Neuronal migration and disorders – an update

Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly

(2020) Meng-Han Tsai et al.   NEURON

Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5

(2020) Andrew Kodani et al.   NEURON

ECE 2 regulates neurogenesis and neuronal migration during human cortical development

(2020) Isabel Y Buchsbaum et al.   EMBO REPORTS

Molecular mechanisms of cell polarity in a range of model systems and in migrating neurons

(2020) Yves Jossin   MOLECULAR AND CELLULAR NEUROSCIENCE

Centrosome anchoring regulates progenitor properties and cortical formation

(2020) Wei Shao et al.   NATURE

How the extracellular matrix shapes neural development

(2019) Katherine R. Long et al.   Open Biology

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

(2019) Johannes Klaus et al.   NATURE MEDICINE

The centrosome protein AKNA regulates neurogenesis via microtubule organization

(2019) Germán Camargo Ortega et al.   NATURE

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

(2019) L. Telley et al.   SCIENCE

Malformations of Human Neocortex in Development – Their Progenitor Cell Basis and Experimental Model Systems

(2019) Anneline Pinson et al.   Frontiers in Cellular Neuroscience

TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis

(2019) Ekaterina L. Ivanova et al.   Nature Communications

Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells

(2019) Maxime Penisson et al.   Frontiers in Cellular Neuroscience

Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia

(2019) Ana Uzquiano et al.   Cell Reports

TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex

(2019) Xiaohui Lv et al.   Nature Communications

Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

(2019) Lena Will et al.   Acta Neuropathologica Communications

Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny

(2019) Johan G Gilet et al.   HUMAN MOLECULAR GENETICS

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis

(2018) Carla G. Silva et al.   CELL

Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1

(2018) Stefanie Brock et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Tubulin genes and malformations of cortical development

(2018) Romina Romaniello et al.   European Journal of Medical Genetics

Cortical progenitor biology: key features mediating proliferation versus differentiation

(2018) Ana Uzquiano et al.   JOURNAL OF NEUROCHEMISTRY

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

(2018) Stefania Tavano et al.   NEURON

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

(2018) Sang Min Park et al.   NEURON

Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy

(2018) Daniel T. Pederick et al.   NEURON

Genetics and mechanisms leading to human cortical malformations

(2018) Delfina M. Romero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex

(2018) Adam C. O’Neill et al.   Frontiers in Cellular Neuroscience

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice

(2018) I-Ling Lu et al.   Nature Communications

De novo and inherited private variants in MAP1B in periventricular nodular heterotopia

(2018) Erin L. Heinzen et al.   PLoS Genetics

Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex

(2018) Katherine R. Long et al.   NEURON

Extensive branching of radially-migrating neurons in the mammalian cerebral cortex

(2018) Maria Á. Martínez-Martínez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Primate-Specific Isoform of PLEKHG6 Regulates Neurogenesis and Neuronal Migration

(2018) Adam C. O’Neill et al.   Cell Reports

Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading

(2017) Jianjun Hu et al.   HUMAN MOLECULAR GENETICS

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration

(2017) Richard Belvindrah et al.   JOURNAL OF CELL BIOLOGY

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex

(2017) Sara Bizzotto et al.   Scientific Reports

Biallelic Mutations in TBCD , Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy

(2016) Elisabetta Flex et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling

(2016) Jimit Shah et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exome Sequencing Identifies De Novo DYNC1H1 Mutations Associated With Distal Spinal Muscular Atrophy and Malformations of Cortical Development

(2016) Yulin Chen et al.   JOURNAL OF CHILD NEUROLOGY

Mutations in the HECT domain of NEDD4L lead to AKT–mTOR pathway deregulation and cause periventricular nodular heterotopia

(2016) Loïc Broix et al.   NATURE GENETICS

Microtubule-associated protein 1b is required for shaping the neural tube

(2016) Pradeepa Jayachandran et al.   Neural Development

Neuronal migration disorders: Focus on the cytoskeleton and epilepsy

(2016) Melissa A. Stouffer et al.   NEUROBIOLOGY OF DISEASE

Recurrent de novo BICD2 mutation associated with arthrogryposis multiplex congenita and bilateral perisylvian polymicrogyria

(2016) Gianina Ravenscroft et al.   NEUROMUSCULAR DISORDERS

Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development

(2015) C. Badouel et al.   DEVELOPMENT

Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia

(2015) Gewei Lian et al.   Frontiers in Cellular Neuroscience

Mutations of CEP83 Cause Infantile Nephronophthisis and Intellectual Disability

(2014) Marion Failler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

The wide spectrum of tubulinopathies: what are the key features for the diagnosis?

(2014) Nadia Bahi-Buisson et al.   BRAIN

Role of radial glial cells in cerebral cortex folding

(2014) Víctor Borrell et al.   CURRENT OPINION IN NEUROBIOLOGY

Malformations of cortical development: clinical features and genetic causes

(2014) Renzo Guerrini et al.   LANCET NEUROLOGY

Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human

(2014) Michel Kielar et al.   NATURE NEUROSCIENCE

Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

(2014) B.-I. Bae et al.   SCIENCE

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

A developmental and genetic classification for malformations of cortical development: update 2012

(2012) A. James Barkovich et al.   BRAIN

A Radial Glia-Specific Role of RhoA in Double Cortex Formation

(2012) Silvia Cappello et al.   NEURON

MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

(2010) Carolina Montenegro-Venegas et al.   MOLECULAR BIOLOGY OF THE CELL

Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

(2009) Takashi Ishiuchi et al.   JOURNAL OF CELL BIOLOGY