Human Intestinal Macrophages Are Involved in the Pathology of Both Ulcerative Colitis and Crohn Disease

Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn’s disease

(2019) Laurence Chapuy et al.   Mucosal Immunology

Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise

(2018) Palak J Trivedi et al.   Journal of Crohns & Colitis

TNF-anti-TNF Immune Complexes Inhibit IL-12/IL-23 Secretion by Inflammatory Macrophages via an Fc-dependent Mechanism

(2018) Felicia M Bloemendaal et al.   Journal of Crohns & Colitis

Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease

(2018) D. Bernardo et al.   Mucosal Immunology

RNA-seq Reveals Transcriptomic Differences in Inflamed and Noninflamed Intestinal Mucosa of Crohnʼs Disease Patients Compared with Normal Mucosa of Healthy Controls

(2017) Sung Noh Hong et al.   INFLAMMATORY BOWEL DISEASES

An Overview of the Innate and Adaptive Immune System in Inflammatory Bowel Disease

(2017) Matthew C. Choy et al.   INFLAMMATORY BOWEL DISEASES

TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice

(2017) Tunay Kökten et al.   Journal of Crohns & Colitis

An Antibody Against Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) Dampens Proinflammatory Cytokine Secretion by Lamina Propria Cells from Patients with IBD

(2016) Siggeir F. Brynjolfsson et al.   INFLAMMATORY BOWEL DISEASES

B-Cell Dysregulation in Crohn's Disease Is Partially Restored with Infliximab Therapy

(2016) Wilhelmina M. C. Timmermans et al.   PLoS One

High-Resolution Gene Expression Profiling Using RNA Sequencing in Patients With Inflammatory Bowel Disease and in Mouse Models of Colitis

(2015) Kristine Holgersen et al.   Journal of Crohns & Colitis

The monocyte-macrophage axis in the intestine

(2014) Calum C. Bain et al.   CELLULAR IMMUNOLOGY

Infliximab therapy increases the frequency of circulating CD16+monocytes and modifies macrophage cytokine response to bacterial infection

(2014) N. Nazareth et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases

(2014) Silvio Danese et al.   GASTROENTEROLOGY

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

(2014) Yael Haberman et al.   JOURNAL OF CLINICAL INVESTIGATION

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

(2014) Séverine Vermeire et al.   LANCET

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)

(2013) S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

(2011) Anne Christine W. Vos et al.   INFLAMMATORY BOWEL DISEASES

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation

(2010) Iurii Koboziev et al.   Annals of the New York Academy of Sciences

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES