A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

Cristae undergo continuous cycles of membrane remodelling in a MICOS ‐dependent manner

(2020) Arun Kumar Kondadi et al.   EMBO REPORTS

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

(2020) Till Stephan et al.   EMBO JOURNAL

Myristoyl group-aided protein import into the mitochondrial intermembrane space

(2019) Eri Ueda et al.   Scientific Reports

Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact

(2019) Junhui Tang et al.   CELL DEATH AND DIFFERENTIATION

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis

(2019) Eduardo Balsa et al.   MOLECULAR CELL

Crosstalk between phosphorylation and O-GlcNAcylation: friend or foe

(2018) Saar A. M. van der Laarse et al.   FEBS Journal

The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization

(2018) Peng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

(2018) Sandra Backes et al.   JOURNAL OF CELL BIOLOGY

Supra-pharmacological concentration of capsaicin stimulates brown adipogenesis through induction of endoplasmic reticulum stress

(2018) Ryosuke Kida et al.   Scientific Reports

Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice

(2017) Naresh C. Bal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

(2017) Lawrence Kazak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases

(2017) Pierre Theurey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

(2017) Martín Alcalá et al.   Scientific Reports

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

(2016) Shiori Akabane et al.   MOLECULAR CELL

Mitochondrial CHCHD-Containing Proteins: Physiologic Functions and Link with Neurodegenerative Diseases

(2016) Zhi-Dong Zhou et al.   MOLECULAR NEUROBIOLOGY

How the glycosyltransferase OGT catalyzes amide bond cleavage

(2016) John Janetzko et al.   Nature Chemical Biology

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

(2016) Francesca Sacco et al.   Nature Communications

Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue

(2016) Zhenjiang Liu et al.   Oncotarget

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization

(2015) H Li et al.   CELL DEATH AND DIFFERENTIATION

Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure

(2015) Kosaku Shinoda et al.   Cell Metabolism

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

(2015) Paul Cohen et al.   DIABETES

In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis

(2015) Sébastien M. Labbé et al.   FASEB JOURNAL

The Oxidation Status of Mic19 Regulates MICOS Assembly

(2015) Paulina Sakowska et al.   MOLECULAR AND CELLULAR BIOLOGY

Detailed Analysis of the Human Mitochondrial Contact Site Complex Indicate a Hierarchy of Subunits

(2015) Christine Ott et al.   PLoS One

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

(2014) Stéphan Hardivillé et al.   Cell Metabolism

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

Cross-talk between Two Essential Nutrient-sensitive Enzymes

(2014) John W. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

A Quantitative Map of the Liver Mitochondrial Phosphoproteome Reveals Posttranslational Control of Ketogenesis

(2012) Paul A. Grimsrud et al.   Cell Metabolism

Targeting and Import Mechanism of Coiled-coil Helix Coiled-coil Helix Domain-containing Protein 3 (ChChd3) into the Mitochondrial Intermembrane Space

(2012) Manjula Darshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of CHCHD5 and CHCHD7: Two atypical human twin CX9C proteins

(2012) Lucia Banci et al.   JOURNAL OF STRUCTURAL BIOLOGY

Global Identification and Characterization of BothO-GlcNAcylation and Phosphorylation at the Murine Synapse

(2012) Jonathan C. Trinidad et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis

(2012) Mary Katherine Tarrant et al.   Nature Chemical Biology

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

The structure of the PERK kinase domain suggests the mechanism for its activation

(2011) Wenjun Cui et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Regulation of Mitochondrial Protein Import by Cytosolic Kinases

(2011) Oliver Schmidt et al.   CELL

Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70in VitroSuggests a Chaperone Displacement Mechanism

(2011) Anna C. Y. Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Function of Cytosolic Chaperones in Tom70-Mediated Mitochondrial Import

(2011) Anna C.Y. Fan et al.   PROTEIN AND PEPTIDE LETTERS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Uncoupling protein-1 is not leaky

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

(2010) Manjula Darshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Tom70 in Import of Presequence-containing Mitochondrial Proteins

(2009) Hayashi Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Regulation of theO-Linked β-N-Acetylglucosamine Transferase by Insulin Signaling

(2008) Stephen A. Whelan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY