Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post–Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight

Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation

(2018) Yuying Liu et al.   CANCER CELL

Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy

(2017) Sulggi Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Defining total-body AIDS-virus burden with implications for curative strategies

(2017) Jacob D Estes et al.   NATURE MEDICINE

Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions

(2017) Barbara Strasser et al.   NEUROPHARMACOLOGY

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease

(2016) Vahri Beaumont et al.   EXPERIMENTAL NEUROLOGY

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

(2016) Xavier Dagenais-Lussier et al.   JOURNAL OF VIROLOGY

Gut epithelial barrier and systemic inflammation during chronic HIV infection

(2015) Ma Somsouk et al.   AIDS

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

(2015) Leticia M. Toledo-Sherman et al.   JOURNAL OF MEDICINAL CHEMISTRY

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

(2015) Marie Favennec et al.   Obesity

Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge

(2015) Chris A. R. Baker et al.   Science Translational Medicine

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

(2015) Ivan Vujkovic-Cvijin et al.   Cell Reports

Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques

(2014) J. D. Estes et al.   JOURNAL OF IMMUNOLOGY

PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination

(2014) A. C. Finnefrock et al.   JOURNAL OF IMMUNOLOGY

The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy

(2014) H. Byakwaga et al.   JOURNAL OF INFECTIOUS DISEASES

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection

(2014) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

New Insights into IDO Biology in Bacterial and Viral Infections

(2014) Susanne V. Schmidt et al.   Frontiers in Immunology

Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands

(2013) Geoffrey L. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In Vivo Blockade of the Programmed Cell Death-1 Pathway Using Soluble Recombinant PD-1-Fc Enhances CD4+ and CD8+ T Cell Responses but Has Limited Clinical Benefit

(2013) P. K. Amancha et al.   JOURNAL OF IMMUNOLOGY

Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection

(2013) G. Breton et al.   JOURNAL OF IMMUNOLOGY

Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

(2013) Mohammad-Ali Jenabian et al.   PLoS One

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

(2013) Edward Seung et al.   PLoS One

Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease

(2012) Mathuravani A. Thevandavakkam et al.   CNS & Neurological Disorders-Drug Targets

In Vivo Blockade of the PD-1 Receptor Suppresses HIV-1 Viral Loads and Improves CD4+ T Cell Levels in Humanized Mice

(2012) B. E. Palmer et al.   JOURNAL OF IMMUNOLOGY

Reduced Inflammation and Lymphoid Tissue Immunopathology in Rhesus Macaques Receiving Anti–Tumor Necrosis Factor Treatment During Primary Simian Immunodeficiency Virus Infection

(2012) Brian Tabb et al.   JOURNAL OF INFECTIOUS DISEASES

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

(2011) J. Godin-Ethier et al.   CLINICAL CANCER RESEARCH

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Th17, gut, and HIV: therapeutic implications

(2010) Peter W Hunt   Current Opinion in HIV and AIDS

Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells

(2009) D. J. Chung et al.   BLOOD

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

(2008) Thomas J. Connor et al.   NEUROSCIENCE LETTERS