MicroRNAs in the regulation of TLR and RIG-I pathways

MicroRNA-155 Silencing Enhances Inflammatory Response and Lipid Uptake in Oxidized Low-Density Lipoprotein-Stimulated Human THP-1 Macrophages

(2016) Ri-sheng Huang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway

(2014) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2

(2012) Zhongwen Wu et al.   FEBS LETTERS

microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-κB1 in murine macrophages

(2012) Jianni Qi et al.   FEBS LETTERS

Control of Cytokine mRNA Expression by RNA-binding Proteins and microRNAs

(2012) V. Palanisamy et al.   JOURNAL OF DENTAL RESEARCH

Integrin CD11b Negatively Regulates TLR9-Triggered Dendritic Cell Cross-Priming by Upregulating microRNA-146a

(2012) Y. Bai et al.   JOURNAL OF IMMUNOLOGY

Downregulation of PCAF by miR-181a/b Provides Feedback Regulation to TNF- -Induced Transcription of Proinflammatory Genes in Liver Epithelial Cells

(2012) J. Zhao et al.   JOURNAL OF IMMUNOLOGY

Identification of Resting and Type I IFN-Activated Human NK Cell miRNomes Reveals MicroRNA-378 and MicroRNA-30e as Negative Regulators of NK Cell Cytotoxicity

(2012) P. Wang et al.   JOURNAL OF IMMUNOLOGY

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

(2012) Hayato Takahashi et al.   NATURE IMMUNOLOGY

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps–SHP-2 pathway

(2012) Sheng Xu et al.   NATURE IMMUNOLOGY

Dissecting negative regulation of Toll-like receptor signaling

(2012) Takeshi Kondo et al.   TRENDS IN IMMUNOLOGY

Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality

(2011) Y. Sun et al.   BLOOD

MicroRNA in TLR signaling and endotoxin tolerance

(2011) Md A Nahid et al.   Cellular & Molecular Immunology

MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4

(2011) Ke Yang et al.   FEBS LETTERS

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

RIG-I-like receptors: cytoplasmic sensors for non-self RNA

(2011) Hiroki Kato et al.   IMMUNOLOGICAL REVIEWS

Polymicrobial Infection with Periodontal Pathogens Specifically Enhances MicroRNA miR-146a in ApoE−/−Mice during Experimental Periodontal Disease

(2011) Md A. Nahid et al.   INFECTION AND IMMUNITY

Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response

(2011) Hongliang Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-365, a Novel Negative Regulator of Interleukin-6 Gene Expression, Is Cooperatively Regulated by Sp1 and NF-κB

(2011) Zheng Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

(2011) Mingjin Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CMRF-35-Like Molecule 3 Preferentially Promotes TLR9-Triggered Proinflammatory Cytokine Production in Macrophages by Enhancing TNF Receptor-Associated Factor 6 Ubiquitination

(2011) Y. Wu et al.   JOURNAL OF IMMUNOLOGY

TLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes

(2011) L. Philippe et al.   JOURNAL OF IMMUNOLOGY

Both miR-17-5p and miR-20a Alleviate Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating STAT3 Expression

(2011) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-  Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity

(2011) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

(2011) Aikaterini S Papadopoulou et al.   NATURE IMMUNOLOGY

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

(2011) Sungchul Kim et al.   NATURE IMMUNOLOGY

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b

(2011) Riccardo L Rossi et al.   NATURE IMMUNOLOGY

The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ

(2011) Feng Ma et al.   NATURE IMMUNOLOGY

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

Identification of MyD88 as a novel target of miR-155, involved in negative regulation ofHelicobacter pylori-induced inflammation

(2010) Bin Tang et al.   FEBS LETTERS

MicroRNAs Distinguish Translational from Transcriptional Silencing during Endotoxin Tolerance

(2010) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-27b Contributes to Lipopolysaccharide-mediated Peroxisome Proliferator-activated Receptor γ (PPARγ) mRNA Destabilization

(2010) Carla Jennewein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-10 Inhibits miR-155 Induction by Toll-like Receptors

(2010) Claire E. McCoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flanking region sequence information to refine microRNA target predictions

(2010) Russiachand Heikham et al.   JOURNAL OF BIOSCIENCES

Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1

(2010) P. Wang et al.   JOURNAL OF IMMUNOLOGY

miR-146a Is Differentially Expressed by Myeloid Dendritic Cell Subsets and Desensitizes Cells to TLR2-Dependent Activation

(2010) J. Jurkin et al.   JOURNAL OF IMMUNOLOGY

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

(2010) Joan Ní Gabhann et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-148/152 Impair Innate Response and Antigen Presentation of TLR-Triggered Dendritic Cells by Targeting CaMKII 

(2010) X. Liu et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-466l Upregulates IL-10 Expression in TLR-Triggered Macrophages by Antagonizing RNA-Binding Protein Tristetraprolin-Mediated IL-10 mRNA Degradation

(2010) F. Ma et al.   JOURNAL OF IMMUNOLOGY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator

(2010) Dimitrios Lagos et al.   NATURE CELL BIOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation

(2010) Tao Li et al.   NATURE IMMUNOLOGY

The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination

(2010) Daphna Nachmani et al.   NATURE IMMUNOLOGY

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells

(2010) Rui Zhou et al.   NUCLEIC ACIDS RESEARCH

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

The interplay between transcription factors and microRNAs in genome-scale regulatory networks

(2009) Natalia J. Martinez et al.   BIOESSAYS

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

(2009) Ariadne Androulidaki et al.   IMMUNITY

MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase

(2009) Iftach Shaked et al.   IMMUNITY

Modulation of TLR2 Protein Expression by miR-105 in Human Oral Keratinocytes

(2009) Manjunatha R. Benakanakere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late Endosome/Lysosome-Localized Rab7b Suppresses TLR9-Initiated Proinflammatory Cytokine and Type I IFN Production in Macrophages

(2009) M. Yao et al.   JOURNAL OF IMMUNOLOGY

Bruton's Tyrosine Kinase Is Involved in miR-346-Related Regulation of IL-18 Release by Lipopolysaccharide-Activated Rheumatoid Fibroblast-Like Synoviocytes

(2009) G. Alsaleh et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

(2009) J. Hou et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge

(2009) G. Hu et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression

(2009) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

(2009) Chen Wang et al.   NATURE IMMUNOLOGY

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF

(2009) Jesper Worm et al.   NUCLEIC ACIDS RESEARCH

MiR-155 Induction by F. novicida but Not the Virulent F. tularensis Results in SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response

(2009) Thomas J. Cremer et al.   PLoS One

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells

(2009) Maurizio Ceppi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses

(2009) G. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol phosphatase SHIP1 is a primary target of miR-155

(2009) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a

(2009) A. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

(2009) F. Bazzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-kappaB p65-Dependent Transactivation of miRNA Genes following Cryptosporidium parvum Infection Stimulates Epithelial Cell Immune Responses

(2009) Rui Zhou et al.   PLoS Pathogens

The roles of microRNAs in mammalian virus infection

(2008) R GRASSMANN et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

(2008) X. Liu et al.   BLOOD

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages

(2008) Hongmei Xu et al.   MOLECULAR IMMUNOLOGY

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

MicroRNAs: new regulators of immune cell development and function

(2008) David Baltimore et al.   NATURE IMMUNOLOGY

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency

(2008) E. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA