Unidirectional intercellular communication on a microfluidic chip

Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array

(2020) Raphaël F.-X. Tomasi et al.   Cell Reports

The role of tumor-stroma interactions on desmoplasia and tumorigenicity within a microengineered 3D platform

(2020) Harpinder Saini et al.   BIOMATERIALS

A flyover style microfluidic chip for highly purified magnetic cell separation

(2019) Shujing Lin et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

(2019) Peng Zhang et al.   Nature Biomedical Engineering

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

(2019) Danh D Truong et al.   CANCER RESEARCH

A microfluidic chip enables isolation of exosomes and establishment of their protein profiles and associated signaling pathways in ovarian cancer

(2019) Kalpana Deepa Priya Dorayappan et al.   CANCER RESEARCH

Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling

(2019) Jiaquan Yu et al.   Nature Biomedical Engineering

Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

(2019) Shujing Lin et al.   Small

In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids

(2019) Yesl Jun et al.   Science Advances

Droplet Array-Based 3D Coculture System for High-Throughput Tumor Angiogenesis Assay

(2018) Xiaohui Du et al.   ANALYTICAL CHEMISTRY

Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling

(2018) Cassandra Ringuette Goulet et al.   MOLECULAR CANCER RESEARCH

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid

(2018) Sang Woo Lee et al.   Scientific Reports

Exosome Research and Co-culture Study

(2018) Takeo Shimasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A three-dimensional (3D) organotypic microfluidic model for glioma stem cells – Vascular interactions

(2018) Danh Truong et al.   BIOMATERIALS

Bioengineering strategies to accelerate stem cell therapeutics

(2018) Christopher M. Madl et al.   NATURE

Notch signaling in regulating angiogenesis in a 3D biomimetic environment

(2017) Yi Zheng et al.   LAB ON A CHIP

Bridging the gap: microfluidic devices for short and long distance cell–cell communication

(2017) Timothy Quang Vu et al.   LAB ON A CHIP

Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions

(2017) Thomas J. Moutinho et al.   PLoS One

Mesenchymal Stem Cells Induce Epithelial to Mesenchymal Transition in Colon Cancer Cells through Direct Cell-to-Cell Contact

(2017) Hidehiko Takigawa et al.   NEOPLASIA

A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche

(2017) Hacer Ezgi Karakas et al.   Scientific Reports

A novel mast cell co-culture microfluidic chip for the electrochemical evaluation of food allergen

(2016) Hui Jiang et al.   BIOSENSORS & BIOELECTRONICS

Single cell dual adherent-suspension co-culture micro-environment for studying tumor–stromal interactions with functionally selected cancer stem-like cells

(2016) Yu-Chih Chen et al.   LAB ON A CHIP

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

(2016) Yufang Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

Acquisition of new tumor cell properties by MSC-derived exosomes

(2015) YUANYUAN YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication

(2015) Luis F. Alonzo et al.   LAB ON A CHIP

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

(2015) Ridwana Chowdhury et al.   Oncotarget

Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids

(2015) Hongxu Lu et al.   Biomaterials Science

Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal

(2014) Yu-Chih Chen et al.   LAB ON A CHIP

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Studying cell-cell communication in co-culture

(2013) Danielle R. Bogdanowicz et al.   Biotechnology Journal

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer

(2012) A. K. Mitra et al.   Cancer Discovery

Fluorescent magnetic nanoparticle-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of in vivo gastric cancer

(2012) Jing Ruan et al.   Nanoscale Research Letters

Microdroplet-Enabled Highly Parallel Co-Cultivation of Microbial Communities

(2011) Jihyang Park et al.   PLoS One

Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α

(2009) Javier Guerrero et al.   BREAST CANCER RESEARCH AND TREATMENT

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

(2009) Masayuki Shimoda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging

(2009) Shannon Kidd et al.   STEM CELLS

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP