Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

(2019) Yamei Han et al.   Nature Communications

Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.

(2019) Doyoung Kwon et al.   MOLECULAR PHARMACOLOGY

Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications

(2019) Doyoung Kwon et al.   Acta Pharmaceutica Sinica B

Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame

(2016) Sung-Mi Kim et al.   DRUG METABOLISM REVIEWS

CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

(2016) Sung-Mi Kim et al.   Scientific Reports

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

(2014) Jörn M. Schattenberg et al.   Redox Biology

Forkhead box class O transcription factors in liver function and disease

(2013) Irina Tikhanovich et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK

(2013) Defeng Wu et al.   Redox Biology

Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis

(2012) Tong-Fei Liu et al.   Cell Metabolism

Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis

(2012) Mohamed A. Abdelmegeed et al.   JOURNAL OF HEPATOLOGY

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system

(2012) Yien Che Tsai et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1

(2011) YongQiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

(2011) Hong Wa Yung et al.   PLoS One

Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease

(2009) Elango Kathirvel et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Structures of Human Cytochrome P-450 2E1

(2008) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From fatty streak to fatty liver: 33 years of joint publications in the JCI

(2008) Joseph L. Goldstein et al.   JOURNAL OF CLINICAL INVESTIGATION

SREBPs: the crossroads of physiological and pathological lipid homeostasis

(2008) Rajendra Raghow et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM