C-peptide prevents SMAD3 binding to alpha promoters to inhibit collagen type IV synthesis

The role of the complement system in diabetic nephropathy

(2017) Allan Flyvbjerg   Nature Reviews Nephrology

Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation

(2017) Meei-Ling Sheu et al.   Oncotarget

Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy

(2017) Ying Fan et al.   Scientific Reports

Parathyroid hormone inhibits TGF-β/Smad signaling and extracellular matrix proteins upregulation in rat mesangial cells

(2016) Fang-Fang Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High glucose decreases claudins-5 and -11 in cardiac microvascular endothelial cells: Antagonistic effects of tongxinluo

(2016) Bin Li et al.   ENDOCRINE RESEARCH

Synergistic effects of c-Jun and SP1 in the promotion of TGFβ1-mediated diabetic nephropathy progression

(2016) Pan Gao et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

PAPP-A in normal human mesangial cells: effect of inflammation and factors related to diabetic nephropathy

(2016) Diane Donegan et al.   JOURNAL OF ENDOCRINOLOGY

Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146

(2016) G. R. Kolar et al.   JOURNAL OF INTERNAL MEDICINE

C-peptide and the pathophysiology of microvascular complications of diabetes

(2016) J. Wahren   JOURNAL OF INTERNAL MEDICINE

C-peptide and diabetic kidney disease

(2016) N. J. Brunskill   JOURNAL OF INTERNAL MEDICINE

Combined treatment with vitamin E and gefitinib has synergistic effects to inhibit TGF-β1-induced renal fibroblast proliferation

(2016) GIOU-TENG YIANG et al.   Molecular Medicine Reports

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

(2016) Mitsuo Kato et al.   Nature Communications

Functional interaction between COL4A1/COL4A2 and SMAD3 risk loci for coronary artery disease

(2015) Adam W. Turner et al.   ATHEROSCLEROSIS

C-peptide ameliorates renal injury in type 2 diabetic rats through protein kinase A-mediated inhibition of fibronectin synthesis

(2015) Shiqing Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

C-peptide: New findings and therapeutic possibilities

(2015) John Wahren et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Developmental Stage-Specific Hepatocytes Induce Maturation of HepG2 Cells by Rebuilding the Regulatory Circuit

(2015) Yanning Li et al.   MOLECULAR MEDICINE

C-peptide modifies leptin and visfatin secretion in human adipose tissue

(2015) Sara Garcia-Serrano et al.   Obesity

C-peptide as a Therapy for Kidney Disease: A Systematic Review and Meta-Analysis

(2015) James A. Shaw et al.   PLoS One

Supramolecular Organization of the α121-α565 Collagen IV Network

(2014) Wesley E. Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic localization and functional implications of C-peptide might for suppression of iNOS in high glucose-stimulated rat mesangial cells

(2013) Yanning Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein nitration promotes inducible nitric oxide synthase transcription mediated by NF-κB in high glucose-stimulated human lens epithelial cells

(2013) Yanning Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Beneficial effects of C-peptide on renal morphology in diabetic rats

(2010) W. Sun et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

C-Peptide as a Therapeutic Tool in Diabetic Nephropathy

(2010) Claire E. Hills et al.   AMERICAN JOURNAL OF NEPHROLOGY

miR-192 Mediates TGF- /Smad3-Driven Renal Fibrosis

(2010) A. C. K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proinsulin C-Peptide Antagonizes the Profibrotic Effects of TGF-β1 via Up-Regulation of Retinoic Acid and HGF-Related Signaling Pathways

(2010) Claire E. Hills et al.   MOLECULAR ENDOCRINOLOGY

Proinsulin C-peptide Regulates Ribosomal RNA Expression

(2009) Emma Lindahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY