Synthesis and studies of thiazolidinedione–isatin hybrids as α-glucosidase inhibitors for management of diabetes

Novel oxazolxanthone derivatives as a new type of α-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect

(2018) Sen-Miao Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, in vitro α-glucosidase inhibitory activity and docking studies of novel chromone-isatin derivatives

(2018) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and in vitro α-glucosidase inhibition of novel dihydropyrano[3,2-c]quinoline derivatives as potential anti-diabetic agents

(2018) Hamideh Nikookar et al.   BIOORGANIC CHEMISTRY

A new entry into the portfolio of α -glucosidase inhibitors as potent therapeutics for type 2 diabetes: Design, bioevaluation and one-pot multi-component synthesis of diamine-bridged coumarinyl oxadiazole conjugates

(2018) Madiha Kazmi et al.   BIOORGANIC CHEMISTRY

Synthesis of New Thiazolidine-2,-4-dione-azole Derivatives and Evaluation of Their α-Amylase and α-Glucosidase Inhibitory Activity

(2018) N. Senthilkumar et al.   Iranian Journal of Science and Technology Transaction A-Science

Synthesis of 1H-1,2,3-triazole derivatives as new α-glucosidase inhibitors and their molecular docking studies

(2018) Satya Kumar Avula et al.   BIOORGANIC CHEMISTRY

Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus

(2017) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α -Glucosidase inhibition by prenylated and lavandulyl compounds from Sophora flavescens roots and in silico analysis

(2017) Jang Hoon Kim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

New prospects for the development of selective inhibitors of α -glucosidase based on coumarin-iminothiazolidinone hybrids: Synthesis, in-vitro biological screening and molecular docking analysis

(2017) Aliya Ibrar et al.   Journal of the Taiwan Institute of Chemical Engineers

Novel indolyl linked para-substituted benzylidene-based phenyl containing thiazolidienediones and their analogs as α-glucosidase inhibitors: synthesis, in vitro, and molecular docking studies

(2017) Jeewanjot Kaur et al.   MEDICINAL CHEMISTRY RESEARCH

Evaluation the cytotoxic effect of cytotoxin-producing Klebsiella oxytoca isolates on the HEp-2 cell line by MTT assay

(2017) Mohammad Mehdi Soltan-Dallal et al.   MICROBIAL PATHOGENESIS

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors

(2017) et al.   MOLECULES

Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives

(2017) Zipeng Gong et al.   MOLECULES

Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives

(2017) Guang-cheng Wang et al.   MedChemComm

Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as α-glucosidase inhibitors

(2016) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Synthesis,in vitroevaluation and molecular docking studies of novel coumarin-isatin derivatives as α-glucosidase inhibitors

(2016) Guangcheng Wang et al.   Chemical Biology & Drug Design

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

(2016) Pramod K. Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors

(2015) Kailin Han et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies

(2015) Fazal Rahim et al.   BIOORGANIC CHEMISTRY

Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus

(2015) Zhi-Xu He et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Synthesis and evaluation of isatin-β-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species

(2015) Xu-Meng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel imino sugar α-glucosidase inhibitors as antiviral compounds

(2013) J.D. Howe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of Thiazolidine-2,4-Dione/Biphenylcarbonitrile Hybrid as Dual PPAR α/γ Modulator with Antidiabetic Effect:In vitro, In SilicoandIn VivoApproaches

(2013) Sergio Hidalgo-Figueroa et al.   Chemical Biology & Drug Design

Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

(2013) Yakaiah Chinthala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents

(2013) Nguyen-Hai Nam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents

(2012) Vasudeva Rao Avupati et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

α-1-C-Butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a Second-Generation Iminosugar-Based Oral α-Glucosidase Inhibitor for Improving Postprandial Hyperglycemia

(2012) Atsushi Kato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine Hybrids as Potential Antimalarial Agents

(2011) Sunny Manohar et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of novel dimethyl[1,1′-biphenyl]-2,2′-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice

(2011) Guangcheng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory potential of trilobatin from Lithocarpus polystachyus Rehd against α-glucosidase and α-amylase linked to type 2 diabetes

(2011) Hua-Qiang Dong et al.   FOOD CHEMISTRY

Molecular Dynamics Simulation and Free Energy Calculation Studies of the Binding Mechanism of Allosteric Inhibitors with p38α MAP Kinase

(2011) Ying Yang et al.   Journal of Chemical Information and Modeling

Novel 1,2,3-Triazole Derivatives for Use againstMycobacterium tuberculosisH37Rv (ATCC 27294) Strain

(2011) Nubia Boechat et al.   JOURNAL OF MEDICINAL CHEMISTRY

α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana

(2011) Hyung Won Ryu et al.   PHYTOCHEMISTRY

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards α-glucosidase

(2010) Rossana Pascale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways

(2010) Qianbin Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety

(2010) K.D. Thomas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant Anti-Inflammatory Treatment in Type 2 Diabetes

(2009) A. Ceriello et al.   DIABETES CARE

Discovery of (Z)-5-(4-Methoxybenzylidene)thiazolidine-2,4-dione, a Readily Available and Orally Active Glitazone for the Treatment of Concanavalin A-Induced Acute Liver Injury of BALB/c Mice

(2009) Youfu Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scavenging capacities of some thiazolyl thiazolidine-2,4-dione compounds on superoxide radical, hydroxyl radical, and DPPH radical

(2009) Irena Kruk et al.   LUMINESCENCE

Glycosidase inhibition: assessing mimicry of the transition state

(2009) Tracey M. Gloster et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing ‘click’ chemistry: DNA-binding affinity and anticancer activity

(2008) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

(2008) Zuping Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS

QMEAN: A comprehensive scoring function for model quality assessment

(2007) Pascal Benkert et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS