Acrolein: A Potential Mediator of Oxidative Damage in Diabetic Retinopathy

Diabetes-Induced Inflammation and Vascular Alterations in the Goto–Kakizaki Rat Retina

(2020) Soumaya Hachana et al.   CURRENT EYE RESEARCH

Omega-3 Fatty Acid and its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy

(2020) Ayana Suzumura et al.   DIABETES

Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?

(2020) Esraa Shosha et al.   Journal of Clinical Medicine

Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice

(2020) Fang Liu et al.   Journal of Clinical Medicine

Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice

(2020) Xun Wu et al.   Neuroscience Bulletin

Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy

(2020) Beatriz Martins et al.   Antioxidants

An Intensified Acrolein Exposure Can Affect Memory and Cognition in Rat

(2020) Mona Khoramjouy et al.   NEUROTOXICITY RESEARCH

Roles of circular RNAs in diabetic complications: From molecular mechanisms to therapeutic potential

(2020) Ji-Ru Zhang et al.   GENE

Effect of Fenofibrate on the Expression of Inflammatory Mediators in a Diabetic Rat Model

(2019) Po-Ting Yeh et al.   CURRENT EYE RESEARCH

Identification of acrolein metabolites in human buccal cells, blood, and urine after consumption of commercial fried food

(2019) Tse‐Wen Wang et al.   Food Science & Nutrition

Spermine oxidase: A Promising Therapeutic Target for Neurodegeneration in Diabetic Retinopathy

(2019) S. Priya Narayanan et al.   PHARMACOLOGICAL RESEARCH

Apocynin ameliorates diabetic retinopathy in rats: Involvement of TLR4/NF-κB signaling pathway

(2019) Yixin Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

(2019) Olvera-Montaño Cecilia et al.   Journal of Diabetes Research

Evaluation of the andrographolides role and its indoleamine 2,3-dioxygenase inhibitory potential and attendant molecular mechanism against STZ-induced diabetic rats

(2019) Munipally Praveen Kumar et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease

(2018) Abeje Ambaw et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Incidence and progression of diabetic retinopathy: a systematic review

(2018) Charumathi Sabanayagam et al.   Lancet Diabetes & Endocrinology

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

(2018) Melissa Tully et al.   Frontiers in Neurology

Early and localized retinal dysfunction in patients with type 1 diabetes mellitus studied by multifocal electroretinogram

(2018) Lucia Ziccardi et al.   ACTA DIABETOLOGICA

Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients

(2018) Vatsalya Vatsalya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine

(2018) Rosemary E. McDowell et al.   DIABETOLOGIA

The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy

(2018) Meng-Yu Wu et al.   Oxidative Medicine and Cellular Longevity

Aldehyde toxicity and metabolism: The role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis

(2018) Amaj Ahmed Laskar et al.   DRUG METABOLISM REVIEWS

Polyamine catabolism and oxidative damage

(2018) Tracy Murray Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets

(2018) Harshini Chakravarthy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury

(2018) Rachel L. Hill et al.   JOURNAL OF NEUROTRAUMA

Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds

(2017) Bebiana C. Sousa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phenelzine Protects Brain Mitochondrial FunctionIn VitroandIn Vivofollowing Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection

(2017) John E. Cebak et al.   JOURNAL OF NEUROTRAUMA

Müller cells and diabetic retinopathy

(2017) Brandon A. Coughlin et al.   VISION RESEARCH

Protective Effects of Hesperidin (Citrus Flavonone) on High Glucose Induced Oxidative Stress and Apoptosis in a Cellular Model for Diabetic Retinopathy

(2017) Wayne Liu et al.   Nutrients

Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression

(2016) Wang-Sen Qin et al.   Archives of Medical Science

Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging

(2016) Takeshi Uemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

(2016) C. Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders

(2016) Philip C. Burcham   CHEMICAL RESEARCH IN TOXICOLOGY

Localization of Acrolein-Lysine Adduct in Fibrovascular Tissues of Proliferative Diabetic Retinopathy

(2016) Yoko Dong et al.   CURRENT EYE RESEARCH

The neurovascular unit and the pathophysiologic basis of diabetic retinopathy

(2016) Thomas W. Gardner et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Decrease in acrolein toxicity based on the decline of polyamine oxidases

(2016) Takeshi Uemura et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Emerging Roles of Transforming Growth Factor β Signaling in Diabetic Retinopathy

(2016) Sarah E. Wheeler et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diabetes and increased lipid peroxidation are associated with systemic inflammation even in well-controlled patients

(2016) Alliny de Souza Bastos et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury

(2016) Zhe Chen et al.   JOURNAL OF NEUROCHEMISTRY

p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy

(2016) P. F. Barcelona et al.   JOURNAL OF NEUROSCIENCE

Uremic toxins: some thoughts on acrolein and spermine

(2016) Kunal K. Sindhu   RENAL FAILURE

Diabetes-induced oxidative stress in the vitreous humor

(2016) Zsuzsanna Géhl et al.   Redox Biology

A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody

(2016) Masayuki Takamatsu et al.   Scientific Reports

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Evaluation of dementia by acrolein, amyloid-β and creatinine

(2015) Kazuei Igarashi et al.   CLINICA CHIMICA ACTA

Mutual enhancement between high-mobility group box-1 and NADPH oxidase-derived reactive oxygen species mediates diabetes-induced upregulation of retinal apoptotic markers

(2015) Ghulam Mohammad et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Acrolein induced both pulmonary inflammation and the death of lung epithelial cells

(2014) Yang Sun et al.   TOXICOLOGY LETTERS

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

(2014) S P Narayanan et al.   Cell Death & Disease

Acrolein Exposure Is Associated With Increased Cardiovascular Disease Risk

(2014) Natasha DeJarnett et al.   Journal of the American Heart Association

Elevated protein carbonyl and HIF-1α levels in eyes with proliferative diabetic retinopathy

(2013) Sirpa Loukovaara et al.   ACTA OPHTHALMOLOGICA

Mitochondria-Targeted Antioxidant Peptide SS31 Protects the Retinas of Diabetic Rats

(2013) J. Huang et al.   CURRENT MOLECULAR MEDICINE

New Insights in the Pathogenesis of Multiple Sclerosis—Role of Acrolein in Neuronal and Myelin Damage

(2013) Melissa Tully et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathophysiological relevance of aldehydic protein modifications

(2013) Neven Zarkovic et al.   Journal of Proteomics

Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity

(2013) Yuan Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interaction of aldehydes derived from lipid peroxidation and membrane proteins

(2013) Stefania Pizzimenti et al.   Frontiers in Physiology

Protein Carbonylation and Aggregation Precede Neuronal Apoptosis Induced by Partial Glutathione Depletion

(2012) Anushka Dasgupta et al.   ASN Neuro

Protein Carbonylation in a Murine Model for Early Alcoholic Liver Disease

(2012) James J. Galligan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Differences in Susceptibility to Inactivation of Human Aldehyde Dehydrogenases by Lipid Peroxidation Byproducts

(2012) Belem Yoval-Sánchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Possible Role of Acrolein in Diabetic Retinopathy: Involvement of a VEGF/TGFβ Signaling Pathway of the Retinal Pigment Epithelium in Hyperglycemia

(2012) Jeffery Grigsby et al.   CURRENT EYE RESEARCH

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE)

(2011) Travis Musgrave et al.   BRAIN BEHAVIOR AND IMMUNITY

Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation

(2011) Ngome L. Makia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-inflammatory therapy for diabetic retinopathy

(2011) Wenbo Zhang et al.   Immunotherapy

Acrolein-mediated injury in nervous system trauma and diseases

(2011) Riyi Shi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase

(2011) Daniel J. Conklin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Acrolein scavengers: Reactivity, mechanism and impact on health

(2011) Qin Zhu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Toxicology and risk assessment of acrolein in food

(2011) Klaus Abraham et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Brain infarction correlates more closely with acrolein than with reactive oxygen species

(2010) Ryotaro Saiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products

(2010) T. M. Curtis et al.   DIABETOLOGIA

α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells

(2010) Zhihui Feng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus?

(2010) G. Bjelakovic et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse

(2010) G. Leung et al.   NEUROSCIENCE

Heme oxygenase-1 in neovascularisation: A diabetic perspective

(2010) Anna Grochot-Przeczek et al.   THROMBOSIS AND HAEMOSTASIS

Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

(2010) Hille W. van Dijk et al.   VISION RESEARCH

Potential Role of Acrolein in Neurodegeneration and in Alzheimers Disease

(2010) Dang Thanh Nam et al.   Current Molecular Pharmacology

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

Vascular dysfunction in retinopathy—An emerging role for arginase

(2009) Ruth B. Caldwell et al.   BRAIN RESEARCH BULLETIN

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Polyamine Catabolism Is Enhanced after Traumatic Brain Injury

(2009) Kamyar Zahedi et al.   JOURNAL OF NEUROTRAUMA

Intense Correlation Between Brain Infarction and Protein-Conjugated Acrolein

(2009) Ryotaro Saiki et al.   STROKE

Acrolein consumption induces systemic dyslipidemia and lipoprotein modification

(2009) Daniel J. Conklin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acrolein Induces Inflammatory Response Underlying Endothelial Dysfunction

(2008) Yong Seek Park et al.   Annals of the New York Academy of Sciences

Acrolein, IL-6 and CRP as markers of silent brain infarction

(2008) Madoka Yoshida et al.   ATHEROSCLEROSIS

Acrolein toxicity: Comparison with reactive oxygen species

(2008) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The change of oxidative stress products in diabetes mellitus and diabetic retinopathy

(2008) H.-Z. Pan et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Evaluation of N ε-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy

(2008) X. Zhang et al.   DIABETOLOGIA

Retinal ganglion cells in diabetes

(2008) Timothy S. Kern et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXII

(2008) Ronald Klein et al.   OPHTHALMOLOGY

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY