolinones–Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents

(2016) Jyothsna Devi Palem et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR studies of potent H+/K+-ATPase inhibitors of quinazolinone-Schiff’s base analogues

(2016) K.P. Rakesh et al.   BIOORGANIC CHEMISTRY

Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

(2016) Fadime Özbey et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Schiff’s bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants

(2015) K.P. Rakesh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, molecular docking and biological evaluation of novel 6-(4-(4-aminophenylsulfonyl)phenylamino)-5H-benzo[a]phenothiazin-5-one derivatives

(2015) Palanisamy Ravichandiran et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways

(2015) Maryam Zahedifard et al.   Scientific Reports

Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode

(2014) Fouad H. Darras et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitory properties of novel benzylsulfamides using molecular modeling and experimental studies

(2014) Süleyman Göksu et al.   BIOORGANIC CHEMISTRY

Synthesis, molecular docking and cytotoxicity evaluation of novel 2-(4-amino-benzosulfonyl)-5H-benzo[b]carbazole-6,11-dione derivatives as histone deacetylase (HDAC8) inhibitors

(2014) P. Ravichandiran et al.   BIOORGANIC CHEMISTRY

Synthesis and Carbonic Anhydrase Isoenzymes I, II, IX, and XII Inhibitory Effects of Dimethoxybromophenol Derivatives Incorporating Cyclopropane Moieties

(2014) Murat Boztaş et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, molecular docking as histone deacetylase (HDAC8) inhibitors, cytotoxicity and antibacterial evaluation of novel 6-(4-(4-aminophenylsulfonyl)phenylamino)-5H-benzo[a]phenoxazin-5-one derivatives

(2014) P. Ravichandiran et al.   MEDICINAL CHEMISTRY RESEARCH

Structure-Based Search for New Inhibitors of Cholinesterases

(2013) Marek Bajda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid screening and identification ofα-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR

(2012) Yi Tao et al.   BIOMEDICAL CHROMATOGRAPHY

Quinazoline derivatives as potential anticancer agents: a patent review (2007 – 2010)

(2012) Giovanni Marzaro et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives

(2012) Mert Olgun Karatas et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors

(2010) Anna Więckowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors

(2010) Bin Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY