Article
Agricultural Engineering
Zhi-Peng Wang, Pei-Kang Wang, Yan Ma, Jia-Xue Lin, Cheng-Long Wang, Yu-Xiang Zhao, Xin-Yue Zhang, Bei-Chen Huang, Shou-Geng Zhao, Lei Gao, Jing Jiang, Hai-Ying Wang, Wei Chen
Summary: The study demonstrated that the addition of Laminaria japonica hydrolysate (LPH) is a feasible and efficient strategy to promote fucoxanthin accumulation. In the LPH group, both fucoxanthin content and biomass were significantly increased.
BIORESOURCE TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xingyu Lu, Amila A. Dissanayake, Chuqiao Xiao, Jie Gao, Mouming Zhao, Muraleedharan G. Nair
Summary: In this study, five sterols were isolated and identified from Laminaria japonica, showing significant anti-inflammatory and antioxidant activities.
Review
Chemistry, Medicinal
Tsz-Ying Lau, Hiu-Yee Kwan
Summary: Breast cancer, a common and deadly cancer, can be effectively inhibited and prevented by fucoxanthin and its metabolites. Fucoxanthin also possesses anti-obesity effects and overcomes drug resistance. This review summarizes the anti-cancer mechanisms of fucoxanthin and provides novel strategies for its development as an anti-cancer therapeutic agent.
Review
Medicine, Research & Experimental
Lei Yin, Xiaotian Liu, Xuejun Shao, Tao Feng, Jun Xu, Qi Wang, Shenghao Hua
Summary: Exosomes play a crucial role in lung cancer metastasis by promoting various processes such as cell proliferation, angiogenesis, and immune evasion. They are also being explored as potential therapeutic drug carriers and predictive biomarkers for diagnosing, prognosis, and anti-tumor drug resistance in lung cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Yingzi Wu, Yuanhui Li, Wenhai Guo, Jie Liu, Weiguo Lao, Penghui Hu, Yiguang Lin, Hongjie Chen
Summary: The anticancer properties of Laminaria japonica peptides (LJPs) have never been studied. In this study, LJPs were extracted from fresh seaweed and their anti-liver cancer activity was explored. The results showed that LJP-1 induced apoptosis and G0/G1 arrest in liver cancer cells, inhibited tumor growth, and induced tumor cell apoptosis/necrosis. These findings suggest that LJP-1 has the potential to be a novel candidate for human liver cancer therapeutics.
Review
Pharmacology & Pharmacy
Xuan Liu, Yiqian Zhang, Xuyi Wu, Fuyan Xu, Hongbo Ma, Mengling Wu, Yong Xia
Summary: Ferroptosis is an iron-dependent form of cell death that is closely related to cancer progression, treatment response, and metastasis. Cancer cells can decrease their susceptibility to ferroptosis to resist anticancer therapy. Inducing ferroptosis can restore the sensitivity of drug-resistant cancer cells to standard treatments. Understanding the regulatory mechanisms and signaling pathways of ferroptosis can provide new insights to enhance the efficacy of anticancer drugs, overcome drug resistance, and inhibit cancer metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Jia Wang, Xue Dong, Dandan Li, Zhiyao Fang, Xianyao Wan, Jing Liu
Summary: This study found that fucoxanthin can inhibit lymphangiogenesis and lymph node metastasis in gastric cancer by regulating Ran expression and the importin beta/NF-kappa B/VEGF-C nuclear transport signaling pathway. These novel findings provide the basis for the research and development of novel treatments using traditional Chinese medicine in the treatment of lymph node metastasis, which has important theoretical significance and clinical value.
Article
Biochemistry & Molecular Biology
Chia-Lo Chang, Chi-Ruei Huang, Shu-Jyuan Chang, Chun-Chieh Wu, Hong-Hwa Chen, Chi-Wen Luo, Hon-Kan Yip
Summary: Colorectal cancer (CRC) is the most common cancer in Taiwan. CHD4 expression is elevated in CRC patients, impacting cell motility and drug sensitivity, and has the potential to serve as a prognostic biomarker for metastatic CRC patients and a target for drug development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Lifo Ruan, Jun Chen, Chuanchao Du, Huiru Lu, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Wenchu Lin, Zhifang Chai, Guangjun Nie, Yi Hu
Summary: The use of mitochondrial temperature-responsive drug delivery system can prevent drug efflux, facilitate drug accumulation and mitochondrial targeting in drug-resistant tumors. This technology enhances drug toxicity and reverses drug resistance, representing a significant advancement in combating cancer drug resistance.
BIOACTIVE MATERIALS
(2022)
Review
Oncology
Aysooda Hosseinzadeh, Faezeh Poursoleiman, Akram Naghdipour Biregani, Ahmad Esmailzadeh
Summary: Despite the complexity of cancer, natural flavonoids have shown potential as therapeutic agents by inhibiting metastasis and inducing cell death in cancer cells. This review discusses the dynamic relationship between metastasis, autophagy, anoikis, and the effects of flavonoids, suggesting that they can be effective in targeting both sensitive and resistant cancer cells.
CANCER CELL INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Hitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna, Vikas Jain
Summary: This article discusses the role of Nrf2 in the development of drug resistance, angiogenesis, cancer stem cell generation, and metastasis in breast cancer. Therapeutic strategies utilizing Nrf2 signaling cascades are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jinyi Liu, Liwen Ren, Sha Li, Wan Li, Xiangjin Zheng, Yihui Yang, Weiqi Fu, Jie Yi, Jinhua Wang, Guanhua Du
Summary: Exosomes are cell-derived nanovesicles that play essential roles in intercellular communication, cancer progression, and drug delivery. They have potential applications in cancer diagnosis, treatment, and research.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Agriculture, Multidisciplinary
Xue-Ying Li, Yu-Jing Wang, Shun Chen, Li-Hua Pan, Qiang-Ming Li, Jian-Ping Luo, Xue-Qiang Zha
Summary: The present study demonstrated that LJP61A significantly reduced the lesion burden in atherosclerotic mice and alleviated lipid deposition in Ox-LDL-stimulated macrophages. Moreover, LJP61A enhanced autophagy-mediated macrophage polarization, leading to reduced inflammation and atherosclerosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Oncology
Jinyong Fang, Jianjun Wang, Liangliang Yu, Wenxia Xu
Summary: The HOXC10 gene, a member of the HOX genes family, plays crucial roles in mammalian physiological processes, such as limb morphological development, limb regeneration, and lumbar motor neuron differentiation. Additionally, HOXC10 is associated with angiogenesis, fat metabolism, sex regulation, and various tumors. HOXC10 acts as an important transcription factor that activates oncogenic pathways by regulating target molecules and induces drug resistance in cancers. This review provides a comprehensive understanding of HOXC10 gene and its role in cancer, aiding in the discovery of new targets for cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)