Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers

Pembrolizumab for Early Triple-Negative Breast Cancer

(2020) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells

(2020) Gamal-Eldein Fathy Abd-Ellatef et al.   Pharmaceutics

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

(2020) Joanna Kopecka et al.   Cells

Advances in the systemic treatment of triple-negative breast cancer

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Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

(2018) Iris C. Salaroglio et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

P-Glycoprotein Inhibition Sensitizes Human Breast Cancer Cells to Proteasome Inhibitors

(2017) Rahul R. Deshmukh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Establishment and characterization of a triple negative basal-like breast cancer cell line with multi-drug resistance

(2017) Sergei Boichuk et al.   Oncology Letters

Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells

(2016) Li-han Zhang et al.   APOPTOSIS

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)

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Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

(2016) Nicole Seebacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure–Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance

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A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

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The role of ABC transporters in ovarian cancer progression and chemoresistance

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Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

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Diversity in ABC transporters: Type I, II and III importers

(2014) Austin J. Rice et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development

(2014) Young Choi et al.   CURRENT PHARMACEUTICAL DESIGN

Pluronics and MDR Reversal: An Update

(2014) Daria Y. Alakhova et al.   MOLECULAR PHARMACEUTICS

The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity

(2014) Gábor Szalóki et al.   PLoS One

“Drug resistance associated membrane proteins”

(2014) Katy S. Sherlach et al.   Frontiers in Physiology

Triple-Negative Breast Cancer and the Need for New Therapeutic Targets

(2013) Olav Engebraaten et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes

(2013) H. Masuda et al.   CLINICAL CANCER RESEARCH

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neoadjuvant Chemotherapy Induces Expression Levels of Breast Cancer Resistance Protein That Predict Disease-Free Survival in Breast Cancer

(2013) Baek Kim et al.   PLoS One

Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance

(2012) K. G. Chen et al.   CLINICAL CANCER RESEARCH

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance

(2012) Roel H. Wilting et al.   DRUG RESISTANCE UPDATES

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

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Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes

(2011) Niravkumar R. Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine

(2009) J. Abraham et al.   CLINICAL CANCER RESEARCH

Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus

(2008) Masashi Tsuchida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An overview of cancer multidrug resistance: a still unsolved problem

(2008) H. Lage   CELLULAR AND MOLECULAR LIFE SCIENCES

Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

(2008) Cornelia Liedtke et al.   JOURNAL OF CLINICAL ONCOLOGY

Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration

(2008) B Chapuy et al.   LEUKEMIA

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

(2008) S. Rottenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant ABC proteins – a unified nomenclature and updated inventory

(2008) Paul J. Verrier et al.   TRENDS IN PLANT SCIENCE