Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas

(2020) Wenzel M. Hackeng et al.   ENDOCRINE PATHOLOGY

A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1

(2019) Zhen Zhang et al.   Journal of Diabetes Research

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

(2019) Federico Gaiti et al.   NATURE

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors

(2019) Paloma Cejas et al.   NATURE MEDICINE

Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system

(2019) Xiafei Hong et al.   GUT

ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R

(2018) Emmanuel Paradis et al.   BIOINFORMATICS

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

The developmental origin of brain tumours: a cellular and molecular framework

(2018) Roberta Azzarelli et al.   DEVELOPMENT

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

(2018) Mariano J. Alvarez et al.   NATURE GENETICS

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

(2018) Felix Bormann et al.   Cell Reports

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

(2018) Matthias Thurner et al.   eLife

Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

(2018) Ben Lawrence et al.   npj Genomic Medicine

Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases

(2018) Antonio Pea et al.   ANNALS OF SURGERY

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

(2018) Chang S. Chan et al.   Nature Communications

Genetic and epigenetic drivers of neuroendocrine tumours (NET)

(2017) Annunziata Di Domenico et al.   ENDOCRINE-RELATED CANCER

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

(2017) Cornelia Jäkel et al.   Nature Communications

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

(2016) Ana C. Queirós et al.   CANCER CELL

Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation

(2016) Qian Xiao et al.   CANCER RESEARCH

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

(2016) Wenzel M. Hackeng et al.   HUMAN PATHOLOGY

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

(2016) M. Falconi et al.   NEUROENDOCRINOLOGY

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours

(2015) C. P. Pipinikas et al.   ENDOCRINE-RELATED CANCER

Frequency and Clinical Correlates of Somatic Ying Yang 1 Mutations in Sporadic Insulinomas

(2015) Urs D. Lichtenauer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Pax4 acts as a key player in pancreas development and plasticity

(2015) Tiziana Napolitano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

(2015) A. Sadanandam et al.   Cancer Discovery

Characterization of DNA Methylation in Circulating Tumor Cells

(2015) Constantin Pixberg et al.   Genes

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

(2014) Volker Hovestadt et al.   NATURE

Comprehensive analysis of DNA methylation data with RnBeads

(2014) Yassen Assenov et al.   NATURE METHODS

ChAMP: 450k Chip Analysis Methylation Pipeline

(2013) Tiffany J. Morris et al.   BIOINFORMATICS

TFcheckpoint: a curated compendium of specific DNA-binding RNA polymerase II transcription factors

(2013) Konika Chawla et al.   BIOINFORMATICS

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

(2012) Andrew E. Teschendorff et al.   BIOINFORMATICS

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility

(2012) Lovisa E. Reinius et al.   PLoS One

SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips

(2012) Jovana Maksimovic et al.   GENOME BIOLOGY

Malignant pancreatic neuroendocrine tumour: Lymph node ratio and Ki67 are predictors of recurrence after curative resections

(2011) Letizia Boninsegna et al.   EUROPEAN JOURNAL OF CANCER

A DNA methylation fingerprint of 1628 human samples

(2011) A. F. Fernandez et al.   GENOME RESEARCH

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

(2010) Matthew D. Wilkerson et al.   BIOINFORMATICS

Multiple Endocrine Neoplasia Type 1 Deletion in Pancreatic α-Cells Leads to Development of Insulinomas in Mice

(2010) H.-C. Jennifer Shen et al.   ENDOCRINOLOGY

α Cell–Specific Men1 Ablation Triggers the Transdifferentiation of Glucagon-Expressing Cells and Insulinoma Development

(2010) Jieli Lu et al.   GASTROENTEROLOGY

Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip

(2010) Christina Thirlwell et al.   METHODS

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE