rAAV-Mediated Human FGF-2 Gene Therapy Enhances Osteochondral Repair in a Clinically Relevant Large Animal Model Over Time In Vivo

Autologous Chondrocyte Implantation as Treatment for Unsalvageable Osteochondritis Dissecans: 10- to 25-Year Follow-up

(2020) James L. Carey et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Small-Diameter Subchondral Drilling Improves DNA and Proteoglycan Content of the Cartilaginous Repair Tissue in a Large Animal Model of a Full-Thickness Chondral Defect

(2020) Patrick Orth et al.   Journal of Clinical Medicine

Targeted delivery of FGF2 to subchondral bone enhanced the repair of articular cartilage defect

(2018) Wenyu Yang et al.   Acta Biomaterialia

Effects of TGF-β Overexpression via rAAV Gene Transfer on the Early Repair Processes in an Osteochondral Defect Model in Minipigs

(2018) Magali Cucchiarini et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Sustained spatiotemporal release of TGF-β1 confers enhanced very early chondrogenic differentiation during osteochondral repair in specific topographic patterns

(2018) Ann-Kathrin Asen et al.   FASEB JOURNAL

Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair

(2018) Magali Cucchiarini et al.   Nature Reviews Rheumatology

Multi-layered PLLA-nanosheets loaded with FGF-2 induce robust bone regeneration with controlled release in critical-sized mouse femoral defects

(2018) Yasutaka Murahashi et al.   Acta Biomaterialia

Brief Report: Partial- and Full-Thickness Focal Cartilage Defects Contribute Equally to Development of New Cartilage Damage in Knee Osteoarthritis: The Multicenter Osteoarthritis Study

(2017) Ali Guermazi et al.   Arthritis & Rheumatology

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

(2016) Ke Tao et al.   Stem Cell Research & Therapy

Cartilage Restoration of the Knee

(2015) Raman Mundi et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Small-Diameter Awls Improve Articular Cartilage Repair After Microfracture Treatment in a Translational Animal Model

(2015) Patrick Orth et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Gene therapy approaches to regenerating the musculoskeletal system

(2015) Christopher H. Evans et al.   Nature Reviews Rheumatology

Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation

(2015) D. Correa et al.   OSTEOARTHRITIS AND CARTILAGE

Small Subchondral Drill Holes Improve Marrow Stimulation of Articular Cartilage Defects

(2014) Mona Eldracher et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

(2014) M Cucchiarini et al.   GENE THERAPY

Chondrogenic Differentiation of Mesenchymal Stem Cells: Challenges and Unfulfilled Expectations

(2014) Rodrigo A. Somoza et al.   TISSUE ENGINEERING PART B-REVIEWS

A low morbidity surgical approach to the sheep femoral trochlea

(2013) Patrick Orth et al.   BMC MUSCULOSKELETAL DISORDERS

Improved repair of chondral and osteochondral defects in the ovine trochlea compared with the medial condyle

(2013) Patrick Orth et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Exogenous bFGF promotes articular cartilage repair via up-regulation of multiple growth factors

(2013) X. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo

(2013) P. Orth et al.   OSTEOARTHRITIS AND CARTILAGE

Reduction of Sample Size Requirements by Bilateral Versus Unilateral Research Designs in Animal Models for Cartilage Tissue Engineering

(2013) Patrick Orth et al.   TISSUE ENGINEERING PART C-METHODS

Effect of Subchondral Drilling on the Microarchitecture of Subchondral Bone

(2012) Patrick Orth et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis

(2012) Tiffany Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

(2012) Magali Cucchiarini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T – comparative evaluation of five macroscopic scoring systems in a large animal cartilage defect model

(2012) L. Goebel et al.   OSTEOARTHRITIS AND CARTILAGE

The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model

(2011) Roberta Tasso et al.   BIOMATERIALS

Basic fibroblast growth factor supports expansion of mouse compact bone-derived mesenchymal stem cells (MSCs) and regeneration of bone from MSC in vivo

(2011) Eiki Yamachika et al.   JOURNAL OF MOLECULAR HISTOLOGY

Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

(2011) M.I. Menendez et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolic Activities and Chondrogenic Differentiation of Human Mesenchymal Stem Cells Following Recombinant Adeno-Associated Virus–Mediated Gene Transfer and Overexpression of Fibroblast Growth Factor 2

(2011) Magali Cucchiarini et al.   TISSUE ENGINEERING PART A

Collagen Three-Dimensional Hydrogel Matrix Carrying Basic Fibroblast Growth Factor for the Cultivation of Mesenchymal Stem Cells and Osteogenic Differentiation

(2011) Sun-Ae Oh et al.   TISSUE ENGINEERING PART A

Reliability, Reproducibility, and Validation of Five Major Histological Scoring Systems for Experimental Articular Cartilage Repair in the Rabbit Model

(2011) Patrick Orth et al.   TISSUE ENGINEERING PART C-METHODS

Gene Therapy for Cartilage Repair

(2011) Henning Madry et al.   Cartilage

Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model

(2009) Xuan Guo et al.   Acta Biomaterialia

Repair of large osteochondral defects in rabbits using porous hydroxyapatite/collagen (HAp/Col) and fibroblast growth factor-2 (FGF-2)

(2009) Hidetsugu Maehara et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Animal Models for Cartilage Regeneration and Repair

(2009) Constance R. Chu et al.   TISSUE ENGINEERING PART B-REVIEWS