Review
Biochemistry & Molecular Biology
Natsuki Morimoto, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: PRRs, including NLRs, play important roles in inducing inflammatory responses through recognizing various patterns. The activation of inflammasome leads to the maturation of proinflammatory cytokines and pyroptosis, which play protective roles against pathogen infection in mammals and teleosts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Valentina Arre, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo, Roberto Negro
Summary: The NLRP3 inflammasome is an essential component of the innate immune system involved in danger recognition. Its activation can lead to cell death and the production of pro-inflammatory cytokines, but excessive activation can cause inflammatory bowel disease and gastrointestinal cancer. Research shows that the NLRP3 inflammasome has both protective and pathogenic abilities.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao
Summary: Pyroptosis is a lytic programmed cell death that plays a crucial role in diabetic complications. Research has identified various signaling pathways associated with pyroptosis, and explored the potential value of pyroptosis inhibitors in the treatment of diabetic nephropathy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jianhua Wang, Lichun Wang, Xiaofei Zhang, Yanfen Xu, Lei Chen, Weiyu Zhang, Enhe Liu, Chaoxing Xiao, Qiuye Kou
Summary: The study demonstrates that CTSB may exacerbate AP by activating the NLRP3 inflammasome and promoting Caspase-1-induced pyroptosis. Inhibiting CTSB not only reduces pancreatic inflammation but also suppresses the expression and activity of other inflammatory factors related to AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liang Yan, Yi Liu, Xue-feng Ma, Dan Hou, Yu-hui Zhang, Yong Sun, Shan-shan Shi, Tim Forouzanfar, Hai-yan Lin, Jun Fan, Gang Wu
Summary: Triclabendazole induces GSDME-dependent pyroptosis by activating caspase-3, and this process is at least partly through enhancing the ROS/JNK/Bax-mitochondrial apoptotic pathway, leading to significant inhibition of breast cancer cell growth.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Remi Planes, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadao, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Michele Tiraby, Qian Zhang, Pietro Cicuta, Emmanuelle Jouanguy, Olivier Neyrolles, Clare E. Bryant, Andres R. Floto, Caroline Goujon, Franklin Zhong Lei, Guillaume Martin-Blondel, Stein Silva, Jean-Laurent Casanova, Celine Cougoule, Bruno Reversade, Julien Marcoux, Emmanuel Ravet, Etienne Meunier
Summary: The activation of inflammasomes plays a crucial role in regulating the infection of SARS-CoV-2. Lung epithelial cells serve as the primary entry site of the virus and express the inflammasome-forming sensor NLRP1. The cleavage of NLRP1 by coronavirus 3CL proteases leads to inflammasome assembly, cell death, and reduced production of viral particles. Additionally, these proteases also inactivate the executioner protein Gasdermin D, promoting an alternative form of cell death called pyroptosis. Analysis of pyroptosis markers in COVID-19 patients suggests that GSDME/caspase-3 could potentially serve as markers of disease severity.
Article
Immunology
Fan Yang, Xun-jia Ye, Ming-ye Chen, Hong-chun Li, Yao-feng Wang, Mei-yan Zhong, Chun-su Zhong, Bo Zeng, Li-hui Xu, Xian-hui He, Dong-yun Ouyang
Summary: Taraxasterol (TAS), an active ingredient of Dandelion, has been found to inhibit NLRP3 inflammasome activation in macrophages, thus exerting anti-inflammatory effects likely through regulation of the mTOR signaling pathway. This highlights a potential mechanism for the anti-inflammatory activity of Dandelion in treating inflammation-related disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian A. Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P. Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A. Conos, Daniel Frank, Daniel S. Simpson, James M. Murphy, Kate E. Lawlor, Jaclyn S. Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K. H. Poon, Seth L. Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E. Vince
Summary: This study reveals that genetic mutations in X-linked inhibitor of apoptosis (XIAP) can lead to cell death-associated inflammatory diseases. The findings show that patients with XIAP deficiency-associated inflammatory bowel disease have increased inflammatory IL-1 beta maturation and cell death-associated caspase-8 and Gasdermin D (GSDMD) processing, which can be reduced by patient treatment.
Article
Fisheries
Juan M. Lozano-Gil, Lola Rodriguez-Ruiz, Sylwia D. Tyrkalska, Diana Garcia-Moreno, Ana B. Perez-Oliva, Victoriano Mulero
Summary: This study utilized a zebrafish model to show that inhibition of myeloid cell inflammasome led to an increase in specific immune cells during inflammation. The findings suggest that myeloid inflammasome autonomously regulates pyroptotic cell death in chronic inflammation through a Gasdermin E-dependent pathway.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Cell Biology
Omar Escobar-Chavarria, Alejandro Benitez-Guzman, Itzel Jimenez-Vazquez, Jacobo Carrisoza-Urbina, Lourdes Arriaga-Pizano, Sara Huerta-Yepez, Guillermina Baay-Guzman, Jose A. Gutierrez-Pabello
Summary: The necrotic cell death induced by Mycobacterium bovis and the inflammasome activation in bovine macrophages help control bacterial growth.
Review
Cardiac & Cardiovascular Systems
Xinzhe Chen, Peng-Chao Tian, Kai Wang, Man Wang, Kun Wang
Summary: Cardiovascular disease (CVD) is a common and serious health threat. Different forms of cardiomyocyte death, including apoptosis, necrosis, and pyroptosis, play important roles in the pathogenesis of CVD. Controlling cardiomyocyte pyroptosis holds promise for the treatment of cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Dengqiang Wu, Yujie Li, Ranxing Xu
Summary: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with undefined causes, leading to persistent synovial inflammation and destruction of articular cartilage and bone. Current drugs for RA can relieve joint symptoms, but there are limitations and the need for new mechanisms to prevent and treat RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Beatrice I. Herrmann, James P. Grayczyk, Igor E. Brodsky
Summary: The immune system of multicellular organisms defends against harmful microbes. Bacterial infection can influence the formation and activity of inflammasomes, which are responsible for activating cell death pathways and triggering proinflammatory responses. This review examines how bacterial activities impact inflammasomes and the consequences for both the host and pathogen.
ANNUAL REVIEW OF MICROBIOLOGY
(2023)
Review
Oncology
Lei Wang, Xiaowei Qin, Jianmin Liang, Pengfei Ge
Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Meini Chen, Rong Rong, Xiaobo Xia
Summary: Pyroptosis is a type of programmed cell death characterized by rapid plasma membrane disruption and release of pro-inflammatory mediators. Recent studies have shown its involvement in various ocular diseases. This review summarizes the role of pyroptosis in common ocular diseases and suggests that targeting pyroptosis signaling pathways could be a potential therapeutic strategy.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Jun-xia Ma, Jiang-yuan Li, Dong-dong Fan, Wei Feng, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Jiang-yuan Li, Ke Gao, Tong Shao, Dong-dong Fan, Chong-bin Hu, Cen-cen Sun, Wei-ren Dong, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Wei Shi, Tong Shao, Jiang-yuan Li, Dong-dong Fan, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao
JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Jian Lu, Raheel Ahmad, Thomas Nguyen, Jeffrey Cifello, Humza Hemani, Jiangyuan Li, Jinguo Chen, Siyi Li, Jing Wang, Achouak Achour, Joseph Chen, Meagan Colie, Ana Lustig, Christopher Dunn, Linda Zukley, Chee W. Chia, Irina Burd, Jun Zhu, Luigi Ferrucci, Nan-Ping Weng
Summary: The decline of CD8(+) T cell functions with aging is a significant health issue, and this study uses single-cell RNA sequencing and machine learning to understand the mechanisms and predict the age of individual cells. This research has important implications for predicting functional outcomes in vaccination or infection.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Cen-Cen Sun, Wei-Ren Dong, Tong Shao, Jiang-Yuan Li, Jing Zhao, Li Nie, Li-Xin Xiang, Guan Zhu, Jian-Zhong Shao
BIOCHEMICAL JOURNAL
(2017)