Mitochondrial reactive zones in antiviral innate immunity

Influenza Virus-Induced Oxidized DNA Activates Inflammasomes

(2020) Miyu Moriyama et al.   iScience

Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity

(2020) Johannes Burtscher et al.   iScience

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases

(2019) Mafalda Escobar-Henriques et al.   Frontiers in Physiology

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity

(2019) Kai Yasukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

(2019) Miyu Moriyama et al.   Nature Communications

NLRP3-associated autoinflammatory diseases: Phenotypic and molecular characteristics of germline versus somatic mutations

(2019) Camille Louvrier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Mitochondria in innate immune signaling

(2018) Balaji Banoth et al.   Translational Research

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

(2018) Rachael Barry et al.   Nature Communications

The Cellular Mitochondrial Genome Landscape in Disease

(2018) Anne Hahn et al.   TRENDS IN CELL BIOLOGY

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

(2017) Takuma Yoshizumi et al.   Scientific Reports

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

(2016) Laurent Chatel-Chaix et al.   Cell Host & Microbe

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

CLPB Variants Associated with Autosomal-Recessive Mitochondrial Disorder with Cataract, Neutropenia, Epilepsy, and Methylglutaconic Aciduria

(2015) Carol Saunders et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

(2015) Harshad Ingle et al.   Science Signaling

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins

(2015) Chia-Yi Yu et al.   PLoS Pathogens

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

(2015) Harshad Ingle et al.   Science Signaling

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

(2014) S R Kim et al.   Cell Death & Disease

Primate-specific miR-576-3p sets host defense signalling threshold

(2014) Melanie L. Yarbrough et al.   Nature Communications

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

(2014) Takuma Yoshizumi et al.   Nature Communications

A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer

(2013) Osamu Sasaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Mitochondrial-derived N-formyl peptides: Novel links between trauma, vascular collapse and sepsis

(2013) C.F. Wenceslau et al.   MEDICAL HYPOTHESES

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

(2013) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial-mediated antiviral immunity

(2012) Takumi Koshiba   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

MicroRNAs in the regulation of TLR and RIG-I pathways

(2012) Yingke Li et al.   Cellular & Molecular Immunology

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Mitochondria and cell signalling

(2012) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Mitochondria in innate immunity

(2011) Damien Arnoult et al.   EMBO REPORTS

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

(2011) T. Koshiba et al.   Science Signaling

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Recognition of viruses by cytoplasmic sensors

(2010) Courtney Wilkins et al.   CURRENT OPINION IN IMMUNOLOGY

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

(2010) C. Wei et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

(2010) Kazuhide Onoguchi et al.   PLoS Pathogens

Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS

(2009) Damien Vitour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

(2009) J. Hou et al.   JOURNAL OF IMMUNOLOGY

MAVS Self-Association Mediates Antiviral Innate Immune Signaling

(2009) E. D. Tang et al.   JOURNAL OF VIROLOGY

Mitochondrial Antiviral Signaling Protein Plays a Major Role in Induction of the Fish Innate Immune Response against RNA and DNA Viruses

(2009) S. Biacchesi et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling

(2009) C. T. Cornillez-Ty et al.   JOURNAL OF VIROLOGY

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

(2009) L. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

(2009) K. Yasukawa et al.   Science Signaling

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES