Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rong Wang, Siwei Dong, Rui Xia, Meng Sun, Yi Sun, Hong Ren, Yonghui Zhang, Zhengyuan Xia, Shanglong Yao, Tingting Wang
Summary: This study investigates the protective effects of Kinsenoside (KD) in ischemia/reperfusion (I/R) injury and the underlying mechanism. KD attenuates myocardial injury in both vivo and in vitro models in a dose-dependent manner. The study suggests that KD exerts its antiferroptosis effect by mitigating mitochondrial dysfunction and enhancing anti-oxidation through the Akt/Nrf2/HO-1 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Shengyang Ding, Xinyu Duanmu, Lingshan Xu, Liang Zhu, Zhouquan Wu
Summary: Myocardial ischemia-reperfusion injury (MIRI) refers to the additional damage that occurs during the restoration of blood flow to the heart tissue after ischemic damage. Ozone therapy has been shown to reduce myocardial injury and protect against oxidative stress. In this study, ozone pretreatment was used in in vitro and in vivo models of ischemia-reperfusion injury, and it was found that ozone regulates the expression levels of ferroptosis-related proteins and transcription factors, leading to the protection of the myocardium. The Nrf2/Slc7a11/Gpx4 signaling pathway was identified as the mechanism responsible for the protective effects of ozone.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Chengliang Li, Jiajia Hao, Huichang Qiu, Hong Xin
Summary: This study found that up-regulation of CaMKK2 provides a therapeutic benefit in MI/R injury by enhancing the activation of the Nrf2 pathway through regulation of the AMPK/AKT/GSK-3β pathway. This suggests CaMKK2 as a new molecular target for the treatment of MI/R injury.
INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Xueheng Xie, Fan Wang, Wenxiu Ge, Xiangbao Meng, Lijuan Fan, Wei Zhang, Zhen Wang, Meng Ding, Shengliang Gu, Xiaoyan Xing, Xiaobo Sun
Summary: Scu exhibits antioxidant, anti-inflammatory, and neuroprotective effects in CIRI through Nrf2 activation mediated by the PI3K/Akt pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Critical Care Medicine
Zhenqian Lv, Feng'e Wang, Xingfeng Zhang, Xiting Zhang, Jing Zhang, Ran Liu
Summary: Etomidate (Eto) attenuated myocardial ischemia reperfusion injury (MIRI) by inhibiting ferroptosis via the Nrf2 pathway, demonstrating anti-inflammatory and anti-fibrotic effects in MIRI rats.
Article
Pharmacology & Pharmacy
Qianqian Zhang, Min Yao, Jiajia Qi, Rui Song, Lei Wang, Jiacheng Li, Xian Zhou, Dennis Chang, Qi Huang, Lili Li, Ning Wang
Summary: The natural compound Puerarin (PUE) has a therapeutic effect on cerebral ischemia-reperfusion injury by inhibiting oxidative stress related to the PI3K/Akt/Nrf2 pathway. Experimental results showed that PUE could improve neurological deficits in rats and reduce oxidative stress levels.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Qi Li, Zhuqing Li, Chunlei Liu, Mengping Xu, Tingting Li, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Xiaoyu Du, Chengzhi Lu
Summary: Maslinic acid derived from olive peel has anti-inflammatory and antioxidant properties. It reduces myocardial injury and oxidative stress by activating Nrf2/HO-1 pathway and inhibiting NF-κB activation.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hao Li, Yabin Chen, Mingjie Ding, Zhiping Yan, Wenzhi Guo, Ran Guo
Summary: Pretreatment with Pectolinarigenin (Pec) can reduce oxidative stress, inflammation, and cell apoptosis induced by hepatic ischemia/reperfusion (I/R) injury through activation of the PI3K/AKT/Nrf2 pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Xiaoxue Meng, Lu Zhang, Bing Han, Zheng Zhang
Summary: Studies have shown that PHLDA3 plays a crucial role in myocardial ischemia/reperfusion injury, and its inhibition can protect the myocardium from injury by regulating the Akt/GSK-3 beta/Nrf2 axis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chengxing Liu, Jin Zhou, Boyuan Wang, Yuqi Zheng, Shangwei Liu, Wenling Yang, Dazhu Li, Shaolin He, Jibin Lin
Summary: Bortezomib pretreatment mitigates myocardial ischemia reperfusion injury by inhibiting oxidative damage which is regulated by the Nrf2/HO-1 signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Integrative & Complementary Medicine
Youqiong Zhuo, Renyikun Yuan, Xinxin Chen, Jia He, Yangling Chen, Chenwei Zhang, Kaili Sun, Shilin Yang, Zhenjie Liu, Hongwei Gao
Summary: The study showed that Tanshinone I exerted cardiovascular protective effects both in vitro and in vivo by inhibiting RIP1/RIP3/MLKL and activating Akt/Nrf2 signaling pathways. It can alleviate oxidative stress, promote the expression of antioxidant-related proteins, and protect against myocardial ischemia-reperfusion injury.
Article
Pharmacology & Pharmacy
Min Zhang, Li Wei, Saiyang Xie, Yun Xing, Wenke Shi, Xiaofeng Zeng, Si Chen, Shasha Wang, Wei Deng, Qizhu Tang
Summary: Lithospermic acid (LA) pretreatment protects against myocardial ischemia-reperfusion injury by activating eNOS and Nrf2/HO-1 signaling, reducing infarct size and improving cardiac function.
LA ameliorates oxidative stress and cardiomyocyte apoptosis, playing a crucial role in heart function and pathology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Rui-ming Deng, Juan Zhou
Summary: Myocardial ischemia/reperfusion injury (MIRI) is a common and serious condition with no effective clinical treatments. The activation of the PI3K/Akt signaling pathway has been shown to have significant protective effects against MIRI through its involvement in antioxidant, anti-inflammatory, autophagy, mitochondrial function, and apoptosis regulation. This review highlights the molecular regulation of PI3K/Akt in MIRI, the effects of ischemic preconditioning and postconditioning, and the potential therapeutic applications of drugs targeting PI3K/Akt.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Sumei Liang, Juanping Han, Weiping Cheng, Xiaoan Chen
Summary: This study investigated the potential role and mechanism of CTRP6 in myocardial ischemia-reperfusion (I/R) injury through in vitro and in vivo experiments. CTRP6 expression was downregulated in hypoxia/reoxygenation (H/R)-treated cardiomyocytes. CTRP6 overexpression alleviated apoptosis, oxidative stress, and inflammation in H/R-treated cardiomyocytes, and ameliorated myocardial injury in mice with myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)