Article
Biochemistry & Molecular Biology
Rodrigo Papa-Gobbi, Cecilia I. Muglia, Andres Rocca, Renata Curciarello, Alicia M. Sambuelli, Martin Yantorno, Gustavo Correa, Luciano G. Morosi, Antonio Di Sabatino, Paolo Biancheri, Thomas T. MacDonald, Marta A. Toscano, Karina V. Marino, Gabriel A. Rabinovich, Guillermo H. Docena
Summary: The study found that transient regulation of O-glycan profile during inflammation modulates Gal-1 binding and LP T-cell survival in IBD patients.
Article
Gastroenterology & Hepatology
Charles Caer, Frida Gorreja, Sophia K. Forsskahl, Siggeir F. Brynjolfsson, Louis Szeponik, Maria K. Magnusson, Lars G. Borjesson, Mattias Block, Elinor Bexe-Lindskog, Mary Jo Wick
Summary: The study showed that high expression of intestinal TREM-1 in IBD patients is associated with a high frequency of TREM-1(+) immature macrophages and TREM-1(+)CD11b(+) granulocytes, which contribute to the deleterious inflammatory microenvironment. Blocking the TREM-1 pathway, especially simultaneously with anti-TNF therapy, has potential as a new therapy for IBD.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Nutrition & Dietetics
Erik Oudman, Jan W. Wijnia, Misha J. Oey, Mirjam van Dam, Albert Postma
Summary: Crohn's disease and ulcerative colitis patients are at risk of developing Wernicke's encephalopathy due to thiamine depletion, rapid and high-dose thiamine treatment can effectively alleviate symptoms and save lives.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Sara Siskind, Max Brenner, Ping Wang
Summary: TREM-1, an upregulated pattern recognition receptor in inflammatory diseases, can amplify immune responses. The excessive activation of TREM-1 and increased levels of circulating sTREM-1 have been found to be associated with increased mortality in sepsis patients. Therefore, targeting TREM-1 could be a promising strategy for sepsis treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Nutrition & Dietetics
Marcela Guevara, Elena Salamanca-Fernandez, Estrella Miqueleiz, Diana Gavrila, Pilar Amiano, Catalina Bonet, Miguel Rodriguez-Barranco, Jose Maria Huerta, Luis Bujanda, Maria Jose Sanchez, Maria Dolores Chirlaque, Antonio Agudo, Eva Ardanaz, Jesus Castilla
Summary: Results suggest that consuming a more pro-inflammatory diet may contribute to the risk of Crohn's disease, while a healthy diet might be beneficial in its prevention. Further larger studies are needed to verify these findings.
Article
Immunology
Yaxing Zhao, Peng Liu, Yuanqiang Zhang, Hua Jiang, Haofan Luan, Yingmei Xu, Yubin Zhang, Ruiyan Li
Summary: This study found that Demethyleneberberine (DMB), a natural product from the rhizome of Coptis chinensis, possesses anti-inflammatory and immunoregulatory activities. It can alleviate ulcerative colitis (UC) and inhibit TLR4-mitochondria signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Maria K. Magnusson, Stefan Isaksson, Lena Ohman
Correction
Cell Biology
Berglind O. Einarsdottir, Joakim Karlsson, Elin M. V. Soderberg, Mattias F. Lindberg, Elisa Funck-Brentano, Henrik Jespersen, Siggeir F. Brynjolfsson, Roger Olofsson Bagge, Louise Carstam, Martin Scobie, Tobias Koolmeister, Olof Wallner, Ulrika Stierner, Ulrika Warpman Berglund, Lars Ny, Lisa M. Nilsson, Erik Larsson, Thomas Helleday, Jonas A. Nilsson
CELL DEATH & DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Yasaman Taslimi, Christopher Agbajogu, Siggeir Fannar Brynjolfsson, Nasrin Masoudzadeh, Vahid Mashayekhi, Safoora Gharibzadeh, Malin Ostensson, Sravya Sowdamini Nakka, Amir Mizbani, Sima Rafati, Ali M. Harandi
Article
Gastroenterology & Hepatology
Charles Caer, Frida Gorreja, Sophia K. Forsskahl, Siggeir F. Brynjolfsson, Louis Szeponik, Maria K. Magnusson, Lars G. Borjesson, Mattias Block, Elinor Bexe-Lindskog, Mary Jo Wick
Summary: The study showed that high expression of intestinal TREM-1 in IBD patients is associated with a high frequency of TREM-1(+) immature macrophages and TREM-1(+)CD11b(+) granulocytes, which contribute to the deleterious inflammatory microenvironment. Blocking the TREM-1 pathway, especially simultaneously with anti-TNF therapy, has potential as a new therapy for IBD.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Immunology
Inigo Perez-Heras, Christo Tsilifis, Mary A. Slatter, Siggeir F. Brynjolfsson, Asgeir Haraldsson, Andrew R. Gennery
Summary: Homozygous mutations in CYBC1 have been linked to CGD, with hematopoietic stem cell transplantation as the treatment choice, but experience in transplantation for this subtype of CGD is limited.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Siggeir F. Brynjolfsson, Hildur Sigurgrimsdottir, Elin D. Einarsdottir, Gudrun A. Bjornsdottir, Brynja Armannsdottir, Gudrun E. Baldvinsdottir, Agnar Bjarnason, Olafur Gudlaugsson, Sveinn Gudmundsson, Sigurveig T. Sigurdardottir, Arthur Love, Karl G. Kristinsson, Bjorn R. Ludviksson
Summary: Understanding the antibody response to SARS-CoV-2 is crucial, and a multiplex-based assay showed significant changes in different antibody types during different stages of the disease, emphasizing the importance of including IgA antibody detection in the analysis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Lujain Maasfeh, Anetta Hartlova, Stefan Isaksson, Johanna Sundin, Georgios Mavroudis, Otto Savolainen, Hans Strid, Lena Ohman, Maria K. Magnusson
Summary: Fecal luminal factors from healthy donors can down-regulate signaling pathways in macrophages and influence their function, while those from UC patients in remission have a weaker effect on macrophages. Metabolomic analysis revealed differential fecal metabolite composition between healthy individuals and UC patients in remission. This suggests that UC patients in remission may lack the necessary signals to condition macrophages towards a hyporesponsive and tolerogenic phenotype, making them vulnerable to relapse.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Siggeir F. Brynjolfsson, Hildur Sigurgrimsdottir, Olafur Gudlaugsson, Mar Kristjansson, Karl G. Kristinsson, Bjorn R. Ludviksson
Summary: This review discusses the contagiousness and immunity against SARS-CoV-2, and proposes guidelines for determining when COVID-19 patients reach a non-infectious state, based on clinical experience, scientific data, and proficient use of available tests.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Bani Ahluwalia, Maria K. Magnusson, Fredrik Larsson, Otto Savolainen, Alastair B. Ross, Lena Ohman
Summary: This study aimed to determine the metabolite composition of commercial Aloe extracts and assess their effects on human blood T cell activity. The results showed that different extracts had varying effects on T cells, including activation, proliferation, apoptosis, and cell death, which were related to the standard phytochemical composition of the extracts rather than the acemannan content.
Review
Immunology
Stefania P. Bjarnarson, Siggeir F. Brynjolfsson
Summary: The importance of antibodies, especially neutralizing antibodies, has been recognized for many years. Measuring the levels of antigen-specific antibodies is easier than measuring the T-cell response when examining immune responses to a pathogen after vaccination or infection, but it does not provide a complete picture. Determining the levels of neutralizing antibodies is more challenging, but it gives a better indication of the quality of the antibody response. Inducing long-lived antibody-secreting plasma cells is crucial for a persistent humoral immune response.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luiza Moraes Holst, Cristina Iribarren, Maria Sapnara, Otto Savolainen, Hans Tornblom, Yvonne Wettergren, Hans Strid, Magnus Simren, Maria K. Magnusson, Lena Ohman
Summary: This study analyzed the metabolite profiles of fecal supernatants from patients with colon cancer, ulcerative colitis, and irritable bowel syndrome, and investigated their effects on intestinal cells and colonoid cultures. The results showed that the fecal supernatants from different patient groups and healthy subjects altered the gene expression profiles of Caco-2 cells and colonoid cultures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Biographical-Item
Immunology
Mary Jo Wick, Ulf Yrlid
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Bani Ahluwalia, Maria K. Magnusson, Lena Bohn, Stine Storsrud, Fredrik Larsson, Lena Ohman, Magnus Simren
Summary: Aloe extract significantly improves symptom severity in IBS-D patients and increases the proportion of responders, but its effect on other IBS subtypes is not superior to control treatment.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)