Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease

(2019) Isabelle St-Amour et al.   Journal of Neuroinflammation

A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease

(2018) Vladimira Durmanova et al.   MEDIATORS OF INFLAMMATION

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

Anti-α4β1 integrin antibodies attenuated brain inflammatory changes in a mouse model of Alzheimer’s disease

(2018) Colin Combs et al.   Current Alzheimer Research

The vascular basement membrane in the healthy and pathological brain

(2017) Maj S Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

Tau passive immunization inhibits not only tau but also Aβ pathology

(2017) Chun-ling Dai et al.   Alzheimers Research & Therapy

NETosis in Alzheimer’s Disease

(2017) Enrica Caterina Pietronigro et al.   Frontiers in Immunology

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis

(2016) M.T. Ferretti et al.   BRAIN BEHAVIOR AND IMMUNITY

Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

(2015) S. Massena et al.   BLOOD

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease

(2015) Gero Lueg et al.   NEUROBIOLOGY OF AGING

Early changes in extracellular matrix in Alzheimer's disease

(2015) F.-X. Lepelletier et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Clinical significance of circulating vascular cell adhesion molecule-1 to white matter disintegrity in Alzheimer’s dementia

(2015) Chi-Wei Huang et al.   THROMBOSIS AND HAEMOSTASIS

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

(2015) Nadine Herr et al.   Jove-Journal of Visualized Experiments

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

Crosstalk between CXCR4/Stromal Derived Factor-1 and VLA-4/VCAM-1 Pathways Regulates Neutrophil Retention in the Bone Marrow

(2014) J. M. Petty et al.   JOURNAL OF IMMUNOLOGY

IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology

(2014) Isabelle St-Amour et al.   Journal of Neuroinflammation

Early Treatment with Anti-VLA-4 mAb Can Prevent the Infiltration and/or Development of Pathogenic CD11b+CD4+ T Cells in the CNS during Progressive EAE

(2014) John E. Mindur et al.   PLoS One

Progressive multifocal leukoencephalopathy in patients with multiple sclerosis

(2013) Kelly J. Baldwin et al.   CURRENT OPINION IN NEUROLOGY

Use of imaging to study leukocyte trafficking in the central nervous system

(2013) Elena Zenaro et al.   IMMUNOLOGY AND CELL BIOLOGY

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

(2013) Róisín M. McManus et al.   NEUROBIOLOGY OF AGING

Impact of Natalizumab on Cognitive Performances and Fatigue in Relapsing Multiple Sclerosis: A Prospective, Open-Label, Two Years Observational Study

(2012) Pietro Iaffaldano et al.   PLoS One

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report

(2010) Stefano Sotgiu et al.   BMC Neurology

Essential roles of VLA-4 in the hematopoietic system

(2010) Yoichi Imai et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions

(2010) B. Rossi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia

(2008) G. Zuliani et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE