Stem Cell-Derived Exosomes Ameliorate Doxorubicin-Induced Muscle Toxicity through Counteracting Pyroptosis

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism

(2019) Rendong Fang et al.   Mucosal Immunology

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis

(2019) Zahra Tavakoli Dargani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization

(2019) Shengqiong Deng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of Behavioral and Pelvic Floor Muscle Therapy Combined With Surgery vs Surgery Alone on Incontinence Symptoms Among Women With Mixed Urinary Incontinence

(2019) Vivian W. Sung et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway

(2019) Ming Zhang et al.   Biomed Research International

Doxorubicin‐induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

(2019) Anouk E. Hiensch et al.   Acta Physiologica

Exosome Treatment Enhances Anti-Inflammatory M2 Macrophages and Reduces Inflammation-Induced Pyroptosis in Doxorubicin-Induced Cardiomyopathy

(2019) Dinender K. Singla et al.   Cells

Research progresses of molecular mechanism of pyroptosis and its related diseases

(2019) Weihua Gong et al.   IMMUNOBIOLOGY

The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis

(2019) Jiang-Yuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Hypoxia-Induced ROS Contribute to Myoblast Pyroptosis during Obstructive Sleep Apnea via the NF-κB/HIF-1α Signaling Pathway

(2019) Li-Ming Yu et al.   Oxidative Medicine and Cellular Longevity

Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells

(2018) Zahra Tavakoli Dargani et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection

(2018) Ka Tik Cheung et al.   IMMUNOBIOLOGY

NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass

(2018) Lei Hou et al.   LABORATORY INVESTIGATION

MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis

(2018) Peng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

(2018) Dandan Li et al.   Molecular Medicine Reports

Secreted Frizzled-Related Protein-2 Inhibits Doxorubicin-Induced Apoptosis Mediated through the Akt-mTOR Pathway in Soleus Muscle

(2018) Hilda Merino et al.   Oxidative Medicine and Cellular Longevity

Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis

(2018) Heidi Shoulders et al.   Translational Research

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid

(2017) Olga Gordeeva et al.   Stem Cells International

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

(2017) Carolina Pellegrini et al.   Frontiers in Immunology

Modulation of MAPK and NF-κB Signaling Pathways by Antioxidant Therapy in Skeletal Muscle of Heart Failure Rats

(2016) Paula F. Martinez et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2

(2016) J-C Ryu et al.   Mucosal Immunology

BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo E-/- Mice

(2016) Dinender K. Singla et al.   PLoS One

Inflammation and Pyroptosis Mediate Muscle Expansion in an Interleukin-1β (IL-1β)-dependent Manner

(2015) Subhash Haldar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

(2015) Dinender K. Singla et al.   PLoS One

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart

(2014) Stefano Toldo et al.   CARDIOVASCULAR RESEARCH

Exosomes and Cardiac Repair After Myocardial Infarction

(2014) Susmita Sahoo et al.   CIRCULATION RESEARCH

Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair

(2013) Yacine Kharraz et al.   MEDIATORS OF INFLAMMATION

Transplanted Induced Pluripotent Stem Cells Mitigate Oxidative Stress and Improve Cardiac Function through the Akt Cell Survival Pathway in Diabetic Cardiomyopathy

(2013) Binbin Yan et al.   MOLECULAR PHARMACEUTICS

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Measuring the Strength of Mice

(2013) Robert M.J. Deacon   Jove-Journal of Visualized Experiments

Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis

(2012) Mohammed G. Ghonime et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Embryonic Stem Cells Improve Cardiac Function in Doxorubicin-Induced Cardiomyopathy Mediated through Multiple Mechanisms

(2012) Dinender K. Singla et al.   CELL TRANSPLANTATION

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Chemotherapy-Induced Weakness and Fatigue in Skeletal Muscle: The Role of Oxidative Stress

(2011) Laura A.A. Gilliam et al.   ANTIOXIDANTS & REDOX SIGNALING

Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle

(2011) Ashley J. Smuder et al.   JOURNAL OF APPLIED PHYSIOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Normal myogenesis and increased apoptosis in myotonic dystrophy type-1 muscle cells

(2010) E Loro et al.   CELL DEATH AND DIFFERENTIATION

Sterile inflammatory responses mediated by the NLRP3 inflammasome

(2010) Suzanne L. Cassel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Drug-related Myopathies of Which the Clinician Should Be Aware

(2010) Ritu Valiyil et al.   Current Rheumatology Reports

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies

(2009) Hannes Hentze et al.   Stem Cell Research

Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy

(2007) Xu-Jun Qin et al.   JOURNAL OF APPLIED TOXICOLOGY