Chronic lung diseases: prospects for regeneration and repair

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Applications of CRISPR systems in respiratory health: Entering a new ‘red pen’ era in genome editing

(2019) Colette Moses et al.   RESPIROLOGY

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

(2019) Peter J Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Non-Invasive Imaging Biomarker Identifies Small Airway Damage in Severe COPD

(2019) Dragos M Vasilescu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression

(2019) Li-Ming Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Regenerative pharmacology for COPD: breathing new life into old lungs

(2019) John-Poul Ng-Blichfeldt et al.   THORAX

Blood eosinophils as biomarkers of therapeutic response to chronic obstructive pulmonary disease: Still work in progress

(2019) Salvatore Fuschillo et al.   European Journal of Internal Medicine

Evolving Concepts in Chronic Obstructive Pulmonary Disease Blood-Based Biomarkers

(2019) Mario Cazzola et al.   Molecular Diagnosis & Therapy

COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside

(2019) Thibaut Capron et al.   European Respiratory Review

Incidence, Prevalence, and Survival of Patients with Idiopathic Pulmonary Fibrosis in the UK

(2018) Helen Strongman et al.   ADVANCES IN THERAPY

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

(2018) David W Waters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis

(2018) Milena S. Espindola et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease

(2018) Moumita Ghosh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease

(2018) Evelyn Tsantikos et al.   JOURNAL OF CLINICAL INVESTIGATION

Biomarkers in idiopathic pulmonary fibrosis

(2018) F. Drakopanagiotakis et al.   MATRIX BIOLOGY

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

(2018) Tsukasa Kadota et al.   MOLECULAR ASPECTS OF MEDICINE

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

(2018) Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

(2018) Jodie Birch et al.   PHARMACOLOGY & THERAPEUTICS

What can we learn about COPD from impulse oscillometry?

(2018) Brian J. Lipworth et al.   RESPIRATORY MEDICINE

Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells

(2018) Ulf Hedström et al.   Scientific Reports

Feasibility and challenges of using multiple breath washout in COPD

(2018) Alan S Bell et al.   International Journal of Chronic Obstructive Pulmonary Disease

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study

(2018) Amy Dressen et al.   Lancet Respiratory Medicine

Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study

(2018) Hyun-Kyoung Koo et al.   Lancet Respiratory Medicine

Basal-like Cells in the BAL Fluid: An Echo of Regenerative Crisis in IPF Lungs

(2018) Renat Shaykhiev   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Why an Aging Smoker Lung Develops IPF and Not COPD?

(2018) Moisés Selman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

BAL Cell Gene Expression is Indicative of Outcome and Airway Basal Cell Involvement in IPF

(2018) Antje Prasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COPD Pathogenesis

(2018) Jerome O. Cantor et al.   CHEST

MicroRNA-570 is a novel regulator of cellular senescence and inflammaging

(2018) Jonathan R. Baker et al.   FASEB JOURNAL

Focus on Idiopathic Pulmonary Fibrosis

(2018) Fernando J. Martinez et al.   CHEST

Initiating drug therapy in early stage chronic obstructive pulmonary disease

(2018) Robert M. Burkes et al.   CURRENT OPINION IN PULMONARY MEDICINE

Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo

(2018) Zahra Naseri et al.   International Journal of Nanomedicine

Diagnosis and Management of Rheumatoid Arthritis

(2018) Daniel Aletaha et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities

(2018) Piao Huang et al.   PHARMACOLOGY & THERAPEUTICS

Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF

(2018) Nicholas D Weatherley et al.   THORAX

Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

(2018) Laura A. Hancock et al.   Nature Communications

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantification of Lung PET Images: Challenges and Opportunities

(2017) Delphine L. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Distinct Roles of Wnt/β-Catenin Signaling in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2017) Juan Shi et al.   MEDIATORS OF INFLAMMATION

Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases

(2017) Wupeng Liao et al.   MOLECULES

Retinoic acid in developmental toxicology: Teratogen, morphogen and biomarker

(2017) Aldert H. Piersma et al.   REPRODUCTIVE TOXICOLOGY

Idiopathic Pulmonary Fibrosis: Molecular Endotypes of Fibrosis Stratifying Existing and Emerging Therapies

(2017) Daniele Magnini et al.   RESPIRATION

Therapeutic targets in idiopathic pulmonary fibrosis

(2017) Martin Kolb et al.   RESPIRATORY MEDICINE

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

(2017) David Lagares et al.   Science Translational Medicine

Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema

(2017) John-Poul Ng-Blichfeldt et al.   THORAX

‘WNT-er is coming’ : WNT signalling in chronic lung diseases

(2017) H A Baarsma et al.   THORAX

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

CT-Based Local Distribution Metric Improves Characterization of COPD

(2017) Benjamin A. Hoff et al.   Scientific Reports

Unmet needs in the treatment of idiopathic pulmonary fibrosis―insights from patient chart review in five European countries

