The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus

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A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

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Bacterial Persisters and Infection: Past, Present, and Progressing

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Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells

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Therapeutic Targeting of the IGF Axis

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Recent development of membrane-active molecules as antibacterial agents

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Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

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Progress in antischistosomal N , N ′-diaryl urea SAR

(2018) Jianbo Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Antibiotic Tolerance, Pathogen by Pathogen

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Influence of subinhibitory concentrations of NH125 on biofilm formation & virulence factors of Staphylococcus aureus

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A new class of synthetic retinoid antibiotics effective against bacterial persisters

(2018) Wooseong Kim et al.   NATURE

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters

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Automated Topology Builder Version 3.0: Prediction of Solvation Free Enthalpies in Water and Hexane

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An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs

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Protonation Kinetics Compromise Liposomal Fluorescence Assay of Membrane Permeation

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Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations

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Transfer of Antibiotic Resistance in Staphylococcus aureus

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Three-Dimensional Graphene-Based Microbarriers for Controlling Release and Reactivity in Colloidal Liquid Phases

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Antimicrobial peptides

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Diaryl Urea: A Privileged Structure in Anticancer Agents

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Mechanisms and consequences of bacterial resistance to antimicrobial peptides

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NH125 kills methicillin-resistantStaphylococcus aureuspersisters by lipid bilayer disruption

(2016) Wooseong Kim et al.   Future Medicinal Chemistry

PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells

(2016) Xiang Zhou et al.   JOURNAL OF CHEMOTHERAPY

Diversity, evolution and medical applications of insect antimicrobial peptides

(2016) Eleftherios Mylonakis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles

(2016) Wenpeng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides

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Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci

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Induced Bacterial Cross-Resistance toward Host Antimicrobial Peptides: A Worrying Phenomenon

(2016) Osmel Fleitas et al.   Frontiers in Microbiology

Persister formation in Staphylococcus aureus is associated with ATP depletion

(2016) Brian P. Conlon et al.   Nature Microbiology

Activities ofN,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

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Membrane-Active Small Molecules: Designs Inspired by Antimicrobial Peptides

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Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

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Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy

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N-terminal aromatic tag induced self assembly of tryptophan–arginine rich ultra short sequences and their potent antibacterial activity

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Heterogeneity ofmprFSequences in Methicillin-Resistant Staphylococcus aureus Clinical Isolates: Role in Cross-Resistance between Daptomycin and Host Defense Antimicrobial Peptides

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Interaction of Daptomycin with Lipid Bilayers: A Lipid Extracting Effect

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Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: A review

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Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus

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Phenotypic and Genotypic Characterization of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Strains: Relative Roles of mprF and dlt Operons

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Bio-inspired resin acid-derived materials as anti-bacterial resistance agents with unexpected activities

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Identification of an Inhibitory Mechanism of Luteolin on the Insulin-Like Growth Factor-1 Ligand-Receptor Interaction

(2013) Yong Yang et al.   CHEMBIOCHEM

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets

(2013) Yusong Tu et al.   Nature Nanotechnology

Process of inducing pores in membranes by melittin

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A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes

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Caenorhabditis elegans-based Model Systems for Antifungal Drug Discovery

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The structure–activity relationship of urea derivatives as anti-tuberculosis agents

(2011) Joshua R. Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Transmembrane Pores Formed by Human Antimicrobial Peptide LL-37

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Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

(2011) Alpeshkumar K. Malde et al.   Journal of Chemical Theory and Computation

Direct Visualization of Bactericidal Action of Cationic Conjugated Polyelectrolytes and Oligomers

(2011) Ying Wang et al.   LANGMUIR

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

g_wham—A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates

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Observing the Solubilization of Lipid Bilayers by Detergents with Optical Microscopy of GUVs

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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Evaluation of Diarylureas for Activity Against Plasmodium falciparum

(2010) Yiqun Zhang et al.   ACS Medicinal Chemistry Letters

Identification and Rational Design of Novel Antimicrobial Peptides for Plant Protection

(2008) Jose F. Marcos et al.   Annual Review of Phytopathology

Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors

(2008) Afshin Zarghi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES

The bacterial envelope as a target for novel anti-MRSA antibiotics

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