Article
Orthopedics
Seth A. Herr, Sarah Malek, Mark C. Rochat, George E. Moore, Jeff C. Ko, Riyi Shi
Summary: This study confirmed the presence of acrolein in the synovial fluid of dogs with osteoarthritis. Freezing synovial fluid for up to 5 years did not significantly affect the detection of acrolein-lysine adduct and MMP2 in the samples.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Nutrition & Dietetics
Qingzheng Kang, Haiyu Dai, Suwei Jiang, Li Yu
Summary: AGEs play important pathogenic roles in the development of diabetic retinopathy, including metabolic abnormalities, oxidative stress, and cytopathic effects. The interaction between AGEs and RAGE leads to various pathological alterations in retinal cells. Targeting disorders associated with AGEs and exploring the use of antioxidant phytochemicals as therapeutic strategies show potential for the treatment of diabetic retinopathy.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Johanna Rankenberg, Stefan Rakete, Brandie D. Wagner, Jennifer L. Patnaik, Christian Henning, Anne Lynch, Marcus A. Glomb, Ram H. Nagaraj
Summary: The levels of AGEs in human lens capsules during cataract surgery were found to be similar between diabetic and non-diabetic patients, except for significantly higher levels of glucosepane in diabetic patients, which may explain the similar incidence of posterior capsule opacification between the two groups.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Health Care Sciences & Services
Alejandra Planas, Olga Simo-Servat, Cristina Hernandez, Angel Ortiz-Zuniga, Joan Ramon Marsal, Jose R. Herance, Ignacio Ferreira-Gonzalez, Rafael Simo
Summary: This study aimed to evaluate whether diabetic retinopathy and accumulation of advanced glycation end-products can help identify high-risk cardiovascular events in patients with type 2 diabetes, and found that these factors were independent predictors of cardiovascular events. It is suggested that using these factors to screen patients for cardiovascular disease could lead to more personalized and cost-effective medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
H. Atli, E. Onalan, B. Yakar, T. Kaymaz, D. Duzenci, K. Karakulak, E. Donder, M. F. Gursu, R. Dayanan
Summary: This study investigated the role of serum asprosin level in the pathogenesis and differential diagnosis of diabetic retinopathy. It found that high levels of asprosin may be a risk factor for the development of diabetic complications, such as diabetic retinopathy.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lingwen Ying, Yun Shen, Yang Zhang, Yikun Wang, Yong Liu, Jun Yin, Yufei Wang, Jingrong Yin, Wei Zhu, Yuqian Bao, Jian Zhou
Summary: This study found a positive association between AGEs levels and diabetic retinopathy (DR), with higher AGEs associated with more severe DR. The predictive value of AGEs for DR was similar to that of glycated hemoglobin A(1c) (HbA(1c), but AGEs showed higher efficacy in early screening for vision-threatening DR (VTDR). Non-invasive measurement of skin AGEs may be a more suitable indicator for poor prognosis of hyperglycemia compared to HbA(1c).
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Agriculture, Multidisciplinary
Yaya Wang, Tianchang Zhang, Linqing Nie, Yan Zhang, Junping Wang, Qisijing Liu, Lu Dong, Yaozhong Hu, Bowei Zhang, Shuo Wang
Summary: This study found that heat-processed foods containing advanced lipoxidation end products (ALEs) can alter protein structure, decrease digestibility, and have adverse effects on liver function in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Saumik Biswas, Ali Coyle, Shali Chen, Miso Gostimir, John Gonder, Subrata Chakrabarti
Summary: With the increasing incidence of diabetes worldwide, diabetic retinopathy (DR) has become one of the leading causes of blindness in the working age population. Recent research has shown that long noncoding RNAs (lncRNAs) play a significant role in the development of DR. A serum-based PCR test using 9 lncRNAs has been developed as a potential diagnostic and prognostic tool for DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Sawako Hashimoto, Miho Yasuda, Kohta Fujiwara, Emi Ueda, Shun Nakamura, Yoichiro Hirakawa, Mayu Higashioka, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda
Summary: The prevalence and incidence of diabetic retinopathy (DR) among diabetic individuals in a Japanese community have significantly decreased over the past two decades.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Food Science & Technology
Peng Han, Qi Zhang, Xueyang Wang, Pengcheng Zhou, Shiyuan Dong, Fengchao Zha, Mingyong Zeng
Summary: This study compared the effects of different frying methods on the formation of AGEs in sturgeon patties and found that pan-fried and deep-fried patties had different levels of AGEs. Deep-fried patties had higher levels of CML compared to pan-fried patties, and this increase was positively correlated with frying time. The formation of AGEs during cooking was positively associated with temperature and amino groups, while negatively correlated with moisture content.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Ailsa J. McKay, Laura H. Gunn, Thirunavukkarasu Sathish, Eszter Vamos, Manjula Nugawela, Azeem Majeed, German Molina, Sobha Sivaprasad
Summary: This study found that attainment of key primary care indicators such as HbA1c and blood pressure was negatively associated with the incidence of diabetic retinopathy (DR) among patients with type 2 diabetes in England. However, cholesterol indicator attainment showed no association. Attainment of these indicators was also associated with a lower incidence of sight-threatening diabetic retinopathy (STDR).
Review
Cardiac & Cardiovascular Systems
Lakshmi Arivazhagan, Raquel Lopez-Diez, Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
Summary: Obesity and non-alcoholic fatty liver disease (NAFLD) are increasing globally. Consumption of high fat/high sugar diet leads to biochemical and molecular reactions that contribute to atherosclerosis and cardiovascular disease. RAGE/DIAPH1 signaling pathway plays a role in foam cell formation, cholesterol metabolism, and exacerbation of metabolic disorders and cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Taku Yamamoto, Satoru Kase, Miyuki Murata, Susumu Ishida
Summary: This study aimed to examine the levels of serum alpha B-crystallin and advanced glycation end-products (AGE) concentrations in proliferative diabetic retinopathy (PDR) patients. The results showed significantly higher serum AGE levels in PDR patients compared to patients with non-diabetic macular diseases, while no significant difference was observed in serum alpha B-crystallin levels.
BIOMEDICAL REPORTS
(2022)
Article
Immunology
Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Cheng-Hsun Lu, Yu-Min Kuo, Song-Chou Hsieh, Chia-Li Yu
Summary: Increased serum advanced glycation end products (AGEs) are commonly found in patients with Diabetes mellitus (DM), aging-related diseases, and immune-mediated diseases. The molecular basis of inflamm-aging related to AGEs remains unclear.
CLINICAL IMMUNOLOGY
(2023)
Article
Ophthalmology
Tine Van Bergen, Isabelle Etienne, Juan Jia, Jin-Ping Li, Israel Vlodavsky, Alan Stitt, Elke Vermassen, Jean H. M. Feyen
Summary: The study investigated the retinal morphology of heparanase knockout mice, finding that deficiency in heparanase leads to RPE folds, choroidal thickening, and retinal disorganization. The presence of discrete hyperfluorescent foci, a key characteristic of the human disease, was not observed in the mice. The toxicity observed in the presence of heparanase inhibitors is target-related, indicating that heparanase inhibition may not be a viable therapeutic intervention.
CURRENT EYE RESEARCH
(2021)
Review
Endocrinology & Metabolism
David A. Antonetti, Paolo S. Silva, Alan W. Stitt
Summary: Diabetes mellitus has detrimental effects on the signaling interactions of retinal cells, leading to vascular abnormalities and impaired neuronal function, but novel therapies have shown promise in improving visual outcomes. Research on diabetic retinopathy has uncovered potential new therapeutic avenues for treating this debilitating disease.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Jasenka Guduric-Fuchs, Edoardo Pedrini, Judith Lechner, Sarah E. J. Chambers, Christina L. O'Neill, Joana Mendes Lopes de Melo, Varun Pathak, Rachel H. Church, Stuart McKeown, James Bojdo, Kiran J. Mcloughlin, Alan W. Stitt, Reinhold J. Medina
Summary: miR-130a acts as a mediator in the hypoxic response of ECFCs, enhancing their angiogenic and vasoreparative abilities by coordinating the upregulation of VEGFR2/STAT3/HIF1 alpha axis through translational inhibition of Ddx6.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Mitsuru Arima, Shintaro Nakao, Yoshihiro Kaizu, Iori Wada, Muneo Yamaguchi, Kohta Fujiwara, Masato Akiyama, Alan W. Stitt, Koh-Hei Sonoda
Summary: Our study found that vascular permeability influences vascular flow density (FD)-correlated retinal sensitivity (RS) in diabetic retinopathy, suggesting that vascular hyperpermeability may inhibit RS reduction in the non-edematous ischemic diabetic retina.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Karis Little, Maria Llorian-Salvador, Sarah Scullion, Cristina Hernandez, Olga Simo-Servat, Angel del Marco, Esmeralda Bosma, Maria Vargas-Soria, Maria Jose Carranza-Naval, Tine Van Bergen, Silvia Galbiati, Ilaria Vigano, Clara Alice Musi, Reiner Schlingemann, Jean Feyen, Tiziana Borsello, Gianpaolo Zerbini, Ingeborg Klaassen, Monica Garcia-Alloza, Rafael Simo, Alan W. Stitt
Summary: Type 2 diabetes is associated with complications like diabetic retinopathy and cognitive decline, with chronic hyperglycemia and insulin resistance playing crucial roles. Understanding these common pathological mechanisms may help in identifying T2D patients at risk of cognitive decline.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Kevin Harkin, Josy Augustine, Alan W. Stitt, Heping Xu, Mei Chen
Summary: This study found that Wedelolactone (WD) can protect against N-methyl-N-nitrosourea (NMU) induced retinal neurodegeneration by suppressing the inflammasome-related pathway. The results showed that WD can attenuate the impairment of retinal function and structure caused by NMU and reduce the expression of inflammasome-related genes.
Review
Cell & Tissue Engineering
Judith Lechner, Reinhold J. Medina, Noemi Lois, Alan W. Stitt
Summary: Diabetic retinopathy, a complication of diabetes, is a leading cause of vision loss in working age adults. The loss of integrity of the retinal neurovascular unit is central to the disease pathogenesis. Current treatment options are limited to late-stages of the disease, and new treatments are needed to target early stages and prevent vision loss.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pediatrics
Jessica A. Omand, Xuedi Li, Charles D. G. Keown-Stoneman, Cornelia M. Borkhoff, Eric Duku, Gerald Lebovic, Jonathon L. Maguire, Muhammad M. Mamdani, Patricia C. Parkin, Caroline Reid-Westoby, Janis Randall Simpson, Mark S. Tremblay, Magdalena Janus, Catherine S. Birken
Summary: This study investigates the association between body weight in early childhood and school readiness in young children. Being classified as overweight or with obesity was found to be associated with poor school readiness in year 2 of kindergarten. Early interventions to promote healthy growth before school entry may help promote development and school readiness in young children.
Article
Medicine, General & Internal
Courtney A. South, Charles D. G. Keown-Stoneman, Catherine S. Birken, Vasanti S. Malik, Stanley H. Zlotkin, Jonathon L. Maguire
Summary: This study examined the association between underweight in the first 2 years of life and growth in later childhood, and found that underweight in the first 2 years is associated with lower zBMI and HAZ in later childhood.
Article
Endocrinology & Metabolism
Muneo Yamaguchi, Shintaro Nakao, Iori Wada, Tetsuya Matoba, Mitsuru Arima, Yoshihiro Kaizu, Mariko Shirane, Keijiro Ishikawa, Takahito Nakama, Yusuke Murakami, Masaharu Mizuochi, Wataru Shiraishi, Ryo Yamasaki, Toshio Hisatomi, Tatsuro Ishibashi, Masabumi Shibuya, Alan W. Stitt, Koh-Hei Sonoda
Summary: In this study, it was found that there is a significant increase in intraretinal hyperreflective foci (HRF) in diabetic retinopathy (DR). The proliferation of vitreous resident macrophages (VRMs) at the vitreoretinal interface (VRI) is driven by vascular endothelial growth factor (VEGF), leading to the formation of HRF lesions. Anti-VEGF therapy can reverse this phenomenon.
Article
Physiology
Pietro Maria Bertelli, Edoardo Pedrini, David Hughes, Shannon McDonnell, Varun Pathak, Elisa Peixoto, Jasenka Guduric-Fuchs, Alan W. Stitt, Reinhold J. Medina
Summary: Long-term exposure to 25 mM D-glucose accelerated the establishment of cellular senescence in human retinal microvascular endothelial cells, leading to decreased clonogenic capacity, diminished tubulogenicity, and impaired barrier function.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Michael O'Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincola, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis
Summary: Loss of retinal blood flow autoregulation is an early feature of diabetes and is associated with the downregulation of the TRPV2 channels on retinal vascular smooth muscle cells. A TRPV2 heterozygous rat model demonstrates lesions similar to those observed in diabetic retinopathy, supporting the hypothesis that autoregulatory deficits are involved in the pathogenesis of diabetic retinopathy.
Article
Oncology
Sophia Millington-Ward, Naomi Chadderton, Laura K. Finnegan, Iris J. M. Post, Matthew Carrigan, Tom Gardiner, Elisa Peixoto, Daniel Maloney, Marian M. Humphries, Alan Stitt, Thierry Leveillard, Pete Humphries, Paul F. Kenna, Arpad Palfi, G. Jane Farrar
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Josy Augustine, Sofia Pavlou, Kevin Harkin, Alan W. Stitt, Heping Xu, Mei Chen
Summary: Diabetic retinopathy (DR) leads to visual impairment and blindness due to dysfunction and inflammation of Mu'' ller cells. Interleukin-33 (IL-33) plays a crucial immunomodulatory role in DR, and its absence promotes inflammation, neurodegeneration, and decreased neurotrophin secretion.
DISEASE MODELS & MECHANISMS
(2023)
Article
Multidisciplinary Sciences
Sara G. Romeo, Ilaria Secco, Edoardo Schneider, Christina M. Reumiller, Celio X. C. Santos, Anna Zoccarato, Vishal Musale, Aman Pooni, Xiaoke Yin, Konstantinos Theofilatos, Silvia Cellone Trevelin, Lingfang Zeng, Giovanni E. Mann, Varun Pathak, Kevin Harkin, Alan W. Stitt, Reinhold J. Medina, Andriana Margariti, Manuel Mayr, Ajay M. Shah, Mauro Giacca, Anna Zampetaki
Summary: The microvasculature is critical for the delivery of oxygen and metabolites throughout tissues. In this study, human blood vessel organoids (BVOs) were used to show that CTGF is a critical paracrine regulator of microvascular integrity that can restore pericyte coverage and vessel structure.
NATURE COMMUNICATIONS
(2023)