(2017) Toby M. Maher et al.   BMC Pulmonary Medicine

Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway

(2017) Clare E. Weeden et al.   PLOS BIOLOGY

Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease

(2017) Marika Bajc et al.   International Journal of Chronic Obstructive Pulmonary Disease

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study

(2017) Toby M Maher et al.   Lancet Respiratory Medicine

Hepatocyte growth factor as a downstream mediator of vascular endothelial growth factor-dependent preservation of growth in the developing lung

(2016) Gregory Seedorf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

(2016) Alberico L. Catapano et al.   EUROPEAN HEART JOURNAL

Breathomics in the setting of asthma and chronic obstructive pulmonary disease

(2016) Lieuwe D. Bos et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

(2016) Hoeke A. Baarsma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole lung morphometry with 3D multiple b-value hyperpolarized gas MRI and compressed sensing

(2016) Ho-Fung Chan et al.   MAGNETIC RESONANCE IN MEDICINE

Combined pulmonary fibrosis and emphysema: The many aspects of a cohabitation contract

(2016) Andriana I. Papaioannou et al.   RESPIRATORY MEDICINE

Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis

(2016) Emer F. Cahill et al.   Stem Cells Translational Medicine

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

(2016) J. R. Baker et al.   Scientific Reports

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

(2015) Michael Zengerle et al.   ACS Chemical Biology

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

(2015) Hagai Yanai et al.   Aging-US

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Barriers to new drug development in respiratory disease

(2015) Peter J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

Pirfenidone for idiopathic pulmonary fibrosis: analysis of pooled data from three multinational phase 3 trials

(2015) Paul W. Noble et al.   EUROPEAN RESPIRATORY JOURNAL

Bronchioalveolar morphogenesis of human bronchial epithelial cells depending upon hepatocyte growth factor

(2015) Takashi Kato et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hyperpolarized Gas MR Imaging

(2015) Justus E. Roos et al.   Magnetic Resonance Imaging Clinics of North America

Validation of human small airway measurements using endobronchial optical coherence tomography

(2015) Yu Chen et al.   RESPIRATORY MEDICINE

Accelerated ageing of the lung in COPD: new concepts

(2015) Nicolas Mercado et al.   THORAX

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study

(2015) R Gisli Jenkins et al.   Lancet Respiratory Medicine

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis

(2014) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Grading obstructive lung disease using tomographic pulmonary scintigraphy in patients with chronic obstructive pulmonary disease (COPD) and long-term smokers

(2014) Marika Bajc et al.   ANNALS OF NUCLEAR MEDICINE

Simultaneous Assessment of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor in Epithelial Lining Fluid From Patients With COPD

(2014) Hiroshi Kanazawa et al.   CHEST

Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease

(2014) Huaying Wang et al.   Clinical Respiratory Journal

The Cyclooxygenase-2–Prostaglandin E2Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts

(2013) Maylis Dagouassat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Consensus statement for inert gas washout measurement using multiple- and single- breath tests

(2013) Paul D. Robinson et al.   EUROPEAN RESPIRATORY JOURNAL

Hepatocyte growth factor is an attractive target for the treatment of pulmonary fibrosis

(2013) Sushmita Chakraborty et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lessons from ECLIPSE: a review of COPD biomarkers

(2013) Rosa Faner et al.   THORAX

Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

(2013) Carla Calvi et al.   PLoS Genetics

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study

(2013) Imre Noth et al.   Lancet Respiratory Medicine

Defective Phagocytosis in Airways Disease

(2012) Louise E. Donnelly et al.   CHEST

Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor

(2012) Jan Stolk et al.   EUROPEAN RESPIRATORY JOURNAL

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

(2012) Isis E Fernandez et al.   LANCET

Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

(2012) Craig J Galbán et al.   NATURE MEDICINE

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

(2012) Alvar Agustí et al.   PLoS One

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis

(2011) Max A. Seibold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activation of the WNT/β-Catenin Pathway Attenuates Experimental Emphysema

(2010) Nikolaus Kneidinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

(2010) J. R. Rock et al.   Disease Models & Mechanisms

Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology

(2010) C. Vancheri et al.   EUROPEAN RESPIRATORY JOURNAL

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

(2009) Melanie Königshoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Studying Genetic Variations in Cancer Prognosis (and Risk): A Primer for Clinicians

(2009) S. Savas et al.   ONCOLOGIST

Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography

(2008) Harvey O. Coxson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One