Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

(2020) Chieko Tashita et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

(2020) Bo Shen et al.   CELL

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery

(2020) N. J. Kapolka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task

(2020) David Phenis et al.   PSYCHOPHARMACOLOGY

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors

(2020) Mario Gennaro Mazza et al.   BRAIN BEHAVIOR AND IMMUNITY

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

(2020) Gayathri Sundaram et al.   Journal of Neuroinflammation

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Neurologic and neuroimaging findings in COVID-19 patients: A retrospective multicenter study

(2020) Stéphane Kremer et al.   NEUROLOGY

Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse

(2020) Luiz G. Gardinassi et al.   Frontiers in Immunology

Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19

(2020) Eve Garrigues et al.   JOURNAL OF INFECTION

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection

(2020) Torben Kimhofer et al.   JOURNAL OF PROTEOME RESEARCH

HCAR3: an underexplored metabolite sensor

(2020) Nicholas J. Kapolka et al.   NATURE REVIEWS DRUG DISCOVERY

Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress

(2020) George Anderson et al.   Biology-Basel

Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post–Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight

(2019) Louise A. Swainson et al.   JOURNAL OF IMMUNOLOGY

Relationships among neurotransmitters, cytokines and cognitive performance for individuals with hepatitis C achieving sustained virologic response: A pilot study

(2019) Ali A. Weinstein et al.   JOURNAL OF NEUROIMMUNOLOGY

Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood

(2018) Sarah M. Clark et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inhibition of kynurenine aminotransferase II attenuates hippocampus-dependent memory deficit in adult rats treated prenatally with kynurenine

(2018) Ana Pocivavsek et al.   HIPPOCAMPUS

Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice

(2017) Hisako Kubo et al.   IMMUNOLOGY LETTERS

Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

(2016) Paul B. Larkin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Quantitative metabolome profiling reveals the involvement of the kynurenine pathway in influenza-associated encephalopathy

(2016) Yuka Torii et al.   Metabolomics

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

(2016) Damian J Mole et al.   NATURE MEDICINE

Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients

(2015) S. Schulz et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

(2015) Leticia M. Toledo-Sherman et al.   JOURNAL OF MEDICINAL CHEMISTRY

The kynurenine pathway and neurodegenerative disease

(2015) Daniel C. Maddison et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition

(2014) Katerina Zavitsanou et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection

(2013) J. M. Fox et al.   JOURNAL OF GENERAL VIROLOGY

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats

(2011) Nady Braidy et al.   FEBS Journal

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine

(2011) Kathleen S. Alexander et al.   PSYCHOPHARMACOLOGY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis

(2009) J. Rodgers et al.   BRAIN

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH