The role of extracellular DNA in COVID-19: Clues from inflamm-aging

Ribosomal DNA instability: An evolutionary conserved fuel for inflammaging

(2020) Gianluca Storci et al.   AGEING RESEARCH REVIEWS

SARS-CoV-2 is an appropriate name for the new coronavirus

(2020) Yuntao Wu et al.   LANCET

The anti-viral dynamin family member MxB participates in mitochondrial integrity

(2020) Hong Cao et al.   Nature Communications

Sexual-dimorphism in human immune system aging

(2020) Eladio J. Márquez et al.   Nature Communications

Sex differences in inflammation, redox biology, mitochondria and autoimmunity

(2020) Damian N. Di Florio et al.   Redox Biology

Exploiting the telomere machinery to put the brakes on inflamm-aging

(2020) Massimiliano Bonafè et al.   AGEING RESEARCH REVIEWS

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes

(2020) Massimiliano Bonafè et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tocilizumab treatment in COVID-19: A single center experience

(2020) Pan Luo et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

The coronavirus pandemic in five powerful charts

(2020) Ewen Callaway et al.   NATURE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

(2020) Shufen Li et al.   Cell Reports

Impact of sex and gender on COVID-19 outcomes in Europe

(2020) Catherine Gebhard et al.   Biology of Sex Differences

COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians

(2020) Gabriella Marcon et al.   Aging-US

Telomeres and COVID‐19

(2020) Abraham Aviv   FASEB JOURNAL

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

(2020) Jasper Iske et al.   Nature Communications

Telomere damage induces internal loops that generate telomeric circles

(2020) Giulia Mazzucco et al.   Nature Communications

Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity

(2020) Johannes Burtscher et al.   iScience

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

(2019) Gianluca Storci et al.   CELL DEATH AND DIFFERENTIATION

Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

(2019) Jung Hwan Bae et al.   Cells

Telomere length in early childhood is associated with sex and ethnicity

(2019) Kien Ly et al.   Scientific Reports

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

(2019) Julio Aguado et al.   Nature Communications

Telomere biology and age-related diseases

(2018) Markus Herrmann et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells

(2018) Jenn‐Haung Lai et al.   EMBO REPORTS

The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

(2018) Kabilan Thurairajah et al.   European Journal of Trauma and Emergency Surgery

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging

(2018) Gianluca Storci et al.   SEMINARS IN IMMUNOLOGY

Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF‐κB activity

(2018) Carlos A. Puyo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The integration of inflammaging in age-related diseases

(2018) Tamas Fulop et al.   SEMINARS IN IMMUNOLOGY

Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort

(2017) Jennifer B Dowd et al.   JOURNAL OF INFECTIOUS DISEASES

Fetal and Placental DNA Stimulation of TLR9: A Mechanism Possibly Contributing to the Pro-inflammatory Events During Parturition

(2017) Ilona Telefus Goldfarb et al.   Reproductive Sciences

The Telomeric Response to Viral Infection

(2017) et al.   Viruses-Basel

Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress

(2016) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides

(2016) Defne Bayik et al.   PHARMACOLOGICAL RESEARCH

Neutrophil Extracellular Traps Go Viral

(2016) Günther Schönrich et al.   Frontiers in Immunology

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

(2015) Kyle Lapham et al.   GENETICS

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

(2015) Umeharu Ohto et al.   NATURE

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes

(2015) Zhuo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

(2015) Kyle Lapham et al.   GENETICS

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7- and TLR9-Mediated Immune Responses of Human Immune Cells

(2015) Franziska Römmler et al.   PLoS One

To sense or not to sense viral RNA—essentials of coronavirus innate immune evasion

(2014) Eveline Kindler et al.   CURRENT OPINION IN MICROBIOLOGY

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

(2014) R. E. Rigby et al.   EMBO JOURNAL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

(2013) Jon D. Simmons et al.   ANNALS OF SURGERY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Telomeres and age-related disease: how telomere biology informs clinical paradigms

(2013) Mary Armanios   JOURNAL OF CLINICAL INVESTIGATION

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

(2013) J. J. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures

(2013) R. W. Y. Chan et al.   JOURNAL OF VIROLOGY

Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus

(2013) F. Zielecki et al.   JOURNAL OF VIROLOGY

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis

(2013) Jinzhao Zhao et al.   PLoS One

Mitochondrial DNA: a proinflammatory ‘enemy from within’ during HIV infection?

(2012) M Pinti et al.   Cell Death & Disease

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

(2010) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9

(2010) Petar S. Lenert   MEDIATORS OF INFLAMMATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice

(2008) Noriyo Nagata et al.   AMERICAN JOURNAL OF PATHOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

(2008) Eva-K. Pauli et al.   PLoS Pathogens