Disrupted H2S Signaling by Cigarette Smoking and Alcohol Drinking: Evidence from Cellular, Animal, and Clinical Studies

Highlight article: Hydrogen sulfide alleviates cigarette smoke-induced COPD through inhibition of the TGF-β1/smad pathway

(2020) Liang Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hydrogen Sulfide Attenuates the Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders

(2020) Fahimeh Mohseni et al.   NEUROTOXICITY RESEARCH

Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice

(2020) Amr Ali et al.   LIFE SCIENCES

Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally

(2020) Shashi P. Singh et al.   Frontiers in Immunology

Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke

(2020) Fang Lei et al.   PLoS One

Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect

(2019) Xiang Yan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke

(2019) Teodora Ivanciuc et al.   PEDIATRIC RESEARCH

Sulphurous thermal water inhalation impacts respiratory metabolic parameters in heavy smokers

(2019) Cecilia Carubbi et al.   INTERNATIONAL JOURNAL OF BIOMETEOROLOGY

S‐allyl‐L‐cysteine ( SAC ) protects hepatocytes from alcohol‐induced apoptosis

(2019) Peng Chen et al.   FEBS Open Bio

Alcohol consumption or cigarette smoking and cardiovascular disease risk in youth with type 1 diabetes

(2019) Giuliana Valerio et al.   ACTA DIABETOLOGICA

Direct Proteomic Mapping of Cysteine Persulfidation

(2019) Ling Fu et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1α/MAPK signaling pathway

(2019) Ruijuan Guan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sulfane sulfur – new findings on an old topic

(2019) Malgorzata Iciek et al.   ACTA BIOCHIMICA POLONICA

Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1

(2019) Ruijuan Guan et al.   Aging-US

Ethanol-induced gastric ulcer in rats and intervention of tert-butylhydroquinone: Involvement of Nrf2/HO-1 signalling pathway

(2019) Z Rahman et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Hydrogen sulfide improves spatial memory impairment via increases of BDNF expression and hippocampal neurogenesis following early postnatal alcohol exposure

(2019) Fahimeh Mohseni et al.   PHYSIOLOGY & BEHAVIOR

Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway

(2019) Ruijuan Guan et al.   Redox Biology

Is aldehyde dehydrogenase inhibited by sulfur compounds? In vitro and in vivo studies

(2018) Małgorzata Iciek et al.   ACTA BIOCHIMICA POLONICA

Evaluating the effect of diallyl sulfide on regulation of inflammatory mRNA expression in 3T3L1 adipocytes and RAW 264.7 macrophages during ethanol treatment

(2018) Venkata Harini Kema et al.   DRUG AND CHEMICAL TOXICOLOGY

Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects

(2018) Xiang Yan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

Mesenchymal stem cells attenuate adriamycin-induced nephropathy by diminishing oxidative stress and inflammation via downregulation of the NF-kB

(2018) In-Hwan Song et al.   NEPHROLOGY

Hydrogen sulfide alleviates placental injury induced by maternal cigarette smoke exposure during pregnancy in rats

(2018) Fusheng Zhao et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

AMPK activation promotes gastroprotection through mutual interaction with the gaseous mediators H 2 S, NO, and CO

(2018) Simone de Araújo et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

(2018) Yuchuan Wang et al.   PHARMACEUTICAL BIOLOGY

The detection and quantification, in vivo and in real time, of hydrogen sulfide in ethanol-induced lesions in rat stomachs using an ion sensitive electrode

(2018) Josué A. Velázquez-Moyado et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking

(2018) Stephanie S. O’Malley et al.   JAMA Psychiatry

Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats

(2018) Fusheng Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy

(2017) Biao Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation

(2017) Youngjun Ju et al.   MOLECULES

Evidence that d-cysteine protects mice from gastric damage via hydrogen sulfide produced by d-amino acid oxidase

(2017) Luan Kelves M. Souza et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Reducing Smoking in the US Federal Workforce: 5-Year Health and Economic Impacts From Improved Cardiovascular Disease Outcomes

(2017) Garrett R. Beeler Asay et al.   PUBLIC HEALTH REPORTS

Hydrogen sulfide ameliorates prenatal cigarette smoke exposure-induced impairment of respiratory responses to hypercapnia in neonatal rats

(2017) Senfeng Zhang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The Role of Cystathionine-γ-Lyase In Blunt Chest Trauma in Cigarette Smoke Exposed Mice

(2017) Clair Hartmann et al.   SHOCK

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

(2017) Takaaki Akaike et al.   Nature Communications

Hydrogen Sulfide Inhibits Cigarette Smoke-Induced Endoplasmic Reticulum Stress and Apoptosis in Bronchial Epithelial Cells

(2017) Fan Lin et al.   Frontiers in Pharmacology

Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification

(2017) Hui Li et al.   Frontiers in Pharmacology

Diligustilide releases H2S and stabilizes S-nitrosothiols in ethanol-induced lesions on rat gastric mucosa

(2017) Josué Arturo Velázquez-Moyado et al.   INFLAMMOPHARMACOLOGY

Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis

(2016) Lian-Yun Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD)

(2016) Jeffrey R. Wozniak et al.   Brain Imaging and Behavior

Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism

(2016) Lian-Yun Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The effects of changes in glutathione levels through exogenous agents on intracellular cysteine content and protein adduct formation in chronic alcohol-treated VL17A cells

(2016) S. Mathan Kumar et al.   TOXICOLOGY MECHANISMS AND METHODS

The effects of changes in glutathione levels through exogenous agents on intracellular cysteine content and protein adduct formation in chronic alcohol-treated VL17A cells

(2016) S. Mathan Kumar et al.   TOXICOLOGY MECHANISMS AND METHODS

S-Sulfhydration: A Cysteine Posttranslational Modification in Plant Systems

(2015) Ángeles Aroca et al.   PLANT PHYSIOLOGY

Investigation of Hydrogen Sulfide Exposure and Lung Function, Asthma and Chronic Obstructive Pulmonary Disease in a Geothermal Area of New Zealand

(2015) Michael N. Bates et al.   PLoS One

H 2 S: A Novel Gasotransmitter that Signals by Sulfhydration

(2015) Bindu D. Paul et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity

(2015) Yun Sun et al.   Scientific Reports

Protective Role of CYP2E1 Inhibitor Diallyl Disulfide (DADS) on Alcohol-Induced Malondialdehyde-Deoxyguanosine (M1dG) Adduct Formation

(2014) Muna Sapkota et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Hydrogen sulfide improves left ventricular function in smoking rats via regulation of apoptosis and autophagy

(2014) Xiang Zhou et al.   APOPTOSIS

Regulation of cystathionine gamma-lyase/H2S system and its pathological implication

(2014) Kexin Zhao   Frontiers in Bioscience-Landmark

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Effect of Nicotine on RANKL and OPG and Bone Mineral Density

(2014) Soycan Mizrak et al.   JOURNAL OF INVESTIGATIVE SURGERY

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD

(2014) J. Zhang et al.   Respiratory Care

Sputum-to-serum hydrogen sulfide ratio in COPD

(2014) Junpei Saito et al.   THORAX

Antioxidant Effects of Hydrogen Sulfide on Left Ventricular Remodeling in Smoking Rats Are Mediated via PI3K/Akt-Dependent Activation of Nrf2

(2014) Xiang Zhou et al.   TOXICOLOGICAL SCIENCES

The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress

(2013) Tao Zeng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protective Effects of Hydrogen Sulfide Against Chronic Alcohol Intake-Induced Left Ventricular Remodeling in Rats

(2013) Xiang Zhou et al.   CARDIOVASCULAR DRUGS AND THERAPY

Polysulfide exerts a protective effect against cytotoxicity caused byt-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells

(2013) Shin Koike et al.   FEBS LETTERS

Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia

(2012) Utpal Sen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Sodium hydrogen sulfide inhibits nicotine and lipopolysaccharide-induced osteoclastic differentiation and reversed osteoblastic differentiation in human periodontal ligament cells

(2012) Sun-Kyung Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Hydrogen Sulfide Ameliorates Tobacco Smoke-Induced Oxidative Stress and Emphysema in Mice

(2011) Weihong Han et al.   ANTIOXIDANTS & REDOX SIGNALING

Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1

(2011) Tao Zeng et al.   FOOD AND CHEMICAL TOXICOLOGY

Cigarette Smoking and Inflammation

(2011) J. Lee et al.   JOURNAL OF DENTAL RESEARCH

The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat

(2010) Martin J. Ronis et al.   ALCOHOL

Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung

(2010) Ya-Hong Chen et al.   CYTOKINE

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat

(2009) Aracely Evangelina Chávez-Piña et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hydrogen Sulfide Prevents Ethanol-Induced Gastric Damage in Mice: Role of ATP-Sensitive Potassium Channels and Capsaicin-Sensitive Primary Afferent Neurons

(2009) J. V. R. Medeiros et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance

(2008) Chris E. Cooper et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice

(2008) Tao Zeng et al.   TOXICOLOGY