Article
Respiratory System
Nicola P. Bondonno, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Daniel Bech Rasmussen, Cecilie Kyro, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Anne Tjonneland, Kim Overvad, Anja Olsen, Jonathan M. Hodgson
Summary: This study found that higher flavonoid intakes were associated with a lower risk of COPD. Additionally, higher flavonoid intakes appeared to mitigate the increased risk of COPD associated with smoking. However, smoking cessation remains the highest priority in preventing COPD.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Automation & Control Systems
Nicola Vassena
Summary: Perturbations are common in metabolism, and sensitivity analysis is a key tool to understand and control their impact on metabolic networks. This paper adopts a structural approach based on network stoichiometry to investigate the network's response to perturbations in reaction rates and metabolite concentrations at equilibrium. The study focuses on the sign of the responses and identifies the subnetworks that play a major role in sign description.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Biochemistry & Molecular Biology
Theodora Panagaki, Laszlo Pecze, Elisa B. Randi, Anni I. Nieminen, Csaba Szabo
Summary: Increased H2S generation in Down syndrome (DS) promotes pseudohypoxia and contributes to cellular metabolic dysfunction by causing a shift from oxidative phosphorylation to glycolysis.
Article
Cell Biology
Abigail Hohoayi, Aaron O. Antwi, Veronica Amoah, Newman Osafo, Paul P. O. Sampene, George Ainooson
Summary: This study evaluated the effect of stigmasterol (STIG) and stigmasterol-dexamethasone combination (STIG+DEX) in steroid-resistant asthma. The findings showed that STIG alone had no effect on inflammatory features, but caused some changes in the molecular events related to steroid-resistant asthma. However, the combination of STIG+DEX significantly modulated inflammatory features and protected against lung tissue destruction.
MEDIATORS OF INFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Valentina Guarnotta, Roberta Amodei, Carla Giordano
Summary: Adrenal insufficiency (AI) is associated with higher mortality and morbidity compared with the general population. Conventional replacement steroid therapy leads to increased metabolic comorbidities, while dual-release hydrocortisone offers a decreased risk and mimics the physiological profile of cortisol. The reduced daily steroid exposure of dual-release hydrocortisone spares the clock genes involved in metabolic pathways, maintaining the normal physiological circadian rhythm of endogenous cortisol. This narrative review focuses on the metabolic comorbidities of AI due to steroid replacement therapy, evaluating the effects of conventional and novel drugs with attention to chronopharmacology.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Sandra Leibold, Amrutha Bagivalu Lakshminarasimha, Felix Gremse, Matthias Hammerschmidt, Maximilian Michel
Summary: Obesity and metabolic syndrome are global concerns. Zebrafish have been used to study the biology and etiology of obesity. This study found that long-term obesity in zebrafish leads to metabolic abnormalities similar to mammals, but without glucose dysregulation. Early caloric restriction in zebrafish did not exacerbate metabolic syndrome, while later exposure to the obesogenic environment did not completely reverse the effects of caloric restriction.
Article
Cell Biology
Edgar Sanchez-Ramirez, Thi Phuong Lien Ung, Alejandro Alarcon del Carmen, Ximena del Toro-Rios, Guadalupe R. Fajardo-Orduna, Lilia G. Noriega, Victor A. Cortes-Morales, Armando R. Tovar, Juan Jose Montesinos, Ricardo Orozco-Solis, Chiara Stringari, Lorena Aguilar-Arnal
Summary: This study reveals the role of NAD(+) and SIRT1 in adipogenic differentiation, demonstrating that NAD(+) inhibits adipocyte commitment while SIRT1 is essential for terminal differentiation of pre-adipocytes and regulates subcellular compartmentalization of redox metabolism.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Respiratory System
Nicholas B. Tiller, April Kinninger, Asghar Abbasi, Richard Casaburi, Harry B. Rossiter, Matthew J. Budoff, Alessandra Adami
Summary: The study found that COPD patients had higher CAC, lower muscle oxidative capacity, and lower self-reported PA levels compared to controls. Multivariate analysis revealed a significant negative association between CAC and the difficulty score of PA. These findings suggest that COPD patients with elevated CAC may experience greater difficulty in performing daily activities.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Cell Biology
Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R. R. Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F. F. Ochsenbein, Thomas M. M. Marti, Gregor J. J. Kocher, Ralph A. A. Schmid, Patrick Dorn, Ren-Wang Peng
Summary: Malignant pleural mesothelioma (MPM) is a lethal malignancy caused by asbestos exposure. In this study, we found that the hyperactive MAPK pathway is a molecular driver of MPM, and blocking this pathway induces cell apoptosis. Additionally, the MAPK pathway cooperates with PARP1 to regulate ROS levels, and combining MEK inhibitors with PARP inhibitors enhances cell apoptosis.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Muraly Puttabyatappa, Joseph N. Ciarelli, Adam G. Chatoff, Vasantha Padmanabhan
Summary: The study suggests that prenatal testosterone excess may lead to insulin resistance, mainly due to mitochondrial and endoplasmic reticulum dysfunction in muscle. Additionally, fibrosis and premature senescence may occur in the liver, while changes in mitochondrial function and ER stress in different adipose tissues are depot-specific.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Physiology
Steven K. Malin, Mary-Margaret E. Remchak, Anthony J. Smith, Tristan J. Ragland, Emily M. Heiston, Udeyvir Cheema
Summary: The study found that individuals with early chronotypes who have metabolic syndrome tend to utilize more fat during rest and exercise compared to those with late chronotypes. This difference in fuel selection is associated with higher physical activity levels throughout the day for early chronotypes. Additionally, the findings suggest that greater fat utilization in early chronotypes is related to non-oxidative glucose disposal and may influence their risk for type 2 diabetes.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Md Shahjalal Hossain Khan, Marleigh Hefner, Arubala Reddy, Nikhil V. V. Dhurandhar, Vijay Hegde
Summary: This study suggests that improving glycemic control and steatosis may attenuate obesity-related cognitive decline. The adenoviral protein E4orf1 is shown to have the potential to address this issue, but further investigations are needed.
NUTRITION & DIABETES
(2023)
Review
Endocrinology & Metabolism
Ankit Gupta, Abdulsatar Jamal, Dina A. Jamil, Hayder A. Al-Aubaidy
Summary: This review highlights the potential benefits of citrus bioflavonoids in patients with type 2 diabetes mellitus and its metabolic complications. The results suggest that citrus bioflavonoids may reduce oxidative stress levels and have a positive impact on markers of diabetes. These findings indicate that citrus bioflavonoids may be a useful complementary therapy for patients with diabetes.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Hassan Mustafa Arif, Zhongming Qian, Rui Wang
Summary: This article summarizes the significance of the interplay between hydrogen sulfide (H2S) and iron in cellular fate and wellness. The abnormal metabolisms of both iron and H2S are associated with various diseases. Future studies should evaluate the physiological and pathophysiological importance of H2S and iron together, and expand research to other fields where the interaction between H2S and iron has not been well studied.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell Biology
Eden T. Wondimu, Quanxi Zhang, Zhuping Jin, Ming Fu, Roberta Torregrossa, Matthew Whiteman, Guangdong Yang, Lingyun Wu, Rui Wang
Summary: Hydrogen sulfide (H2S) promotes glycolysis-mediated energy production in mitochondria-free mouse red blood cells by regulating endogenous H2S production through the enzyme MST. Both exogenous H2S and endogenous H2S derived from MST stimulate ATP production through glycolysis. The effects of H2S on ATP levels and cell viability are concentration-dependent, with low concentrations increasing ATP levels but decreasing cell viability, and high concentrations lowering ATP levels but prolonging cell viability. H2S may offer a cytoprotective effect in mammalian red blood cells to maintain oxygen-independent energy production.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Michael Groeger, Melanie Hogg, Essam Abdelsalam, Sandra Kress, Andrea Hoffmann, Bettina Stahl, Veronique Saub, Nicole Denoix, Oscar McCook, Enrico Calzia, Eva-Maria Wolfschmitt, Ulrich Wachter, Josef A. Vogt, Rui Wang, Peter Radermacher, Tamara Merz, Benedikt L. Nussbaum
Summary: This study investigated the effects of sodium thiosulfate (Na2S2O3) administration during resuscitation from trauma-and-hemorrhage in mice under conditions of whole body cystathionine gamma-lyase (CSE) deficit. The results showed that Na2S2O3 exerted beneficial effects in terms of organ protection and anti-inflammatory properties, improving lung function, reducing norepinephrine requirements, increasing urine output, and regulating inflammatory response and oxidative stress in the kidney tissue. These findings suggest that Na2S2O3 could be a potential therapeutic option in the context of impaired CSE activity and/or reduced endogenous H2S availability.
Article
Pharmacology & Pharmacy
Yan Yu, Jing-Jing Li, Xiao-Qian He, Zi-Ying Lai, Rui Hao, Yu Qi, Dong-Qing Cao, Ming Fu, Hong Ma, Qiu-Chen Xie, Mu Sun, Zhi-Li Huang, Ling-Jing Jin, Hui-hui Sun, Ning Lu, Rui Wang, Wing-Ho Yung, Ying Huang
Summary: This study found that dysfunction of the 5-HT3R affects synaptic plasticity between hippocampal neurons, leading to impairment in spatial memory. This effect is mediated through the CB1R-GABA(A) pathway on the 5-HT3R.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Huiying Huang, Siqing Zhu, Yuemei Han, Dong Liu, Sihao Liu, Duoduo Lu, Rui Wang, Quankui Lin
Summary: Posterior capsule opacification (PCO) is a common complication in cataract surgery, primarily caused by residual lens epithelial cells. Despite advancements in IOL surface modification techniques for PCO prevention, issues such as long-term efficacy and intraocular biocompatibility remain. This study presents a novel IOL modification approach with enzymes for efficient PCO suppression without toxic drugs, showcasing promising results in in vitro and in vivo evaluations.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Jiayi Xia, Yuemei Han, Liangliang Shen, Rui Wang, Shimin Wen, Siqing Zhu, Quankui Lin
Summary: A photo-responsive drug release coating was successfully constructed on IOL surface to inhibit PCO incidence. In vitro assay showed excellent anti-adhesion and anti-proliferation effects of the coating on LECs under irradiation, with photo-controlled drug release achieved by adjusting irradiation intensity and time.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Medicinal
Dongping Li, Kexin Jiang, Dan Teng, Zengrui Wu, Weihua Li, Yun Tang, Rui Wang, Guixia Liu
Summary: This study describes the discovery of novel potent agonists or inverse agonist of ERR alpha using a combined virtual screening approach. These compounds showed activity against ERR alpha in biological investigations and have different chemical structures from known agonists. The study also demonstrates the successful application of molecular dynamics-guided virtual screening in identifying ERR alpha agonists.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Medicine, General & Internal
Michael Groger, Melanie Hogg, Essam Abdelsalam, Sandra Kress, Andrea Hoffmann, Bettina Stahl, Enrico Calzia, Ulrich Wachter, Josef A. Vogt, Rui Wang, Tamara Merz, Peter Radermacher, Oscar McCook
Summary: This study investigated the therapeutic effects of sodium thiosulfate (STS) in mice with type 1 diabetes mellitus (DMT1). The results showed that STS did not have a therapeutic effect in DMT1 mice, possibly due to the more severe circulatory shock caused by DMT1.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Zheling Feng, Jiali Chen, Cheng Chen, Lu Feng, Rui Wang, Jianzhong Zhu, Ruohan Lou, Jia Liu, Yang Ye, Ligen Lin
Summary: This study discovered that polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia cambogia have lipid-lowering effects and can induce browning of adipocytes. Among them, guttiferone J (GOJ) is the most potent inducer of browning, which activates the deacetylase SIRT3 to enhance mitochondrial biogenesis and thermogenesis. In high-fat diet-induced obese mice, GOJ protected against obesity and related disorders by promoting browning of adipose tissue.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Peripheral Vascular Disease
Rui Wang
Summary: Hypertension is a complex health challenge with multiple causes, while hydrogen sulfide (H2S) serves as a multifunctional gasotransmitter. Animal studies conducted 15 years ago have established the critical role of endogenous H2S deficiency in hypertension development, leading to further investigations into its cardiovascular effects and underlying molecular and cellular mechanisms. We are also beginning to understand the involvement of altered H2S metabolism in human hypertension. This article aims to provide a comprehensive understanding of H2S's roles in hypertension development in both animals and humans, and review H2S-based antihypertension therapeutic strategies.
Article
Biochemistry & Molecular Biology
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike
Summary: Reactive sulfur species, such as cysteine hydropersulfide and glutathione persulfide, are produced abundantly in both prokaryotes and eukaryotes, including mammals. Cysteinyl-tRNA synthetase (CARS) has been identified as a new cysteine persulfide synthase (CPERS) responsible for the production of most reactive persulfides. However, the contribution of other enzymes, such as 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine beta-synthase (CBS), and cystathionine gamma-lyase (CSE), to reactive persulfide production is still debated. In this study, the authors used sulfur metabolome analysis to demonstrate that 3-MST, CBS, and CSE are not major sources of reactive persulfides in mammals, and CARS/CPERS is the principal enzyme involved.
Article
Chemistry, Medicinal
Rui Wang, Zhecheng Zhou, Xiaonan Wu, Xin Jiang, Linlin Zhuo, Mingzhe Liu, Hao Li, Xiangzheng Fu, Xiaojun Yao
Summary: This study proposes a feature-correction-based model for plant SSP recognition, called SE-SSP. The model uses Transformer encoders and a feature correction module to improve prediction performance, and applies contrastive learning strategy to mitigate the problem of sparse samples. Experimental results demonstrate the excellent performance of the proposed model.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Chemistry, Multidisciplinary
Tayebeh Amanpour, Rui Wang
Summary: Sulfenamides are organosulfur compounds that have a nitrogen-sulfur single bond structure. They play important roles in polymers used in various fields such as medicine, agrochemicals, veterinary medications, and environmental studies. This review focuses on the chemical reactions leading to sulfenamide production and their applications in cell biology and biochemistry.
JOURNAL OF SULFUR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Min Chen, Rui Wang, Qing-Xuan Ren, Bin Li, Ping Li, Hua Yang, Wen Gao
Summary: In this study, an online PB reaction coupled with SFC-MS was established to analyze C--C bonds in UFAs. The setup allowed for rapid capture of both prototype and product ions of FAs at the same retention time, significantly enhancing the accuracy of lipid identification. Additionally, a high C--C bond conversion rate was achieved, and the method demonstrated excellent relative quantification abilities.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Zhaoyu Ran, Yaru Zhang, Zhen Luo, Yujie Zhu, Mingti Wang, Rui Wang, Jing Fu, Qing Shao, Hui Quan, Hao Yuan, Jun Hu, Jinliang He, Qi Li
Summary: This study demonstrates the improved dielectric and capacitive performance of a polypropylene composite by grafting a molecular semiconductor onto polypropylene chains. The grafted molecular semiconductor introduces deep traps to inhibit the migration of high-energy charge carriers and enhances the regulation effect by positively influencing the microstructure of the polymer. The composite exhibits reduced leakage current, dielectric loss, electric field distortion, and increased breakdown strength at high temperatures.
MATERIALS TODAY ENERGY
(2023)
