The Lymph Node Reservoir: Physiology, HIV Infection, and Antiretroviral Therapy

Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

(2020) Louise Leyre et al.   Science Translational Medicine

An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes

(2020) Aditya Jagarapu et al.   Frontiers in Bioengineering and Biotechnology

Characterization of intact proviruses in blood and lymph node from HIV-infected individuals undergoing analytical treatment interruption

(2019) Line K. Vibholm et al.   JOURNAL OF VIROLOGY

Infectious virus persists in CD4+ T cells and macrophages in ART-suppressed SIV-infected Macaques

(2019) Celina M. Abreu et al.   JOURNAL OF VIROLOGY

Antiretroviral drug concentrations in lymph nodes: a cross-species comparison of the effect of drug transporter expression, viral infection, and sex in humanized mice, nonhuman primates, and humans

(2019) Erin Burgunder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy

(2019) Rachel L. Miller et al.   JOURNAL OF VIROLOGY

Spatial distribution of elvitegravir and tenofovir in rat brain tissue: Application of MALDI-MSI and LC-MS/MS

(2019) Sphamandla Ntshangase et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species

(2019) Corbin G. Thompson et al.   Science Translational Medicine

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

(2019) Nadine Bachmann et al.   Nature Communications

Quantification of the Whole Lymph Node Vasculature Based on Tomography of the Vessel Corrosion Casts

(2019) M. Jafarnejad et al.   Scientific Reports

Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs

(2019) Sphamandla Ntshangase et al.   ACS Omega

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Multimorbidity, age-related comorbidities and mortality

(2018) Pierre Duffau et al.   AIDS

Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy

(2018) Yu Gao et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection

(2018) Lisa A. McConnachie et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Three HIV drugs, atazanavir, ritonavir and tenofovir co-formulated in drug-combination nanoparticles exhibit long-acting and lymphocyte targeting properties in non-human primates

(2018) Simone Perazzolo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species

(2018) Nithya Srinivas et al.   XENOBIOTICA

Proliferation of latently infected CD4+T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

(2017) Nina N. Hosmane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus–Infected Individuals Receiving Suppressive Antiretroviral Therapy

(2017) Gabriela Khoury et al.   JOURNAL OF INFECTIOUS DISEASES

Defining total-body AIDS-virus burden with implications for curative strategies

(2017) Jacob D Estes et al.   NATURE MEDICINE

The Lymph Node in HIV Pathogenesis

(2017) Yiannis Dimopoulos et al.   Current HIV/AIDS Reports

Ongoing HIV Replication During ART Reconsidered

(2017) Mary F Kearney et al.   Open Forum Infectious Diseases

Treatment interruption in chronically HIV-infected patients with an ultralow HIV reservoir

(2016) Ruxandra Calin et al.   AIDS

Infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging analysis of biospecimens

(2016) M. T. Bokhart et al.   ANALYST

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer

(2016) Rebecca Rose et al.   JOURNAL OF VIROLOGY

HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

(2016) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

Nanodrug formulations to enhance HIV drug exposure in lymphoid tissues and cells: clinical significance and potential impact on treatment and eradication of HIV/AIDS

(2016) Jingwei Shao et al.   Nanomedicine

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Clonally expanded CD4+T cells can produce infectious HIV-1 in vivo

(2016) Francesco R. Simonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue reservoirs of HIV

(2016) Joseph K. Wong et al.   Current Opinion in HIV and AIDS

Current status and prospects of HIV treatment

(2016) Tomas Cihlar et al.   Current Opinion in Virology

Anti-HIV Drug-Combination Nanoparticles Enhance Plasma Drug Exposure Duration as Well as Triple-Drug Combination Levels in Cells Within Lymph Nodes and Blood in Primates

(2015) Jennifer P. Freeling et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Understanding HIV Latency: The Road to an HIV Cure

(2015) Matthew S. Dahabieh et al.   Annual Review of Medicine

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

(2015) Corbin G. Thompson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

(2015) Mohammad Jafarnejad et al.   Lymphatic Research and Biology

Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping

(2015) Raf Van de Plas et al.   NATURE METHODS

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Lymphatic system: An active pathway for immune protection

(2015) Shan Liao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A rapid spin through oil results in higher cell-associated concentrations of antiretrovirals compared with conventional cell washing

(2015) Theodore J Cory et al.   Bioanalysis

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

(2015) Mohammad Jafarnejad et al.   Lymphatic Research and Biology

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization

(2014) Mark T. Bokhart et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies

(2014) Benson Edagwa et al.   CURRENT MEDICINAL CHEMISTRY

IR-MALDESI Mass Spectrometry Imaging of Biological Tissue Sections Using Ice as a Matrix

(2014) Guillaume Robichaud et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mapping Antiretroviral Drugs in Tissue by IR-MALDESI MSI Coupled to the Q Exactive and Comparison with LC-MS/MS SRM Assay

(2014) Jeremy A. Barry et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues

(2013) Jacob D. Estes   IMMUNOLOGICAL REVIEWS

Persistence of Viral Reservoirs in Multiple Tissues after Antiretroviral Therapy Suppression in a Macaque RT-SHIV Model

(2013) Christopher Kline et al.   PLoS One

In situ metabolomic mass spectrometry imaging: Recent advances and difficulties

(2012) Daisuke Miura et al.   Journal of Proteomics

Mass spectrometry imaging for drug distribution studies

(2012) Brendan Prideaux et al.   Journal of Proteomics

Lymphoid tissue structure and HIV-1 infection: life or death for T cells

(2012) Ming Zeng et al.   TRENDS IN IMMUNOLOGY

Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population

(2011) G. Guaraldi et al.   CLINICAL INFECTIOUS DISEASES

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV Latency in the Humanized BLT Mouse

(2011) M. D. Marsden et al.   JOURNAL OF VIROLOGY

Acute HIV-1 Infection

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy

(2011) Mariko Horiike et al.   VIROLOGY

Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART

(2011) Maria J. Buzón et al.   PLoS Pathogens

Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion

(2010) Olivier Bourry et al.   Retrovirology

Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS

(2009) T. W. North et al.   JOURNAL OF VIROLOGY

In Situ Lymph Dynamic Characterization through Lymph Nodes in Rabbit Hind Leg: Special Reference to Nodal Inflammation

(2008) Takashi Nagai et al.   Journal of Physiological Sciences

The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

(2008) Jacob D. Estes et al.   SEMINARS IN IMMUNOLOGY

PEGylated Elastic Liposomal Formulation for Lymphatic Targeting of Zidovudine

(2008) Subheet Jain et al.   Current Drug Delivery