Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer

TGF-β induces ST2 and programs ILC2 development

(2020) Li Wang et al.   Nature Communications

COUP-TFII in Health and Disease

(2020) Simone Polvani et al.   Cells

Association of body mass index with colorectal cancer risk by genome-wide variants

(2020) Peter T Campbell et al.   JNCI-Journal of the National Cancer Institute

The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer

(2019) Francesco Dituri et al.   Cells

Mongersen (GED-0301) for Active Crohnʼs Disease

(2019) Bruce E. Sands et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn’s Disease

(2018) Brian G. Feagan et al.   GASTROENTEROLOGY

Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice

(2018) Roberta Izzo et al.   INFLAMMATORY BOWEL DISEASES

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

(2018) Laia Caja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells

(2018) Rui Zhou et al.   Oncology Letters

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

(2017) Barbara Jung et al.   GASTROENTEROLOGY

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases

(2017) Evangelia Pardali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets

(2017) Difeng Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A low-frequency variant in SMAD7 modulates TGF-β signaling and confers risk for colorectal cancer in Chinese population

(2017) Jiaoyuan Li et al.   MOLECULAR CARCINOGENESIS

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death

(2017) Veronica De Simone et al.   Cell Death & Disease

Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts

(2016) Guangzao Li et al.   EXPERIMENTAL CELL RESEARCH

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands

(2016) Victor S. Cortez et al.   IMMUNITY

Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis

(2016) Silvia Speca et al.   INFLAMMATORY BOWEL DISEASES

TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota

(2016) Sozaburo Ihara et al.   JOURNAL OF IMMUNOLOGY

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

(2016) Yongsheng Huang et al.   Oncotarget

Biomarkers of intestinal fibrosis – one step towards clinical trials for stricturing inflammatory bowel disease

(2016) Paolo Giuffrida et al.   United European Gastroenterology Journal

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Suppressing TGF  Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

(2015) H. Oshima et al.   CANCER RESEARCH

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

(2015) Jason L. Kubinak et al.   Cell Host & Microbe

Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2

(2015) Noel F.C.C. de Miranda et al.   GASTROENTEROLOGY

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells

(2015) Ikkou Kashiwagi et al.   IMMUNITY

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

(2015) Darren Ruane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells

(2014) Angelamaria Rizzo et al.   CARCINOGENESIS

The Molecular Pathogenesis of Colorectal Cancer and Its Potential Application to Colorectal Cancer Screening

(2014) William M. Grady et al.   DIGESTIVE DISEASES AND SCIENCES

Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK

(2014) Philip W. Voorneveld et al.   GASTROENTEROLOGY

A functional role for Smad7 in sustaining colon cancer cell growth and survival

(2014) C Stolfi et al.   Cell Death & Disease

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Essentials of Th17 cell commitment and plasticity

(2013) P. Muranski et al.   BLOOD

The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

(2013) Paolo Biancheri et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Organized proteomic heterogeneity in colorectal cancer liver metastases and implications for therapies

(2013) Andrei Turtoi et al.   HEPATOLOGY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

The Dual Role of Smad7 in the Control of Cancer Growth and Metastasis

(2013) Carmine Stolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-Beta Suppresses VEGFA-Mediated Angiogenesis in Colon Cancer Metastasis

(2013) Liying Geng et al.   PLoS One

A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease

(2012) F. Zorzi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

(2012) N. I. Fleming et al.   CANCER RESEARCH

Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies

(2012) Tine Jess et al.   Clinical Gastroenterology and Hepatology

TGF-β1 Signalling, Connecting Aberrant Inflammation and Colorectal Tumorigenesis

(2012) Victoria R. Skeen et al.   CURRENT PHARMACEUTICAL DESIGN

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

(2012) Giovanni Monteleone et al.   MOLECULAR THERAPY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

(2011) Reena Rani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin

(2010) Manuela Pinheiro et al.   BMC CANCER

Increased Risk of Colon Cancer Associated with a Genetic Polymorphism of SMAD7

(2010) M. L. Slattery et al.   CANCER RESEARCH

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

Development and functional specialization of CD103+dendritic cells

(2010) Maria-Luisa del Rio et al.   IMMUNOLOGICAL REVIEWS

Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis

(2010) Sarah N. Flier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive assessment of variation at the transforming growth factor β type 1 receptor locus and colorectal cancer predisposition

(2010) Luis G. Carvajal-Carmona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Association of common genetic variants in SMAD7 and risk of colon cancer

(2009) C. L. Thompson et al.   CARCINOGENESIS

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

(2009) Patty Trobridge et al.   GASTROENTEROLOGY

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

(2009) Fatima Haggar et al.   Clinics in Colon and Rectal Surgery

Smad7 induces hepatic metastasis in colorectal cancer

(2008) S K Halder et al.   BRITISH JOURNAL OF CANCER

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

(2008) Albert Tenesa et al.   NATURE GENETICS

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY