Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma

Review Article: Epithelial cell function and remodeling in nasal polyposis

(2020) Lora G. Bankova et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2

(2020) Saltanat Ualiyeva et al.   Science Immunology

Our evolving understanding of the pathogenesis and presentations of chronic rhinosinusitis

(2020) William Eschenbacher et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides

(2020) Alexander Perniss et al.   IMMUNITY

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity

(2020) Ursula Smole et al.   NATURE IMMUNOLOGY

Acetylcholine From Tuft Cells: The Updated Insights Beyond Its Immune and Chemosensory Functions

(2020) Jun Pan et al.   Frontiers in Cell and Developmental Biology

Denatonium benzoate bitter taste perception in chronic rhinosinusitis subgroups

(2020) Alyssa M. Civantos et al.   International Forum of Allergy & Rhinology

Development of solitary chemosensory cells in the distal lung after severe influenza injury

(2019) Chetan K Rane et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Associations between inflammatory endotypes and clinical presentations in chronic rhinosinusitis

(2019) Whitney W. Stevens et al.   Journal of Allergy and Clinical Immunology-In Practice

Expression of Bitter Taste Receptors and Solitary Chemosensory Cell Markers in the Human Sinonasal Cavity

(2019) Jingguo Chen et al.   CHEMICAL SENSES

Biologics for the treatment of chronic rhinosinusitis with nasal polyps - state of the art

(2019) Lei Ren et al.   World Allergy Organization Journal

Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch

(2019) Youcef Ouadah et al.   CELL

“Tuft Cells”: A New Player in Hirschsprung's Disease

(2019) Anne Marie O'Donnell et al.   EUROPEAN JOURNAL OF PEDIATRIC SURGERY

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

(2019) Antonia Wallrapp et al.   IMMUNITY

Taste Receptors in Upper Airway Innate Immunity

(2019) Ryan M. Carey et al.   Nutrients

Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists

(2019) Stanislas Grassin-Delyle et al.   Frontiers in Physiology

Role of Group 2 Innate Lymphocytes in Aspirin-exacerbated Respiratory Disease Pathogenesis

(2018) Andrew A. White et al.   American Journal of Rhinology & Allergy

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

(2018) Yu-Han Huang et al.   GENES & DEVELOPMENT

Identifying a missing lineage driver in a subset of lung neuroendocrine tumors

(2018) Karine Pozo et al.   GENES & DEVELOPMENT

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Endotype-driven care pathways in patients with chronic rhinosinusitis

(2018) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps

(2018) Michael A. Kohanski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary neuroendocrine cells amplify allergic asthma responses

(2018) Pengfei Sui et al.   SCIENCE

Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps

(2018) Neil N. Patel et al.   International Forum of Allergy & Rhinology

Biomarkers in Chronic Rhinosinusitis with Nasal Polyps

(2018) Alan D. Workman et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

A New Spin on Mast Cells and Cysteinyl Leukotrienes: Leukotriene E4 Activates Mast Cells in vivo

(2018) Lora G. Bankova et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Aspirin-Exacerbated Respiratory Disease

(2018) Andrew A. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

(2018) Naoteru Miyata et al.   Cell Reports

Pulmonary Neuroendocrine Cells Secrete GABA to Induce Goblet Cell Hyperplasia in Primate Models

(2018) Juliana Barrios et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tuft Cells—Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry

(2018) Claire E. O'Leary et al.   Annual Review of Immunology

Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes

(2018) Hoai T. T. Tran et al.   Frontiers in Immunology

Acetylcholine signaling system in progression of lung cancers

(2018) Jamie R. Friedman et al.   PHARMACOLOGY & THERAPEUTICS

Doublecortin and CaM kinase-like-1 expression in pathological stage I non-small cell lung cancer

(2017) Hiroyuki Tao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Association of interleukin-25 levels with development of aspirin induced respiratory diseases

(2017) Jong-Uk Lee et al.   RESPIRATORY MEDICINE

Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes

(2017) Ryan M. Carey et al.   International Forum of Allergy & Rhinology

Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis

(2016) Whitney W. Stevens et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Leukotriene E4elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99

(2016) Lora G. Bankova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells

(2016) Matthias Martin Gaida et al.   Pathogens and Disease

Fevipiprant, a prostaglandin D 2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial

(2016) Sherif Gonem et al.   Lancet Respiratory Medicine

Interleukin-25 and Interleukin-33 as Mediators of Eosinophilic Inflammation in Chronic Rhinosinusitis

(2015) Matthew Lam et al.   American Journal of Rhinology & Allergy

Cost of adult chronic rhinosinusitis: A systematic review

(2015) Kristine A. Smith et al.   LARYNGOSCOPE

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

(2015) E D Tait Wojno et al.   Mucosal Immunology

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

TAS2R38genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis

(2015) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

Doublecortin-Like Kinase 1 Is Elevated Serologically in Pancreatic Ductal Adenocarcinoma and Widely Expressed on Circulating Tumor Cells

(2015) Dongfeng Qu et al.   PLoS One

Assessment of Trends in Antimicrobial Resistance in Chronic Rhinosinusitis

(2014) Neil Bhattacharyya et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Non-neuronal cholinergic airway epithelium biology

(2014) Wolfgang Kummer et al.   CURRENT OPINION IN PHARMACOLOGY

Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells

(2014) Hiroyuki Mutoh et al.   Gut and Liver

CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

(2014) Ye Chun Ruan et al.   JOURNAL OF CELL SCIENCE

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

(2014) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells

(2014) N. A. Barrett et al.   JOURNAL OF IMMUNOLOGY

Treatment of canine asthma by high selective vagotomy

(2014) Rui Liu et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation

(2014) C. J. Saunders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemosensory Brush Cells of the Trachea. A Stable Population in a Dynamic Epithelium

(2013) Cecil J. Saunders et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention

(2013) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery

(2013) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

(2012) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma

(2012) M. Suzukawa et al.   JOURNAL OF IMMUNOLOGY

Taste receptor signalling - from tongues to lungs

(2011) S. C. Kinnamon   Acta Physiologica

DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism

(2011) S. M. Sureban et al.   CANCER RESEARCH

Gastric tuft cells express DCLK1 and are expanded in hyperplasia

(2011) Milena Saqui-Salces et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cholinergic chemosensory cells in the trachea regulate breathing

(2011) G. Krasteva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Location, Location, Location: Compartmentalization of Early Events in Leukotriene Biosynthesis

(2010) Marcia E. Newcomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals

(2010) M. Tizzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DCAMKL-1 Expression Identifies Tuft Cells Rather Than Stem Cells in the Adult Mouse Intestinal Epithelium

(2009) François Gerbe et al.   GASTROENTEROLOGY

The leukotriene E4 puzzle: Finding the missing pieces and revealing the pathobiologic implications

(2009) K. Frank Austen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells

(2008) C. Bezençon et al.   JOURNAL OF COMPARATIVE NEUROLOGY