NLRP1 Functions Downstream of the MAPK/ERK Signaling via ATF4 and Contributes to Acquired Targeted Therapy Resistance in Human Metastatic Melanoma

Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

(2020) Zili Zhai et al.   Cancers

The NLRP1 inflammasome pathway is silenced in cutaneous squamous cell carcinoma

(2019) Jennifer Sand et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Many ways to resistance: How melanoma cells evade targeted therapies

(2019) Ines Kozar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The NLRP3 inflammasome as pharmacological target

(2019) Carlo Marchetti   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inflammasome inhibitors: promising therapeutic approaches against cancer

(2019) Shengchao Xu et al.   Journal of Hematology & Oncology

Inhibition of ER stress-related IRE1α/CREB/NLRP1 pathway promotes the apoptosis of human chronic myelogenous leukemia cell

(2018) Zheng Xu et al.   MOLECULAR IMMUNOLOGY

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

Physiological/pathological ramifications of transcription factors in the unfolded protein response

(2017) Jaeseok Han et al.   GENES & DEVELOPMENT

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

(2017) Helen L. Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma

(2017) Z Zhai et al.   ONCOGENE

MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway

(2017) Radoslav Janostiak et al.   Cell Reports

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

(2017) Marco Corazzari et al.   Frontiers in Oncology

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

(2016) Franklin L. Zhong et al.   CELL

Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor- B Signaling for Cancer Treatment

(2016) K. P. Zeligs et al.   CLINICAL CANCER RESEARCH

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

(2015) Souvik Dey et al.   JOURNAL OF CLINICAL INVESTIGATION

Aspirin therapy inhibits NLRP1 (nucleotide-binding domain-like receptor protein 1) inflammasome gene expression in patients with peripheral artery disease

(2015) Silvia Bleda et al.   JOURNAL OF VASCULAR SURGERY

Transcriptional repression of IFNβ1 by ATF2 confers melanoma resistance to therapy

(2015) E Lau et al.   ONCOGENE

Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress

(2015) Andrea D’Osualdo et al.   PLoS One

BRAFV600E melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity

(2014) C A Whipple et al.   BRITISH JOURNAL OF CANCER

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor heterogeneity and plasticity as elusive drivers for resistance to MAPK pathway inhibition in melanoma

(2014) A Roesch   ONCOGENE

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies

(2014) Martina McDermott et al.   Frontiers in Oncology

Transcriptome Profiling Identifies HMGA2 as a Biomarker of Melanoma Progression and Prognosis

(2013) Leon Raskin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1  processing via the NLRP1 inflammasome

(2013) C. B. Levandowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma

(2012) J. S. Khalili et al.   CLINICAL CANCER RESEARCH

Targeting the ATF4 pathway in cancer therapy

(2012) Dean C Singleton et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

(2012) Simona Caporali et al.   Journal of Translational Medicine

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

(2012) Deepti Verma et al.   Pigment Cell & Melanoma Research

Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells

(2012) Chien-Ju Lin et al.   PLoS One

Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion

(2011) Lixia Z. Ellis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma

(2011) Y. Qin et al.   MOLECULAR CANCER RESEARCH

Clonogenic Assay: Adherent Cells

(2011) Haloom Rafehi et al.   Jove-Journal of Visualized Experiments

RSK2 mediates NF-κB activity through the phosphorylation of IκBα in the TNF-R1 pathway

(2010) Cong Peng et al.   FASEB JOURNAL

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

(2009) Miyako Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK Activity Is Essential forAtf4Expression and Late-Stage Osteoblast Differentiation

(2008) Tetsuya Matsuguchi et al.   JOURNAL OF BONE AND MINERAL RESEARCH