Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma

TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

(2020) Qingyu Luo et al.   Cell Reports

Predictive and prognostic value of ZEB1 protein expression in breast cancer patients with neoadjuvant chemotherapy

(2019) Ziping Wu et al.   Cancer Cell International

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

(2019) Jinhuan Wu et al.   CANCER LETTERS

Overexpression of TRIM26 suppresses the proliferation, metastasis, and glycolysis in papillary thyroid carcinoma cells

(2019) Kefeng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation

(2019) Kaikai Ding et al.   ONCOGENE

miR-1271 inhibits growth, invasion and epithelial–mesenchymal transition by targeting ZEB1 in ovarian cancer cells

(2019) Yanni Jiao et al.   OncoTargets and Therapy

Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma

(2019) Xiaolan Zhang et al.   Cell Death & Disease

UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma

(2019) Li-Li Liu et al.   Cancer Management and Research

Ubiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT

(2019) Congcong Yan et al.   MEDICAL ONCOLOGY

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

(2019) Roxsan Manshouri et al.   Nature Communications

Post-transcription mediated Snail stabilization is involved in radiation exposure induced invasion and migration of hepatocarcinoma cells

(2018) Liyang Dong et al.   BIOMEDICINE & PHARMACOTHERAPY

A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification

(2018) Sarah Nicklas et al.   CELL DEATH AND DIFFERENTIATION

TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14

(2018) Liang Chen et al.   Nature Communications

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response

(2018) Xiao-Ming Lyu et al.   Cancer Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation

(2017) H Zhou et al.   ONCOGENE

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

(2017) Deguan Lv et al.   Nature Communications

Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response

(2016) Matthew J. Edmonds et al.   NUCLEIC ACIDS RESEARCH

Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma

(2016) Yuan Zhao et al.   TUMOR BIOLOGY

TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis

(2015) Yi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

USP39 promotes the growth of human hepatocellular carcinoma in vitro and in vivo

(2015) XIANWEN YUAN et al.   ONCOLOGY REPORTS

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

(2015) Yong Ran et al.   Journal of Molecular Cell Biology

Tumour suppressor TRIM33 targets nuclear β-catenin degradation

(2015) Jianfei Xue et al.   Nature Communications

Identification of enzymes involved in SUMOylation in Trypanosoma brucei

(2015) Kaiqin Ye et al.   Scientific Reports

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

(2015) Peng Wang et al.   PLoS Pathogens

Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma

(2012) Jiaxing Zhang et al.   MOLECULAR BIOLOGY REPORTS

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of Aurora B

(2011) Renske J. van Leuken et al.   CELL CYCLE

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

(2011) Mark P A Luna-Vargas et al.   EMBO REPORTS

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

Selective Accumulation of Aggregation-Prone Proteasome Substrates in Response to Proteotoxic Stress

(2009) F. A. Salomons et al.   MOLECULAR AND CELLULAR BIOLOGY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY