Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics
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Title
Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics
Authors
Keywords
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Journal
Antibiotics-Basel
Volume 10, Issue 1, Pages 92
Publisher
MDPI AG
Online
2021-01-20
DOI
10.3390/antibiotics10010092
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Note: Only part of the references are listed.- Diarylureas as Antitumor Agents
- (2021) Alessia Catalano et al. Applied Sciences-Basel
- Schistosomiasis—from immunopathology to vaccines
- (2020) Donald P. McManus et al. Seminars in Immunopathology
- The COVID‐19 epidemic
- (2020) Thirumalaisamy P. Velavan et al. TROPICAL MEDICINE & INTERNATIONAL HEALTH
- SCORE Operational Research on Moving toward Interruption of Schistosomiasis Transmission
- (2020) Carl H. Campbell et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- COVID-19 and Multiorgan Response
- (2020) Sevim Zaim et al. CURRENT PROBLEMS IN CARDIOLOGY
- Multiple Bioassays and Targeted and Nontargeted Analyses to Characterize Potential Toxicological Effects Associated with Sediments of Masan Bay: Focusing on AhR-Mediated Potency
- (2020) Junghyun Lee et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
- (2020) Philippe Gautret et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- COVID‐19 diagnosis and management: a comprehensive review
- (2020) Giuseppe Pascarella et al. JOURNAL OF INTERNAL MEDICINE
- Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as a Molecular Target of Triclocarban
- (2020) Robert Macsics et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors
- (2020) Mario Gennaro Mazza et al. BRAIN BEHAVIOR AND IMMUNITY
- Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections
- (2020) Igor José dos Santos Nascimento et al. CURRENT MEDICINAL CHEMISTRY
- Pathogenesis and treatment of idiopathic and rheumatoid arthritis-related interstitial pneumonia. The possible lesson from COVID-19 pneumonia
- (2020) A Manfredi et al. Expert Review of Clinical Immunology
- The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus
- (2020) Wooseong Kim et al. mBio
- α–ω Alkenyl‐bis‐ S ‐Guanidine Thiourea Dihydrobromide Affects HeLa Cell Growth Hampering Tubulin Polymerization
- (2020) Jessica Ceramella et al. ChemMedChem
- Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
- (2020) Adewale Oluwaseun Fadaka et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- COVID-19 and multiorgan failure: A narrative review on potential mechanisms
- (2020) Tahmineh Mokhtari et al. JOURNAL OF MOLECULAR HISTOLOGY
- Target and suspect screening analysis reveals persistent emerging organic contaminants in soils and sediments
- (2020) Aurea C. Chiaia-Hernández et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Recent Progress in the Development of Liver Fluke and Blood Fluke Vaccines
- (2020) Donald P. McManus Vaccines
- The fate of triclocarban in activated sludge and its influence on biological wastewater treatment system
- (2020) Yali Wang et al. JOURNAL OF ENVIRONMENTAL MANAGEMENT
- Covid-19: New coronavirus variant is identified in UK
- (2020) Jacqui Wise BMJ-British Medical Journal
- COVID-19 pneumonia and the appropriate use of antibiotics
- (2020) Amy Sarah Ginsburg et al. Lancet Global Health
- Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets
- (2020) Krishna Sriram et al. PHYSIOLOGICAL REVIEWS
- Drug repurposing for antimicrobial discovery
- (2019) Maya A. Farha et al. Nature Microbiology
- Carbazole Derivatives as Antiviral Agents: An Overview
- (2019) Caruso et al. MOLECULES
- Recent update on anti-dengue drug discovery
- (2019) Satish N. Dighe et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection
- (2019) Ronik Khachatoorian et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease
- (2019) Enrica Pietronigro et al. Scientific Reports
- Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
- (2019) Philipp Le et al. Nature Chemistry
- Fate, risk and removal of triclocarban: A critical review
- (2019) Hui Yun et al. JOURNAL OF HAZARDOUS MATERIALS
- Identification of novel small-molecule inhibitors of Zika virus infection
- (2018) Ewa D. Micewicz et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Progress in antischistosomal N , N ′-diaryl urea SAR
- (2018) Jianbo Wu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabonomics Indicates Inhibition of Fatty Acid Synthesis, β-Oxidation, and Tricarboxylic Acid Cycle in Triclocarban-Induced Cardiac Metabolic Alterations in Male Mice
- (2018) Wenping Xie et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Chemotherapy for Fighting Schistosomiasis: Past, Present and Future
- (2018) Patrick Mäder et al. ChemMedChem
- Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists
- (2018) Jingjing Peng et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Schistosomiasis
- (2018) Donald P. McManus et al. Nature Reviews Disease Primers
- Pentafluorosulfanyl-containing Triclocarban Analogs with Potent Antimicrobial Activity
- (2018) Eugènia Pujol et al. MOLECULES
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus
- (2017) Ibrahim H. Eissa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea
- (2017) Anand Babu Velappan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design
- (2017) Fatiha Benmansour et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York
- (2017) Laura A. Geer et al. JOURNAL OF HAZARDOUS MATERIALS
- Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution
- (2017) Thuy Nguyen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1
- (2017) Leepakshi Khurana et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and SAR studies of potent H+/K+-ATPase and anti-inflammatory activities of symmetrical and unsymmetrical urea analogues
- (2017) Kadalipura P. Rakesh et al. MEDICINAL CHEMISTRY RESEARCH
- Immunoregulatory Role of Cannabinoids during Infectious Disease
- (2017) Rosalía Hernández-Cervantes et al. NEUROIMMUNOMODULATION
- AIDS, Avian flu, SARS, MERS, Ebola, Zika… what next?
- (2017) Leslie A. Reperant et al. VACCINE
- The global burden of disease study 2013: What does it mean for the NTDs?
- (2017) Jennifer R. Herricks et al. PLoS Neglected Tropical Diseases
- Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus
- (2017) Haroon Mohammad et al. PLoS One
- Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation
- (2016) Zhiwei Feng et al. AAPS Journal
- Design and synthesis of some new 1-phenyl-3/4-[4-(aryl/heteroaryl/alkyl-piperazine1-yl)-phenyl-ureas as potent anticonvulsant and antidepressant agents
- (2016) Chandra Bhushan Mishra et al. ARCHIVES OF PHARMACAL RESEARCH
- Antischistosomal activity of N,N′-arylurea analogs against Schistosoma japonicum
- (2016) Houzong Yao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Diaryl Urea: A Privileged Structure in Anticancer Agents
- (2016) Laura Garuti et al. CURRENT MEDICINAL CHEMISTRY
- Design, Synthesis and Structure-Activity Relationships of Novel Diaryl Urea Derivatives as Potential EGFR Inhibitors
- (2016) Nan Jiang et al. MOLECULES
- T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time
- (2016) Ikuo Miyahisa et al. ACS Medicinal Chemistry Letters
- Activities ofN,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni
- (2015) Noemi Cowan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Up-regulated integrinα4β1 on systemic lymphocytes and serum IL-17A in interstitial pneumonia
- (2015) Yasuyuki Taooka et al. Clinical Respiratory Journal
- Potential of aryl–urea–benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease
- (2015) Belma Zengin Kurt et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- In vitroandin vivoactivity of a novel sorafenib derivative SC5005 against MRSA
- (2015) Han-Chu Chang et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases
- (2015) Jane L. Roberts et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Two disparate ligand-binding sites in the human P2Y1 receptor
- (2015) Dandan Zhang et al. NATURE
- Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni
- (2015) Noemi Cowan et al. Parasites & Vectors
- Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent
- (2014) Yoon T. Jeon et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution
- (2014) Jennifer X. Qiao et al. ChemMedChem
- Discovery of 4-Aryl-7-Hydroxyindoline-Based P2Y1 Antagonists as Novel Antiplatelet Agents
- (2014) Wu Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box
- (2014) Katrin Ingram-Sieber et al. PLoS Neglected Tropical Diseases
- Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility
- (2013) Tammy C. Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist
- (2013) Jennifer X. Qiao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of 2-(Phenoxypyridine)-3-phenylureas as Small Molecule P2Y1 Antagonists
- (2013) Hannguang Chao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties
- (2013) Bedia Kocyigit-Kaymakcioglu et al. MOLECULES
- The structure ofEnterococcus faecalisthymidylate synthase provides clues about folate bacterial metabolism
- (2012) Cecilia Pozzi et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties
- (2012) Ashish P. Keche et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel diaryl ureas with efficacy in a mouse model of malaria
- (2012) John W. Anderson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model
- (2011) Jun-Yan Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Evaluation of Diarylureas for Activity Against Plasmodium falciparum
- (2010) Yiqun Zhang et al. ACS Medicinal Chemistry Letters
- Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis
- (2009) Ram Shankar Upadhayaya et al. BIOORGANIC & MEDICINAL CHEMISTRY
- PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats
- (2007) J G Horswill et al. BRITISH JOURNAL OF PHARMACOLOGY
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