The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

Sox4 cooperates with CREB in myeloid transformation

(2012) S. Sandoval et al.   BLOOD

Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma

(2012) Chandramu Chetty et al.   CANCER LETTERS

SOX4 Induces Epithelial-Mesenchymal Transition and Contributes to Breast Cancer Progression

(2012) J. Zhang et al.   CANCER RESEARCH

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Clinicopathological significance of SOX4 expression in primary gallbladder carcinoma

(2012) Chengguo Wang et al.   Diagnostic Pathology

GPR56 in cancer progression: current status and future perspective

(2012) Liquan Yang et al.   Future Oncology

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas

(2012) Makoto Saegusa et al.   LABORATORY INVESTIGATION

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells

(2012) Suling Liu et al.   PLoS Genetics

The crystal structure of the Sox4 HMG domain–DNA complex suggests a mechanism for positional interdependence in DNA recognition

(2011) Ralf Jauch et al.   BIOCHEMICAL JOURNAL

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia

(2011) G. Aue et al.   BLOOD

SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells

(2011) Yu-Heng Lai et al.   BMC CELL BIOLOGY

Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias

(2011) B. T. Kvinlaug et al.   CANCER RESEARCH

Novel Transcriptional Targets of the SRY-HMG Box Transcription Factor SOX4 Link Its Expression to the Development of Small Cell Lung Cancer

(2011) S. D. Castillo et al.   CANCER RESEARCH

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm

(2011) C. Tian et al.   DEVELOPMENT

Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport

(2011) J. Kindla et al.   DRUG METABOLISM AND DISPOSITION

Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 Protein

(2011) Hiroaki Ikushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype

(2011) Rune Jemtland et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TRB3 interacts with SMAD3 promoting tumor cell migration and invasion

(2011) F. Hua et al.   JOURNAL OF CELL SCIENCE

Class-C SOX Transcription Factors ControlGnRHGene Expression via the Intronic Transcriptional Enhancer

(2011) Hee-Dae Kim et al.   MOLECULAR ENDOCRINOLOGY

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

SOX4 expression levels in urothelial bladder carcinoma

(2011) Sezgin Gunes et al.   PATHOLOGY RESEARCH AND PRACTICE

Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk

(2011) Emma L. Duncan et al.   PLoS Genetics

Prognostic Significance of Sox4 Expression in Human Cutaneous Melanoma and Its Role in Cell Migration and Invasion

(2010) Seyed Mehdi Jafarnejad et al.   AMERICAN JOURNAL OF PATHOLOGY

Leukemia stem cells

(2010) Ugo Testa   ANNALS OF HEMATOLOGY

Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer

(2010) Ruizhe Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia

(2010) J. Bies et al.   BLOOD

SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro

(2010) Wonhee Hur et al.   CARCINOGENESIS

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Epigenetic Priming of a Pre-B Cell-Specific Enhancer through Binding of Sox2 and Foxd3 at the ESC Stage

(2010) Daniel Liber et al.   Cell Stem Cell

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Sox11 regulates survival and axonal growth of embryonic sensory neurons

(2010) L. Lin et al.   DEVELOPMENTAL DYNAMICS

Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis

(2010) Amanda R. Ritter et al.   DEVELOPMENTAL DYNAMICS

Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes

(2010) Toshiaki Watanabe et al.   EUROPEAN JOURNAL OF CANCER

CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4

(2010) Mohd S. Iqbal et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

(2010) Tony Blick et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development

(2010) Daniela C. Thein et al.   JOURNAL OF NEUROCHEMISTRY

POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature

(2010) J M Fortier et al.   LEUKEMIA

Massively Parallel Signature Sequencing and Bioinformatics Analysis Identifies Up-Regulation of TGFBI and SOX4 in Human Glioblastoma

(2010) Biaoyang Lin et al.   PLoS One

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma

(2010) S. Molatore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors

(2010) Pallavi Bhattaram et al.   Nature Communications

The Sex-Determining Region Y-Box 4 and Homeobox C6 Transcriptional Networks in Prostate Cancer Progression

(2009) Carlos S. Moreno   AMERICAN JOURNAL OF PATHOLOGY

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output

(2009) J. M. Beekman et al.   BLOOD

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer

(2009) C L Andersen et al.   BRITISH JOURNAL OF CANCER

Genome-Wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells

(2009) C. D. Scharer et al.   CANCER RESEARCH

Epigenetic Repression of microRNA-129-2 Leads to Overexpression of SOX4 Oncogene in Endometrial Cancer

(2009) Y.-W. Huang et al.   CANCER RESEARCH

Genomic Profiling of MicroRNAs in Bladder Cancer: miR-129 Is Associated with Poor Outcome and Promotes Cell Death In vitro

(2009) L. Dyrskjot et al.   CANCER RESEARCH

A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity

(2009) Eric Deneault et al.   CELL

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer†

(2009) Pedro P. Medina et al.   HUMAN MOLECULAR GENETICS

Twenty Sox, twenty years

(2009) Vincent Harley et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acquisition of SOX transcription factor specificity through protein–protein interaction, modulation of Wnt signalling and post-translational modification

(2009) Pascal Bernard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of SOX4 by DNA damage is critical for p53 stabilization and function

(2009) X. Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

(2009) A. Ragvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

(2008) Markus Heidenblad et al.   BMC Medical Genomics

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

(2008) Dan D. Hershko   CANCER

mda-9/Syntenin: More than Just a Simple Adapter Protein When It Comes to Cancer Metastasis

(2008) D. Sarkar et al.   CANCER RESEARCH

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

(2008) M. Goldsworthy et al.   DIABETES

The ins and outs of syntenin, a multifunctional intracellular adaptor protein

(2008) J. M. Beekman et al.   JOURNAL OF CELL SCIENCE

Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors

(2008) M. Hoser et al.   MOLECULAR AND CELLULAR BIOLOGY

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties

(2008) Peter Dy et al.   NUCLEIC ACIDS RESEARCH

Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma

(2008) Y-L Liao et al.   ONCOGENE

Gene expression profile of mouse prostate tumors reveals dysregulations in major biological processes and identifies potential murine targets for preclinical development of human prostate cancer therapy

(2008) Kerstyn M. Haram et al.   PROSTATE

Using global gene expression patterns to characterize Annexin V positive and negative human monocytes in culture

(2008) Per Kr. Lund et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION