Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

Characterizing the efficacy of cancer therapeutics in patient-derived xenograft models of metastatic breast cancer

(2018) Tia H. Turner et al.   BREAST CANCER RESEARCH AND TREATMENT

The role of nitric oxide in metabolic regulation of Dendritic cell immune function

(2018) Phyu M. Thwe et al.   CANCER LETTERS

Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer

(2018) Daniel Dávila-González et al.   CLINICAL CANCER RESEARCH

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma

(2018) Joanna Kopecka et al.   LUNG CANCER

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

(2018) Bo Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pegylated liposomal formulation of doxorubicin overcomes drug resistance in a genetically engineered mouse model of breast cancer

(2017) András Füredi et al.   JOURNAL OF CONTROLLED RELEASE

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition

(2017) Saikat Dewanjee et al.   MOLECULES

Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance

(2017) Konstantin Chegaev et al.   ACS Medicinal Chemistry Letters

Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer

(2017) Guilhem Bousquet et al.   Oncotarget

Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways

(2017) Pablo Garrido et al.   Oncotarget

Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein

(2015) Chiara Riganti et al.   CANCER LETTERS

The Role of C/EBP-β LIP in Multidrug Resistance

(2015) Chiara Riganti et al.   JNCI-Journal of the National Cancer Institute

Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers

(2015) Hasitha Shilpa Anantaraju et al.   MOLECULAR DIVERSITY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

The Role of C/EBP-β LIP in Multidrug Resistance

(2015) Chiara Riganti et al.   JNCI-Journal of the National Cancer Institute

Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics

(2015) Benjamin Bonavida et al.   Redox Biology

Co-formulation of P-glycoprotein Substrate and Inhibitor in Nanocarriers: An Emerging Strategy for Cancer Chemotherapy

(2014) Ankit Saneja et al.   CURRENT CANCER DRUG TARGETS

Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells

(2014) Xiaofei Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine

(2014) Charlotte E. Johnson et al.   Molecular Oncology

Liposomal Nitrooxy-Doxorubicin: One Step over Caelyx in Drug-Resistant Human Cancer Cells

(2014) Isabella Pedrini et al.   MOLECULAR PHARMACEUTICS

Inhibition of neutral sphingomyelinase decreases elevated levels of inducible nitric oxide synthase and apoptotic cell death in ocular hypertensive rats

(2014) Mutay Aslan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition

(2013) Joanna Kopecka et al.   Nanomedicine-Nanotechnology Biology and Medicine

Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

(2013) Chiara Riganti et al.   PLoS One

FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial

(2012) S. Ladoire et al.   ANNALS OF ONCOLOGY

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

(2012) Sophie Doublier et al.   BMC CANCER

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors

(2012) Simmy Thomas et al.   CANCER LETTERS

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

In situ immune response after neoadjuvant chemotherapy for breast cancer predicts survival

(2011) Sylvain Ladoire et al.   JOURNAL OF PATHOLOGY

The prognostic importance of cathepsin D and E-cadherin in early breast cancer: A single-institution experience

(2011) GALIA JACOBSON-RABER et al.   Oncology Letters

Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells

(2010) Joanna Kopecka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular Symbiosis of CHOP and C/EBP  Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced Apoptosis

(2010) C.-B. Chiribau et al.   MOLECULAR AND CELLULAR BIOLOGY

C/EBP-β Regulates Endoplasmic Reticulum Stress–Triggered Cell Death in Mouse and Human Models

(2010) Ofir Meir et al.   PLoS One

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells

(2009) Sara De Boo et al.   Molecular Cancer

Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death

(2008) Philip Y. Lam et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

RhoA Silencing Reverts the Resistance to Doxorubicin in Human Colon Cancer Cells

(2008) S. Doublier et al.   MOLECULAR CANCER RESEARCH

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress

(2007) Chiara Riganti et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY