The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy

The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

(2020) William P. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress

(2020) Hugo Ramos et al.   Antioxidants

Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury

(2019) Zhonglong Liu et al.   Cell Death & Disease

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in retina

(2019) Sadie K. Dierschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation

(2019) Min Li et al.   Frontiers in Pharmacology

REDD1 knockdown protects H9c2 cells against myocardial ischemia/reperfusion injury through Akt/mTORC1/Nrf2 pathway-ameliorated oxidative stress: An in vitro study

(2019) Peng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE-19) cells

(2019) Arpitha Haranahalli Shivarudrappa et al.   Journal of Cell Communication and Signaling

Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

(2018) Florian A. Britto et al.   BMC BIOLOGY

Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation

(2018) Weiwei Dai et al.   FASEB JOURNAL

Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis

(2018) Xuhui Hou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina

(2018) Landon Rohowetz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Baicalin alleviates hyperglycemia-induced endothelial impairment via Nrf2

(2018) Gen Chen et al.   JOURNAL OF ENDOCRINOLOGY

Oxidative stress and diabetic retinopathy: development and treatment

(2017) G D Calderon et al.   EYE

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop

(2015) Ferdinando Giacco et al.   DIABETES

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

(2014) Manish Mishra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant Drug Therapy Approaches for Neuroprotection in Chronic Diseases of the Retina

(2014) Andrew Payne et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulated in Development and DNA Damage 1 Is Necessary for Hyperglycemia-induced Vascular Endothelial Growth Factor Expression in the Retina of Diabetic Rodents

(2014) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

(2014) M. D. Dennis et al.   Science Signaling

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets

(2014) Sher Zaman Safi et al.   Biomed Research International

Long-term Outcomes of Ranibizumab Therapy for Diabetic Macular Edema: The 36-Month Results from Two Phase III Trials

(2013) David M. Brown et al.   OPHTHALMOLOGY

Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?

(2012) Anthony J Adams et al.   Clinical and Experimental Optometry

Evaluation of the siRNA PF-04523655 versus Ranibizumab for the Treatment of Neovascular Age-related Macular Degeneration (MONET Study)

(2012) Quan Dong Nguyen et al.   OPHTHALMOLOGY

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Diabetic Retinopathy, Superoxide Damage and Antioxidants

(2011) Julia M. Santos et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine expression

(2011) Matthew G. Field et al.   EXPERIMENTAL EYE RESEARCH

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Effect of antioxidant N-acetylcysteine on diabetic retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic rats

(2011) Yuan Zhu et al.   MOLECULAR BIOLOGY REPORTS

Signaling of Reactive Oxygen and Nitrogen Species in Diabetes Mellitus

(2011) Igor Afanas'ev   Oxidative Medicine and Cellular Longevity

Differential Roles of Hyperglycemia and Hypoinsulinemia in Diabetes Induced Retinal Cell Death: Evidence for Retinal Insulin Resistance

(2011) Patrice E. Fort et al.   PLoS One

The Antioxidant Paradox in Diabetes Mellitus

(2010) Mae Sheikh-Ali et al.   AMERICAN JOURNAL OF THERAPEUTICS

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

(2010) Silvia Vega-Rubin-de-Celis et al.   BIOCHEMISTRY

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury

(2010) T. K. Ali et al.   DIABETOLOGIA

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress

(2009) Hyeon-Ok Jin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1

(2009) H.-R. Kim et al.   JOURNAL OF CELL SCIENCE

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Reactive Nitrogen Species: Molecular Mechanisms and Potential Significance in Health and Disease

(2008) M. Carmen Martínez et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT