Novel Schiff base-bridged multi-component sulfonamide imidazole hybrids as potentially highly selective DNA-targeting membrane active repressors against methicillin-resistant Staphylococcus aureus

Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles

(2020) Yan-Fei Sui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators

(2020) Yuan-Yuan Hu et al.   Future Medicinal Chemistry

Sulfonamide-derived Four-component Molecular Hybrids as Novel DNA-targeting Membrane Active Potentiators against Clinical Escherichia coli

(2019) Yuan-Yuan Hu et al.   MOLECULAR PHARMACEUTICS

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

(2019) Nicholas A. Turner et al.   NATURE REVIEWS MICROBIOLOGY

Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus

(2019) Chun-Fang Hu et al.   BIOORGANIC CHEMISTRY

A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus

(2019) Zhen-Zhen Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove

(2018) Ya-Nan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Azoalkyl ether imidazo[2,1- b ]benzothiazoles as potentially antimicrobial agents with novel structural skeleton

(2018) Swetha Kameswari Maddili et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological evaluation and computational studies of novel iminothiazolidinone benzenesulfonamides as potent carbonic anhydrase II and IX inhibitors

(2018) Shams-ul Mahmood et al.   BIOORGANIC CHEMISTRY

Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation

(2018) Han-Bo Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii

(2018) Wei-Wei Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi

(2018) Yuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel naphthalimide nitroimidazoles as multitargeting antibacterial agents against resistant Acinetobacter baumannii

(2018) Jie Kang et al.   Future Medicinal Chemistry

C8-Linked Pyrrolobenzodiazepine Monomers with Inverted Building Blocks Show Selective Activity against Multidrug Resistant Gram-Positive Bacteria

(2018) Paolo Andriollo et al.   ACS Infectious Diseases

A new class of synthetic retinoid antibiotics effective against bacterial persisters

(2018) Wooseong Kim et al.   NATURE

Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant Staphylococcus aureus

(2018) Di Li et al.   MedChemComm

Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues

(2017) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 2,4- thiazolidinediones: Synthesis, in vitro cytotoxic activity, and mechanistic investigation

(2017) Kamel Metwally et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)

(2017) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

Design, synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents

(2017) Wei-Wei Gao et al.   Science China-Chemistry

Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli

(2017) Guo-Biao Zhang et al.   Science China-Chemistry

Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents

(2017) Jun-Rong Duan et al.   MedChemComm

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents

(2017) Ying-Ying Chen et al.   ACS Medicinal Chemistry Letters

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

(2017) Jonathan M. Stokes et al.   Nature Microbiology

Synthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents

(2016) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells

(2016) Yu Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism

(2016) Sheng-Feng Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies for target identification of antimicrobial natural products

(2016) Maya A. Farha et al.   NATURAL PRODUCT REPORTS

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Coumarin-derived azolyl ethanols: synthesis, antimicrobial evaluation and preliminary action mechanism

(2016) Xin-Mei Peng et al.   Science China-Chemistry

Synthesis and biological evaluation of Schiff base-linked imidazolyl naphthalimides as novel potential anti-MRSA agents

(2016) Huo-Hui Gong et al.   MedChemComm

Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury

(2015) Keisuke Ito et al.   Acta Biomaterialia

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Synthesis of novel sulfonamide azoles via C–N cleavage of sulfonamides by azole ring and relational antimicrobial study

(2015) Hui-Zhen Zhang et al.   NEW JOURNAL OF CHEMISTRY

Synthesis and bioactive evaluation of a novel series of coumarinazoles

(2014) Guri L.V. Damu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Current Developments of Coumarin Compounds in Medicinal Chemistry

(2013) Xin-Mei Peng et al.   CURRENT PHARMACEUTICAL DESIGN

Recent Developments in Azole Compounds as Antibacterial and Antifungal Agents

(2013) Xin-Mei Peng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

(2013) Ling Zhang et al.   MEDICINAL RESEARCH REVIEWS

Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs

(2013) H. Haruki et al.   SCIENCE

Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-ResistantStaphylococcus aureus

(2012) Tyler L. Harris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Ab Initio Design of Potent Anti-MRSA Peptides Based on Database Filtering Technology

(2012) Biswajit Mishra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents

(2011) Xiao-Fang Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of the riddle of sulfathiazole polymorphism

(2011) Mohd R. Abu Bakar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis and Biological Evaluation of Novel Thiazolidinedione Analogues as 15-Hydroxyprostaglandin Dehydrogenase Inhibitors

(2011) Ying Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-AIDS agents 82: Synthesis of seco-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents

(2010) Jian Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents

(2010) Yuan Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones

(2009) Tihomir Tomašić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY